A5063456699- Cancer Research and Treatments
- 3D Printing in Biomedical Research
- Porphyrin and Phthalocyanine Chemistry
- Metal-Catalyzed Oxygenation Mechanisms
- Glioma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Autophagy in Disease and Therapy
- Nanoparticle-Based Drug Delivery
- Antioxidant Activity and Oxidative Stress
- Metal complexes synthesis and properties
- Free Radicals and Antioxidants
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Occupational and environmental lung diseases
- Salmonella and Campylobacter epidemiology
- Ovarian cancer diagnosis and treatment
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Listeria monocytogenes in Food Safety
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Cancer Cells and Metastasis
Novocure (United States)
2021-2024
Technion – Israel Institute of Technology
2007-2022
Novocure (Jersey)
2022
Rappaport Family Institute for Research in the Medical Sciences
2017-2022
Pluristem Therapeutics (Israel)
2021
Abstract Purpose Tumor Treating Fields (TTFields) are electric fields that disrupt cellular processes critical for cancer cell viability and tumor progression, ultimately leading to death. TTFields therapy is approved treatment of newly-diagnosed glioblastoma (GBM) concurrent with maintenance temozolomide (TMZ). Recently, the benefit TMZ in combination lomustine (CCNU) was demonstrated patients O 6 -methylguanine DNA methyltransferase (MGMT) promoter methylation. The addition adjuvant plus...
Antioxidants that work! The iron corrole 1-Fe (see picture) is a potent catalyst for decomposition of reactive oxygen and nitrogen species binds selectively to lipoproteins. complex also affects cholesterol levels its cellular efflux. more effective than natural antioxidants in reducing atherosclerosis development mice. LDL=low-density lipoprotein. Supporting information this article available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z801149_s.pdf or from author. Please...
The high environmental adaptability of bacteria is contingent upon their ability to sense changes in surroundings. Bacterial pathogen entry into host poses an abrupt and dramatic change, during which successful pathogens gauge multiple parameters that signal localization. facultative human Listeria monocytogenes flourishes soil, water food, ~50 different animals, serves as a model for intracellular infection. L. identifies by sensing both physical (e.g., temperature) chemical metabolite...
ObjectivesTumor Treating Fields (TTFields) are low intensity, intermediate frequency, alternating electric fields with antimitotic effects on cancerous cells. TTFields concomitant pemetrexed and a platinum agent approved in the US EU as first line therapy for unresectable, locally advanced or metastatic malignant pleural mesothelioma (MPM). The goal of current study was to characterize mechanism action MPM cell lines animal models.MethodsHuman MSTO-211H NCI-H2052 were treated determine...
Tumor Treating Fields (TTFields) are electric fields that exert physical forces to disrupt cellular processes critical for cancer cell viability and tumor progression. TTFields induce anti-mitotic effects through the disruption of mitotic spindle abnormal chromosome segregation, which trigger several forms death, including immunogenic death (ICD). The efficacy concomitant with anti-programmed death-1 (anti-PD-1) treatment was previously shown in vivo is currently under clinical...
753 Background: Pancreatic cancer remains one of the most aggressive malignancies, frequently diagnosed at locally advanced or metastatic stage. In setting, first-line chemotherapy options include gemcitabine with nab-paclitaxel FOLFIRINOX, a combination regimen fluorouracil, oxaliplatin, irinotecan and leucovorin. The FOLFIRINOX is however associated greater toxicity hence used only in patients good performance status. BRCA-mutated tumors seem to be more sensitive due DNA-damaging,...
Abstract Tumor Treating Fields (TTFields) are electric fields that induce cancer cell death. Genomic analysis of glioblastoma tumors resected from TTFields-treated patients suggested a potential link between reduced or absent response to TTFields and activating mutations in the phosphatidylinositol 3-kinase (PI3K) p110α subunit (PIK3CA). Our study aimed investigate role PI3K/AKT pathway TTFields. We tested changes signaling pathways control versus U-87 MG glioblastoma, A2780 ovarian...
Functionally defective HDL emerges as a main risk factor in cardiovascular diseases, on top of imbalanced serum lipoprotein ratios. We now show that 1-Fe, an iron(III) corrole catalytic antioxidant, spontaneously forms tightly-bound conjugates with LDL (secondarily) and (primarily) human serum. This is demonstrated by HPLC separation serum/1-Fe mixtures analysis the corrole-containing fractions UV-vis circular dichroism spectroscopy. The LDL/1-Fe HDL/1-Fe are resistant to functionality...
