A5012352347- Multiple Sclerosis Research Studies
- Heart Rate Variability and Autonomic Control
- Thermoregulation and physiological responses
- Climate Change and Health Impacts
- SARS-CoV-2 and COVID-19 Research
- Blood Pressure and Hypertension Studies
- Air Quality and Health Impacts
- Noise Effects and Management
- Health and Lifestyle Studies
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Heart rate and cardiovascular health
- Nutritional Studies and Diet
- Workplace Health and Well-being
- Vitamin D Research Studies
- Obesity, Physical Activity, Diet
- Bone health and osteoporosis research
- Meta-analysis and systematic reviews
- Long-Term Effects of COVID-19
- Dietary Effects on Health
- Blood transfusion and management
- Physical Activity and Health
- Non-Invasive Vital Sign Monitoring
- Advanced Database Systems and Queries
University of Haifa
2015-2025
Sheba Medical Center
1998-2023
Hebrew University of Jerusalem
2023
Tel Aviv University
2010-2022
Epistar (Taiwan)
2017
Israel Ministry of Health
2000
Loewenstein Hospital Rehabilitation Center
1992-1999
National Institute of Occupational Health
1993
The National Multiple Sclerosis Society and other expert organizations recommended that all patients with multiple sclerosis (MS) should be vaccinated against COVID-19. However, the effect of disease-modifying therapies (DMTs) on efficacy to mount an appropriate immune response is unknown. We aimed characterize humoral immunity in mRNA-COVID-19 MS vaccinees treated high-efficacy DMTs.We measured SARS-CoV-2 IgG using anti-spike protein-based serology (EUROIMMUN) 125 BNT162b2-COVID-19 vaccine...
// Talia Golan 1 , Elina Zorde Khvalevsky 2 Ayala Hubert 3 Rachel Malka Gabai Naama Hen Amiel Segal 4 Abraham Domb 5 Gil Harari 6 Eliel Ben David 7 Stephen Raskin Yuri Goldes Eran Goldin 8 Rami Eliakim Maor Lahav Yael Kopleman 9 Alain Dancour Amotz Shemi and Eithan Galun 10 The Sackler School of Medicine, Chaim Sheba Medical Center, Tel Aviv University, Aviv, Israel Silenseed Ltd., Jerusalem, Sharett Institute Oncology, Hadassah-Hebrew University Gastroenterology Institute, Shaare Zedek...
Objective Familial Mediterranean fever (FMF) is refractory to colchicine prophylaxis in 10–20% of patients. In a number patient series, treatment with anakinra, an interleukin‐1–blocking agent, prevented FMF attacks those colchicine‐resistant FMF. This study was undertaken evaluate the efficacy and safety anakinra FMF, using randomized controlled trial. Methods Patients receiving (dosage ≥1.5 ≤3 mg/day) were recruited randomly assigned receive or placebo (vehicle). The duration 4 months....
Appropriate immune response following COVID-19 vaccination is important in the context of disease-modifying treatments (DMTs). In a prospective cross-sectional study, we determined SARS-COV-2 IgG up to 6 months PfizerBNT162b2 414 multiple sclerosis (MS) patients and 89 healthy subjects. Protective was demonstrated untreated MS (N = 76, 100%), treated with Cladribine 48, Dimethyl fumarate 35, Natalizumab 32, Teriflunomide 39, similarly subjects 89, 97.8%). Response decreased Fingolimod 42,...
Leisure-time physical activity (LTPA) is a well-established protective factor for all-cause mortality and cardiovascular while occupational (OPA) has shown contradictory results. We examined the association between OPA coronary heart disease (CHD) mortality, tested its combined effect with LTPA.The CORDIS Study (Cardiovascular Occupational Risk Factor Determination in Israel Study) prospective cohort study of industrial workers during 1985-1989 followed-up 22 years. Data on self-reported...
Chronological age prediction from DNA methylation sheds light on human aging, health, and lifespan. Current clocks are mostly based linear models rely upon hundreds of sites across the genome. Here, we present GP-age, an epigenetic non-linear cohort-based clock for blood, 11,910 methylomes. Using 30 CpG alone, GP-age outperforms state-of-the-art models, with a median accuracy ∼2 years held-out blood samples, both array sequencing-based data. We show that aging-related changes occur at...
