Abstract Background Cutaneous leishmaniasis (CL) is endemic in Israel, and the past, has been attributed almost exclusively to Leishmania major . Over last decade or so, an increase tropica ( L. ) infections occurred several regions of Israel. Topical treatment Old World CL usually rule, however, some cases systemic indicated. Liposomal amphotericin B (L‐AmB) efficacious safe for treating visceral but its role various forms yet be defined. In this study, we summarize efficacy safety L‐AmB a...

Abstract Aims CF101 demonstrated a marked anti‐inflammatory effect in Phase 2 studies conducted patients with rheumatoid arthritis and dry eye syndrome. The aim of this study was to evaluate the safety efficacy for treatment moderate severe plaque‐type psoriasis. Materials methods This phase 2, multicentre, randomized, double‐blind, dose‐ranging, placebo‐controlled study. Seventy five psoriasis were enrolled, randomized treated (1, or 4 mg) placebo administered orally twice daily 12 weeks....

Phototherapy has a time-honoured place in the treatment of variety skin diseases adults. The use this modality children is limited mainly due to concerns about long-term carcinogenic potential. Only few clinical trials have been performed on efficacy and safety phototherapy children.To determine NB-UVB with atopic dermatitis (AD) psoriasis.This retrospective review outcomes 129 psoriasis AD, who were treated between 1998 2006 at our institute.Fifty per cent psoriatic patients 25% AD achieved...

Pemphigus vulgaris is a chronic autoimmune blistering disease with significant morbidity. Rituximab, approved as its first-line treatment, effectively induces remission. However, few studies have analysed the prognostic factors for improved rituximab outcomes. Therefore, this study aimed to identify such in cohort of pemphigus patients. A total 142 patients treated at Sheba Medical Center, data encompassing demographics, comorbidities, characteristics, and treatment outcomes, were...

Background. Excessive risk of cutaneous melanoma as a second cancer has been associated with benign or malignant tumors the nervous system. Cutaneous and system may independently aggregate in families. There are, however, no previous reports increased likelihood families patients or–of nero Methods. The occurrence cancers was examined series 904 and/or their family members. Results. Fifteen 17 members from this had one more additional relatives system, including astrocytoma, medulloblastoma,...

Chlorophyll (Chl) and bacteriochlorophyll (Bchl) have been made water soluble by transesterification with serine (Ser) at the propionyl residue tested as potential reagents for photodynamic therapy (PDT). Photocytotoxicity of conjugates Chl-Ser Bchl-Ser in M2R mouse melanoma was cell cultures. Tissue uptake clearance photosensitizers CD1 nude C57B1 mice implanted tumors are described. cultures determined microscopically [3H]thymidine incorporation. The LD50 values vitro were 0.05-0.1 microM...

Several systemic and regional risk factors have been described for erysipelas. However, those predisposing recurrent episodes are not well defined.We performed a retrospective analysis of 574 patients hospitalized in our institution during 3 year period. The included demographic, epidemiologic, medical chart review data with special attention to background disorders. single erysipelas were compared.The cases occurred mainly the lower limb several that statistically more common than episode...

To characterize the relationship between occupational sun exposure and seasonal variations in serum 25-OH-D3, four consecutive measurements of one per season, were taken 122 outdoor 104 indoor Israeli workers. Continuous UVB measurements, Beer Sheva, Israel, provided average daily standard erythema dose (SED) ambient solar UVB. The workers to was 4.4+/-1.6 h (4.0-37.6 SED) 0.9+/-0.5 (0.6-8.2 SED), respectively. At each season mean 25-OH-D3 significantly higher among than Mean increased from...

Abstract Background Cutaneous leishmaniasis ( CL ) due to Leishmania major L. is common in the Middle East; however, this skin infection may be under‐diagnosed when it presents atypically. Objective To highlight occurrence of uncommon presentations that elude diagnosis. Materials and methods A retrospective study was performed among patients who presented at The Sheba Medical Center between 2005 2014 with atypical clinical . Results Twelve unusual were identified. All infections acquired –...

