A5075665555- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Microtubule and mitosis dynamics
- Molecular Communication and Nanonetworks
- Carbon Nanotubes in Composites
- Nanoplatforms for cancer theranostics
- Planarian Biology and Electrostimulation
- Cellular Mechanics and Interactions
- Advanced biosensing and bioanalysis techniques
- Nanopore and Nanochannel Transport Studies
- Cardiac Health and Mental Health
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neural Engineering
- Chemical Reactions and Isotopes
- Protist diversity and phylogeny
- Radiation Therapy and Dosimetry
- Tissue Engineering and Regenerative Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Cell Image Analysis Techniques
- Microfluidic and Bio-sensing Technologies
- Advanced Electron Microscopy Techniques and Applications
- RNA Interference and Gene Delivery
- Cardiac Arrest and Resuscitation
University of Minnesota
2018-2025
Twin Cities Orthopedics
2019-2024
Abstract Intercellular communication plays a critical role in the ever-evolving landscape of invasive cancers. Recent studies have elucidated potential tunneling nanotubes (TNTs) this function. TNTs are long, filamentous, actin-based cell protrusions that mediate direct cell-to-cell between malignant cells. In study, we investigated formation response to variable concentrations chemotherapeutic drug doxorubicin, which is used extensively treatment cancer patients. Doxorubicin stimulated an...
Intercellular communication is vital to the ecosystem of cancer cell organization and invasion. Identification key cellular cargo their varied modes transport are important considerations in understanding basic mechanisms growth. Gap junctions, exosomes, apoptotic bodies play roles as physical modalities mediating intercellular transport. Tunneling nanotubes (TNTs)-narrow actin-based cytoplasmic extensions-are unique structures that facilitate direct, long distance cell-to-cell cargo,...
Disruption of intercellular communication within tumors is emerging as a novel potential strategy for cancer-directed therapy. Tumor-Treating Fields (TTFields) therapy treatment modality that has itself emerged over the past decade in active clinical use patients with glioblastoma and malignant mesothelioma, based on principle using low-intensity alternating electric fields to disrupt microtubules cancer cells undergoing mitosis. There need identify other cellular molecular effects this...
Abstract Tumor Treating Fields (TTFields) is a novel therapeutic strategy that uses alternating electric fields to disrupt mitosis in actively dividing cells through exertion of dielectrophoretic force and dipole alignment on microtubule subunits. However, the additional effects TTFields cellular morphology communication remain unclear. Tunneling nanotubes (TNTs) are ultrafine F-actin-based protrusions facilitate intercellular cell-cell contact, including efficient transport molecular cargo...
Abstract The purpose of this study was to evaluate the effects tumor-treating fields (TTFields) on tunneling nanotubes (TNTs) in malignant mesothelioma. TTFields have emerged as a therapeutic modality for treatment glioblastoma, through application alternating electric fields, which exert dipole alignment and dielectrophoretic force. force is intensified cellular compartments that are non-uniform size shape such mitotic furrow. TNTs filamentous actin protrusions conduits intercellular...
The purpose of this study was to evaluate the effects tumor-treating fields (TTFields) on tunneling nanotubes (TNTs) in malignant mesothelioma. TTFields have emerged as a therapeutic modality for treatment glioblastoma, through application alternating electric fields, which exert dipole alignment and dielectrophoretic force. force is intensified cellular compartments that are non-uniform size shape such mitotic furrow. TNTs filamentous actin protrusions conduits intercellular communication...
Abstract Intercellular communication is critical for the development of invasive cancers. Multiple forms intercellular have been well characterized, involving diffusible soluble factors or contact-dependent channels immediately adjacent cells. Over past 1-2 decades, emergence a unique form F-actin-based cellular protrusion known as tunneling nanotubes (TNTs) has filled niche long-range cell-contact dependent that facilitates cell growth, differentiation, and in case cancer phenotypes, more...