A5036352158- Listeria monocytogenes in Food Safety
- Salmonella and Campylobacter epidemiology
- Viral Infections and Vectors
- Sulfur Compounds in Biology
- interferon and immune responses
- Bat Biology and Ecology Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Mosquito-borne diseases and control
- Metabolism and Genetic Disorders
- Vibrio bacteria research studies
- Molecular Biology Techniques and Applications
- RNA regulation and disease
- RNA Research and Splicing
- Animal Genetics and Reproduction
- Aquaculture disease management and microbiota
- Salivary Gland Tumors Diagnosis and Treatment
- Microbial Inactivation Methods
- Aquaculture Nutrition and Growth
- Virus-based gene therapy research
- Immune responses and vaccinations
- Oral and Maxillofacial Pathology
- Head and Neck Cancer Studies
Tel Aviv University
2017-2025
The high environmental adaptability of bacteria is contingent upon their ability to sense changes in surroundings. Bacterial pathogen entry into host poses an abrupt and dramatic change, during which successful pathogens gauge multiple parameters that signal localization. facultative human Listeria monocytogenes flourishes soil, water food, ~50 different animals, serves as a model for intracellular infection. L. identifies by sensing both physical (e.g., temperature) chemical metabolite...
Abstract Bats have adapted to pathogens through diverse mechanisms, including increased resistance – rapid pathogen elimination, and tolerance limiting tissue damage following infection. In the Egyptian fruit bat (an important model in comparative immunology) several mechanisms conferring disease were discovered, but underpinning remain poorly understood. Previous studies on other species suggested that elevated basal expression of innate immune genes may lead Here, we test whether such...
Bats host a range of disease-causing viruses without displaying clinical symptoms. The mechanisms behind this are continuous source interest. Here, we studied the antiviral response in Egyptian fruit bat and Kuhl's pipistrelle, representing two subordinal clades. We profiled fibroblasts using RNA sequencing compared with primate rodent responses. Both bats upregulate similar genes; however, subset these genes is transcriptionally divergent between them. These also evolve rapidly sequence,...
Listeria monocytogenes is a saprophyte and human intracellular pathogen. Upon invasion into mammalian cells, it senses multiple metabolic environmental signals that collectively trigger its transition to the pathogenic state. One of these tripeptide glutathione, which acts as an allosteric activator L. monocytogenes's master virulence regulator, PrfA. While glutathione synthesis by was shown be critical for PrfA activation gene expression, remains unclear how this synthesized in changing...
Abstract The Egyptian fruit bat displays tolerance to lethal viruses and unique dietary adaptations, but the molecular basis for this is poorly understood. To end, we generated detailed maps of gut, lung blood cells using spatial single-cell transcriptomics. We compared with mouse human reveal divergence in genetic programs associated environmental interactions immune responses. Complement system genes are transcriptionally divergent, uniquely expressed gut epithelium, undergo rapid...
Abstract Background This study explores the unique characters of high dose radioactive iodine (RAI) induced chronic sialadenitis. Methods A retrospective patients having received salivary endoscopy and followed in our outpatient clinic. Results total 100 met inclusion criteria, 75 were diagnosed with idiopathic sialoadenitis 25 radio‐iodine (RIS). The main complaint both groups was swelling parotid gland. Pain, dysphagia, xerostomia observed considerably more RIS group. During...
Listeria monocytogenes is an environmental saprophyte and intracellular bacterial pathogen. Upon invading mammalian cells, the bacterium senses abrupt changes in its metabolic environment, which are rapidly transduced to regulation of virulence gene expression. To explore relationship between L. metabolism virulence, we monitored expression dynamics across a library genetic mutants grown under two conditions known activate virulent state: charcoal-treated rich medium containing...
Abstract Listeria monocytogenes ( Lm ) is a saprophyte and human intracellular pathogen. Upon invasion into mammalian cells, it senses multiple metabolic environmental signals that collectively trigger its transition to the pathogenic state. One of these tripeptide glutathione, which acts as an allosteric activator ’s master virulence regulator, PrfA. While glutathione synthesis by was shown be critical for PrfA activation gene expression, remains unclear how this synthesized under changing...