A5064957809- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Natural Compounds in Disease Treatment
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Caveolin-1 and cellular processes
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Monoclonal and Polyclonal Antibodies Research
- Advanced Antenna and Metasurface Technologies
University of Minnesota Medical Center
2017-2025
University of Minnesota
2015-2022
Nanjing University of Science and Technology
2022
National University of Defense Technology
2020
Wuhan University
2012-2019
Wuhan Donghu University
2019
University of Minnesota System
2019
Zhongnan Hospital of Wuhan University
2016-2018
Sun Yat-sen University
2011
Sun Yat-sen University Cancer Center
2011
Abstract Resident fibroblasts that contact tumor epithelial cells (TEC) can become irreversibly activated as cancer-associated-fibroblasts (CAF) stimulate oncogenic signaling in TEC. In this study, we evaluated the cross-talk between CAF and TEC isolated from tumors generated a mouse model of KRAS/mut p53-induced pancreatic cancer (KPC mice). Transcriptomic profiling conducted after treatment with anticancer compound Minnelide revealed deregulation TGFβ pathway CAF, resulting an apparent...
Pancreatic cancer stromal microenvironment is considered to be the major reason for failure of conventional and targeted therapy this disease. The desmoplastic stroma, comprising mainly collagen glycosaminoglycans like hyaluronan (HA), responsible compression vasculature in tumor resulting impaired drug delivery poor prognosis. Minnelide, a water-soluble prodrug triptolide currently phase I clinical trial, has been very effective multiple animal models pancreatic cancer. However, whether...
Existing preclinical models of human colorectal cancer (CRC) that rely on syngeneic subcutaneous grafts are problematic, because increasing evidence the immune microenvironment in tissue is significantly different from gastrointestinal tract. Similarly, existing orthotopic use a laparotomy for establishing also surgical procedure results extensive inflammation, thereby creating nonphysiologic tumor microenvironment. To facilitate bench-to-bedside translation CRC immunotherapy strategies, we...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common cancer death reasons. Anti-tumor necrosis factor-alpha (TNF-α) antibodies have shown promising effects in PDAC pre-clinical models. However, prognostic values TNF-α, underlying mechanisms by which anti-TNF-α treatments inhibit PDAC, and potential synergistic with chemotherapy are still unclear.To identify targeting TNF-α we measured expression different stages initiation evaluated its significance a pancreatic cohort. We found...
Altered expression of epithelial or stromal caveolin-1 (Cav-1) is observed in various types human cancers. However, the clinical significance Cav-1 gastric cancer (GC) remains largely unknown. The present study aims to explore clinicopathological and prognostic value both tumor cells associated fibroblasts (CAFs) GC.Quantum dots immunofluorescence histochemistry was performed examine 20 cases gastritis without intestinal metaplasia (IM), with IM 286 GC. Positive rates IM, GC showed a...
Colorectal cancer (CRC) currently ranks as the third most common in United States, and its incidence is on rise, especially among younger individuals. Despite remarkable success of immune checkpoint inhibitors (ICIs) various cancers, CRC patients fail to respond due intrinsic resistance mechanisms. While microsatellite instability-high phenotypes serve a reliable positive predictive biomarker for ICI treatment, majority with microsatellite-stable (MSS) tumors remain ineligible this...
// Rachel Isaksson Vogel 1, * , Tanya Pulver Wiebke Heilmann 2, Ashley Mooneyham 1 Sally Mullany Xianda Zhao 3 Maryam Shahi 4 James Richter Molly Klein Liqiang Chen 5 Rui Ding Gottfried Konecny 6 Stefan Kommoss 2 Boris Winterhoff Rahel Ghebre Martina Bazzaro Masonic Cancer Center and Department of Obstetrics, Gynecology Women's Health, University Minnesota, Minneapolis, MN, USA Hospital Tuebingen University, Tuebingen, Germany Division Basic Translational Research, Surgery, Pathology...
Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication. Valid assays needed accurately assess the downstream effects TNT-mediated transfer cellular signals in vitro. We recently reported modified transwell assay system designed test therapeutic oncolytic virus, and viral-activated drugs, between cells via TNTs. The objective current study was...
Immunotherapies are used as adjuvant therapies for cancers. However, knowledge of how traditional cancer treatments affect immunotherapies is limited. Using mouse models, we demonstrate that tumor-draining lymph nodes (TdLNs) critical tumor antigen-specific T cell response. removing TdLNs concurrently with established primary tumors did not the immune checkpoint blockade (ICB) response on localized secondary due to immunotolerance in and distribution cells peripheral lymphatic organs....
Caveolin-1 (Cav-1) expression deficiency and autophagy in tumor stromal fibroblasts (hereafter fibroblasts) are involved proliferation progression, particularly breast prostate cancer. The aim of this study was to detect the fibroblastic Cav-1 LC3B, markers autophagy, gastric cancer (GC) analyze their clinical significances. Furthermore, because Epstein-Barr virus (EBV)-associated GC (EBVaGC) is a unique subtype GC; we compared differential LC3B EBVaGC non-EBVaGC. Quantum dots (QDs)-based...
Junctional adhesion molecules are important components of tight junctions, and Eph/ephrin proteins constitute the largest family receptor tyrosine kinases. Both junctional involved in normal tissue development cancer progression. However, expression levels clinical significances molecule-A, a member molecules, EphB2, family, lung adenocarcinoma patients unclear. Therefore, this study, we aimed to identify prognostic values molecule-A EphB2 patients' cohort. In our 70 (55.6%) showed high...
Infection by an oncogenic human papillomavirus (HPV), in particular HPV16 and 18, is a high risk factor for developing cervical cancer; however, viral infection alone not sufficient cancer progression. Autophagy hypothesized to be important process during carcinogenesis. The aim of the present study was investigate association between autophagy high-risk HPV (hrHPV) squamous cell carcinomas (SCCs), analyze clinical significance this association. Quantum dot (QD)-based immunofluorescence...
Colorectal cancer (CRC) is one of the most common malignancies in both morbidity and mortality. Immune checkpoint blockade (ICB) treatments have been successful a portion mismatch repair-deficient (dMMR) CRC patients but failed repair-proficient (pMMR) patients. Atypical Chemokine Receptor 4 (ACKR4) implicated regulating dendritic cell (DC) migration. However, roles ACKR4 development anti-tumor immunoregulation are not known. By analyzing human tissues, transgenic animals, genetically...