A5025785826- Multiple Sclerosis Research Studies
- SARS-CoV-2 and COVID-19 Research
- Peripheral Neuropathies and Disorders
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Polyomavirus and related diseases
- Optical Imaging and Spectroscopy Techniques
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Balance, Gait, and Falls Prevention
- Effects of Vibration on Health
- Genomics, phytochemicals, and oxidative stress
- Williams Syndrome Research
- Muscle activation and electromyography studies
- Cerebral Palsy and Movement Disorders
- Reproductive System and Pregnancy
- Hops Chemistry and Applications
- Effects of Radiation Exposure
- Systemic Sclerosis and Related Diseases
- Mycobacterium research and diagnosis
- Gut microbiota and health
- Dermatological and Skeletal Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- IL-33, ST2, and ILC Pathways
- Heart Rate Variability and Autonomic Control
Sheba Medical Center
2021-2024
Tel Aviv University
2021-2024
The National Multiple Sclerosis Society and other expert organizations recommended that all patients with multiple sclerosis (MS) should be vaccinated against COVID-19. However, the effect of disease-modifying therapies (DMTs) on efficacy to mount an appropriate immune response is unknown. We aimed characterize humoral immunity in mRNA-COVID-19 MS vaccinees treated high-efficacy DMTs.We measured SARS-CoV-2 IgG using anti-spike protein-based serology (EUROIMMUN) 125 BNT162b2-COVID-19 vaccine...
Background: Since vaccination against coronavirus disease 2019 (COVID-19) became available, risks related to vaccinating patients with multiple sclerosis (MS) need be carefully assessed. Objective: Characterize safety and occurrence of immediate relapses following COVID-19 in a large cohort MS patients. Methods: We assessed the BNT162b2 adult Results: Between 20 December 2020 25 January 2021, 555 received first dose vaccine 435 second dose. There were three cases infection encountered after...
Appropriate immune response following COVID-19 vaccination is important in the context of disease-modifying treatments (DMTs). In a prospective cross-sectional study, we determined SARS-COV-2 IgG up to 6 months PfizerBNT162b2 414 multiple sclerosis (MS) patients and 89 healthy subjects. Protective was demonstrated untreated MS (N = 76, 100%), treated with Cladribine 48, Dimethyl fumarate 35, Natalizumab 32, Teriflunomide 39, similarly subjects 89, 97.8%). Response decreased Fingolimod 42,...
Multiple sclerosis (MS) is an immune-mediated disease whose precise etiology unknown. Several studies found alterations in the microbiome of individuals with MS, but mechanism by which it may affect MS poorly understood. Here we analyze 129 and find that they harbor distinct microbial patterns compared controls. To study functional consequences these differences, measure levels 1,251 serum metabolites a subgroup subjects unravel metabolite signature separates affected from controls nearly...
Background: Optical coherence tomography (OCT) is a sensitive method for quantifying retinal neuronal and axonal structures. Reductions in nerve fiber layer (RNFL) ganglion cell inner plexiform (GCIPL) thicknesses have reported association with white grey matter atrophy multiple sclerosis (MS). We hypothesized that the thinning of intraretinal measurements associates cognitive decline MS patients no prior event optic neuritis (ON). Methods: OCT NeuroTrax computerized assessments were...
Abstract Background Prevention of cognitive decline in Multiple Sclerosis (MS) is major importance. We explored the effect a 6 months computerized game training program on performance MS patients with mild impairment. Methods This was single-center, randomized prospective study. enrolled this study 100 eligible treated Interferon-beta-1a (Rebif). All had impairment either executive function or information processing speed. Patients were 1:1 to use games platform by HappyNeuron (HN) receive...
Longitudinal data are vital in order to understand intra individual gait changes with the progression of multiple sclerosis (MS). Therefore, primary aim this study was explore relationship between disability major spatio-temporal parameters people MS (PwMS). PwMS (n = 83) completed two assessments performed at separate time points (M1, M2). For each individual, absolute difference Expanded Disability Status Scale (EDSS) score, key gait, Falls Efficacy International (FES-I), and 12-item...
Abstract Multiple Sclerosis (MS) has been linked to a variety of environmental risk factors, including smoking, Epstein-Barr Virus infection, and childhood obesity. There is some evidence support relationship between alcohol consumption MS risk, but this finding inconsistent across cohorts. A protective link seen in Swedish Danish cohorts, however from other cohorts mendelian randomisation studies have failed relationship. We assessed the (never vs. ever drinking) 409,228 individuals (2100...
Relapsing-remitting multiple sclerosis (RRMS) affects predominantly young women within reproductive years. As an increased risk of relapses is known to occur during the post-partum period, it important consider treatment options.Evaluate effects intravenous immunoglobulins (IVIg) prevent relapses.We prospectively followed 198 pregnant female RRMS patients, 67 treated with IVIg pregnancy and three months post-partum, 131 untreated patients that served as controls.During pre-gestation year,...
Hemodynamics in the prefrontal cortex (PFC) while walking forward and backward, with without an additional cognitive task (motor single-task [ST] motor dual-task [DT]) have not been studied people multiple sclerosis (pwMS).To investigate PFC hemodynamics during as well backward walking, a task, pwMS healthy controls.Observational case-control study.Sheba Multiple Sclerosis Center, Tel-Hashomer, Israel.Eighteen (36.1±11.7 years, 66.6% female) 17 controls (37.5±13.8 76.5% female).Each subject...
Background: Worldwide spread of COVID-19 disease highlights the need for assessment long-term humoral immunity in convalescent subjects.Objectives: Evaluate IgG SARS-CoV-2 antibody response and B-cell memory over-time subjects.Methods: Blood samples were collected from a cohort subjects recovering healthy that donated blood. antibodies quantitatively detected by ELISA using anti-S1 spike IgG. spike-specific B-cells evaluated randomly selected group reversed FluroSpot based on human...
Background Investigating brain activation during motor imagery (MI) tasks in people with multiple sclerosis (pwMS) can increase the knowledge of neural mechanisms underlying dysfunction MS and, hopefully, aid developing improved rehabilitation strategies. Objective To investigate supplementary area and premotor cortex via functional near-infrared spectroscopy (fNIRS) a hand manipulation task, comparing MI actual practice (AP) pwMS. Methods Each subject completed sequence 4 consecutive manual...
MRI activity is less frequent among secondary progressive multiple sclerosis (SPMS) patients. In the current study, we aimed to identify SPMS patients with higher radiological disease (RDA) and determine their clinical characteristics.We evaluated occurrence of RDA in followed at Sheba Multiple Sclerosis Center between January 1, 2015, December 31, 2020. All underwent brain spinal cord examinations as a routine follow-up unrelated activity. Patients were subdivided into non-RDA groups based...
The motoric cognitive risk (MCR) syndrome, defined as the coexistence of slow gait and subjective complaints, has yet not been researched in people with multiple sclerosis (pwMS).To examine prevalence MCR syndrome pwMS its association disability, disease duration, perceived fatigue, fear falling.The study comprised 618 [43.7 (SD = 12.6) years, 61.7% females]. Gait speed was measured by GAITRite™ electronic walkway (CIR Systems, Inc. Haverton, PA, USA). Cognitive status according to global...