Measuring brain volume changes over time is an objective and dependable surrogate marker for the pathological processes that damage in relapsing-remitting multiple sclerosis (RRMS). These measures are particularly valuable monitoring long-term impact of immunomodulatory treatments such as cladribine. To evaluate oral cladribine treatment on loss patients with RRMS. This real-world study processed magnetic resonance imaging (MRI) scans using FreeSurfer's recon-all-clinical pipeline leveraging...
Information about metabolic comorbidities in patients with multiple sclerosis (MS) is scarce. Our aim was to examine the prevalence of syndrome (MetS) and its components long duration MS significant disability.Demographic clinical data, weight, height, waist circumference, blood pressure, levels fasting glucose, triglycerides high density lipoprotein cholesterol (HDL-C) were obtained from 130 Extended Disability Status Scale (EDSS) score ≥3.0.Seventy-two percent female, mean ± SD age 55.8...
Multiple sclerosis (MS) itself and first-line disease modifying therapies do not increase the risk of contracting COVID-19. However, home isolation is likely to result in a significant decrease participation leisure time physical activities an sedentary behavior. Therefore, using online cross-sectional survey we examined impact COVID-19 epidemic on activity (PA) behavior fitness level Israeli cohort people with multiple (PwMS). The PA questionnaire included 10 questions. Specifically,...
Corpus callosum (CC) is frequently involved in multiple sclerosis (MS). We aimed to investigate the relations between CC microstructure integrity as measured by diffusion tensor imaging (DTI) relapsing-remitting MS patients with low neurological disability comparison age-matched healthy subjects and further identify correlations DTI-CC parameters clinical variables of disease activity.CC volume was on 3.0T brain MRI Analyze software. DTI metrics acquired along 31 independent directions were...
Anabolic treatment is indicated for high and very-high risk patients with osteoporosis, but acceptance limited because current anabolic medications require subcutaneous injections. The purpose of this study was to assess the effects a novel orally administered PTH tablet on serum markers bone formation (PINP osteocalcin), resorption (crosslinked C-telopeptide [CTX]), BMD, safety in postmenopausal women low BMD or osteoporosis. In 6-mo, double-blind, placebo-controlled study, 161 were...
To examine possible seasonal changes in heart rate variability (HRV). Greater than normal mortality from cardiovascular disease (CVD) the winter has been reported for many countries and might be partly explained by considering CVD risk factors. Depression of HRV is an independent predictor arrhythmic complications cardiac death, it also among variables that may affected season year. We compared pairs 24 h data 120 healthy men who were examined once summer winter. Multivariate analyses...
The objective of this study was to evaluate the association physical activity at work with risk all-cause cardiovascular disease and cancer mortality. cohort consisted 3488 male, Israeli, industrial employees who participated in an 8-year follow-up study. During period 129 deaths were recorded: 54 from disease, 47 cancer, 28 other causes. Physical assessed entry on a 4-point scale (none, light, medium, high). Potential confounding demographic, anthropometric, socioeconomic variables, health...
Summary. Seasonal changes in blood count (haematocrit and haemoglobin values) have been described studies of small samples. Since Israel is characterized by high summer temperatures, we attempted to determine whether there are circannual count, how they influenced mean monthly temperature. In a cross‐sectional study, venous was drawn from 4317 male employees industry aged 20–64 years. Blood values were analysed month. To estimate possible serum osmolality. electrolytes also examined. Values...
Abstract The effects of industrial noise on resting heart rate and blood pressure were studied in 3 105 blue-collar workers. Heart measured different workers at various times during the workday. After controlling for several possible confounders, we found that females was associated positively with intensity (p = .036) time day .054). In males, intensity; however, such association related to .046). No associations either sex. We plotted mean by exposed high [≥ 80 db(A)] low noise, no...
Studies on the effects of long-term exposure to industrial noise resting blood pressure have yielded inconsistent results. Ambulatory and heart rate were monitored simultaneously with in normotensive male workers Israel (85 aged 25 44 77 45 65 years). In younger group, average ambulatory systolic was 3.2 mm Hg higher diastolic 2.3 subjects exposed more than 85 dBa (P < .001), after adjusting for potential confounding variables. those 65, 3.3 lower unchanged noise-exposed subjects. 2.7 2.6...
Bioavailability of calcium is an important consideration when designing supplements for achieving adequate intake, mainly in high-risk, and aged populations. Alternative supplementation strategies may be able to circumvent absorption issues commonly seen with supplements. The objective this study was assess the bioavailability a single serving two formulations vs. comparator product healthy postmenopausal women.A total 24 participants between 45 65 years were enrolled randomized,...