Hepatocellular carcinoma (HCC), a highly aggressive liver cancer, is leading cause of cancer-related death. Tumor Treating Fields (TTFields) are electric fields that exert antimitotic effects on cancerous cells. The aims the current research were to test efficacy TTFields in HCC, explore underlying mechanisms, and investigate possible combination with sorafenib, one few front-line treatments for patients advanced HCC. HepG2 Huh-7D12 human HCC cell lines treated at various frequencies...
Tumor Treating Fields (TTFields) therapy is a non-invasive, loco-regional, anti-mitotic treatment modality that targets rapidly dividing cancerous cells, utilizing low intensity, alternating electric fields at cancer-cell-type specific frequencies. TTFields approved for the of newly diagnosed and recurrent glioblastoma (GBM) in US, Europe, Israel, Japan, China. The favorable safety profile patients with GBM partially attributed to rate mitotic events normal, quiescent brain cells. However,...
Bioavailability of calcium is an important consideration when designing supplements for achieving adequate intake, mainly in high-risk, and aged populations. Alternative supplementation strategies may be able to circumvent absorption issues commonly seen with supplements. The objective this study was assess the bioavailability a single serving two formulations vs. comparator product healthy postmenopausal women.A total 24 participants between 45 65 years were enrolled randomized,...
Abstract Background: Tumor Treating Fields (TTFields) are electric fields that disrupt cellular processes critical for cancer cell viability and tumor progression. While the mechanism of action TTFields has been associated with an antimitotic effect impaired DNA damage repair mechanisms, application also shown to increase membrane permeability glioblastoma cells. The current study examined whether increased is relevant in other types may be leveraged facilitate uptake anticancer agent...
Listeria monocytogenes is a saprophyte and human intracellular pathogen. Upon invasion into mammalian cells, it senses multiple metabolic environmental signals that collectively trigger its transition to the pathogenic state. One of these tripeptide glutathione, which acts as an allosteric activator L. monocytogenes's master virulence regulator, PrfA. While glutathione synthesis by was shown be critical for PrfA activation gene expression, remains unclear how this synthesized in changing...
Determination of the cellular uptake macrocyclic iron(III) complexes by a facile method, accompanied cell viability tests under both basal and induced oxidative stress, demonstrates that protection against intracellular stress requires reasonably high internalization favorable anti/prooxidant profiles. Of four tested complexes, only amphipolar corrole met these criteria.
Background Ovarian cancer is the leading cause of mortality among gynecological malignancies. Carboplatin and poly (ADP-ribose) polymerase inhibitors (PARPi) are often implemented in treatment ovarian cancer. Homologous recombination deficient (HRD) tumors demonstrate increased sensitivity to these treatments; however, many patients homologous proficient (HRP). TTFields non-invasive electric fields that induce an HRD-like phenotype various types. The current study aimed investigate impact...
The corrole-based catalytic antioxidant 1-Fe reduced the cholesterol biosynthesis ability of macrophages, harvested from mice treated with it. and a non-redox active analogue it affect committed step biosynthetic pathway – HMG-CoA reductase catalysed reaction by acting as allosteric inhibitors this key enzyme.
Wirkungsvoller als die Natur: Das Eisencorrol 1-Fe (siehe Bild) ist ein potenter Katalysator für Zersetzung von reaktiven Sauerstoff- und Stickstoffspezies, selektiv an Lipoproteine binden. Der Komplex beeinflusst auch den Cholesterinspiegel zellulären Cholesterin-Efflux. vermindert Atheroskleroseentwicklung in Mäusen wirkungsvoller natürliche Antioxidantien. LDL=Lipoprotein niedriger Dichte.
Abstract Introduction: Though largely preventable, cervical cancer remains a significant health issue. Treatment of early-stage disease usually involves surgery; while systemic therapy is often required for advanced, recurrent, or metastatic cases. Most patients with advanced receive cisplatin-containing chemotherapy combinations in the first-line setting. TTFields are electric fields that disrupt cellular processes critical cell viability and tumor progression. Concomitant treatment...
Abstract Purpose/Objectives: Pancreatic cancer remains a leading cause of cancer-related death, with limited treatment options available for the advanced stage. PARP inhibitors (PARPi) are effective in patients germline BRCA mutations. Recently, TTFields – electric fields that disrupt cellular processes critical cell viability have been shown to induce state BRCAness various types. The objective this study was examine possible sensitization wild type pancreatic lines inhibition by...