Data regarding the risk for severe COVID19 in patients with autoimmune or inflammatory diseases are scarce. To estimate of those to develop a more infection All active and dermatologic and/or rheumatologic autoimmune/inflammatory were identified single tertiary center. The charts tested positive between 1 March 2020 31 May reviewed including demographics, co-morbidities, medications. outcome compared infected matched controls without an background. Overall, 974 381 268 COVID19, 35 out 13 225...

Abstract Background Narrowband ultraviolet B (NB‐UVB) phototherapy is a popular and relatively contemporary treatment option. However, only few studies to date have explored the potential risk of skin cancer following NB‐UVB treatment. Objective This study aimed investigate long‐term in patients treated with NB‐UVB. Methods cohort included psoriasis, vitiligo, mycosis fungoides at two university hospitals Israel 2000–2005. Patients were followed up for least 10 years. Data extracted from...

Abstract Background Pityriasis lichenoides comprises a clinical and pathological spectrum of disorders. So far no highly effective treatment has been reported. Previous small studies have suggested that ultraviolet B (UVB) is good alternative. Methods This retrospective analysis 29 pityriasis patients treated in our institution with broad‐ or narrow‐band UVB during the period 1996–2002. Twenty‐one these had one more previous unsuccessful treatments. Results Complete response was achieved...

Summary Background Localized scleroderma ( LS ) comprises a spectrum of sclerotic autoimmune diseases primarily affecting the dermis. Various treatment modalities have been recommended for management , but only few studies exist regarding efficacy bath PUVA photochemotherapy in . Objectives To evaluate retrospective study. Methods Twenty‐eight patients (23 women and five men) with diagnosis confirmed by histology, were included Patients treated thrice‐weekly regimen immersion 0.2 mg/1 water...

Background: Plaque-type palmoplantar psoriasis (PPTP) is a chronic recalcitrant dermatosis with treatment modalities ranging through topical, phototherapy or systemic. Phototherapy options include various forms of ultraviolet B (UVB) and A prior psoralen sensitization (PUVA). Currently, few comparative studies have been reported. Purpose: To compare Broad-Band UVB (BB-UVB) versus paint PUVA (p-PUVA) in regard to efficacy safety the PPTP. Methods: retrospective non-randomized cohort study...

Onchocerciasis is an infectious disease caused by the filaria Onchocerca volvulus. Very little known regarding onchocerciasis imported from endemic to nonendemic areas.To evaluate pruritic dermatitis simulating atopic in Ethiopian immigrants Israel.A retrospective study of 27 Israel was conducted. Demographics and clinical laboratory data were collected.Of group patients, 10 (37%) men 17 (63%) women. The average age at referral 29 years. All patients emigrated Kuwara, Ethiopia. Diagnosis...

Pemphigus vulgaris (PV) follows a chronic relapsing course where the mainstay of therapy has been oral corticosteroids and second-line immunosuppressive immunomodulating therapies. Successful responses have reported with rituximab, chimeric monoclonal anti-CD20 antibody targeting B lymphocytes, although its use in recalcitrant pemphigus is still being studied.A retrospective analysis presented 18 patients cutaneous mucous membrane involvement after disease relapse following steroid other...

The role of host and environmental factors in the pathogenesis multiple melanocytic nevi, atypical freckles was studied 1989 a random sample 3,040 Israeli males aged 17 years. Multiple nevi were significantly associated with family history melanoma or (odds ratio (OR) = 15.0), fair lightly pigmented skin color (OR 2.7 2.3, respectively), affiliation to high heterogenous risk group, determined by incidence rates Jewish migrants from corresponding origin 3.1 2.1, respectively). An...

AbstractBACKGROUND: The accepted regimen for terbinafine, one of the most effective treatments dermatophyte onychomycosis, is continuous administration 250 mg/day over 16 weeks. A few small studies, however, have raised possibility an alternative regimen: pulsed 500 1 week, every 4 weeks (over weeks), without decreasing treatment efficacy.OBJECTIVE: Our aim was to compare efficacy and safety both regimens in a large group patients.METHODS: Retrospective analysis 260 patients with culture...