A5087249442- Microbial Inactivation Methods
- Microfluidic and Bio-sensing Technologies
- Advanced MRI Techniques and Applications
- Head and Neck Surgical Oncology
- Plasma Applications and Diagnostics
- Magnetic and Electromagnetic Effects
- Pancreatic and Hepatic Oncology Research
- Neonatal and fetal brain pathology
- Cancer Research and Treatments
- Infectious Diseases and Tuberculosis
- Advanced Radiotherapy Techniques
- Iron Metabolism and Disorders
- Meningioma and schwannoma management
- Advanced Neuroimaging Techniques and Applications
- Dermatological and Skeletal Disorders
- Metabolism and Genetic Disorders
- Ear Surgery and Otitis Media
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal Respiratory Health Research
- Cerebrospinal fluid and hydrocephalus
- Facial Nerve Paralysis Treatment and Research
- Medical Imaging Techniques and Applications
- Acute Ischemic Stroke Management
- Neurofibromatosis and Schwannoma Cases
- Parathyroid Disorders and Treatments
Shaare Zedek Medical Center
2006-2024
Hebrew University of Jerusalem
2015-2024
Hadassah Medical Center
2011-2018
Washington University Medical Center
2015
George Washington University
2015
George Washington University Hospital
2014
Ben-Gurion University of the Negev
2006
Magen David Adom
1981
// Talia Golan 1 , Elina Zorde Khvalevsky 2 Ayala Hubert 3 Rachel Malka Gabai Naama Hen Amiel Segal 4 Abraham Domb 5 Gil Harari 6 Eliel Ben David 7 Stephen Raskin Yuri Goldes Eran Goldin 8 Rami Eliakim Maor Lahav Yael Kopleman 9 Alain Dancour Amotz Shemi and Eithan Galun 10 The Sackler School of Medicine, Chaim Sheba Medical Center, Tel Aviv University, Aviv, Israel Silenseed Ltd., Jerusalem, Sharett Institute Oncology, Hadassah-Hebrew University Gastroenterology Institute, Shaare Zedek...
To determine whether high-dose irreversible electroporation (IRE) ablation induces thermal effects in normal liver tissue.Animal care and use committee approval was obtained prior to the experiments. IRE (n = 78) performed by a single four-person team vivo 22 porcine livers applying electric current two 1.3-cm-diameter circular flat-plate electrodes spaced 1 cm apart. Cardiac-gated pulses 40-360) were systematically applied at varying voltages (1500-2900 V). End temperatures zone center...
Purpose To study the effects of surrounding electrical microenvironment and local tissue parameters on outcome irreversible electroporation (IRE) ablation in porcine muscle, kidney, liver tissue. Materials Methods Animal Care Use Committee approval was obtained, National Institutes Health guidelines were followed. IRE (n = 90) applied muscle 44), kidney 28), 18) 18 pigs. Two electrodes with tip exposure 1.5–2 cm used at varying voltages (1500–3000 V), pulse repetitions 70–100), length...
To characterize ultrasonographic (US) findings after irreversible electroporation (IRE) to determine the utility of these in accurate assessment ablation margins.The institutional animal care and use committee approved study. IRE (n = 58) was performed vivo 16 pig livers by using two 18-gauge electrodes with 2-cm tip exposure, 1.5- or 2.0-cm interelectrode spacing, an generator. Energy deposition applied at 2250-3000 V (pulse length, 50-100 μsec; pulse repetition, 50-100). Ablations were...
The purpose of this study was to prospectively characterize and optimize irreversible electroporation ablation determine the best parameters achieve largest target zones coagulation for two electrodes.Ultrasound-guided (n=110) performed in vivo 25 pig livers using 18-gauge electrodes an generator. Five variables energy deposition electrode configuration were sequentially studied: number electrical pulses (n=20-90), length (20-100 microseconds), generator voltage (2250-3000 V), interelectrode...
To prospectively determine optimal parameters with which to achieve defined large target zones of coagulation by using irreversible electroporation (IRE) four-electrode arrays and the time needed this treatment effect in an vivo animal model.This study was approved care use committee. Ultrasonography (US)-guided IRE ablation (n = 90) performed 69 pig livers array four electrodes (18 gauge) generator. Cardiac-gated 100-µsec pulses were applied sequentially between six sets electrode pairs at...
Strict iron regulation is essential for normal brain function. The homeostasis, determined by the milieu of available compounds, impaired in aging, neurodegenerative diseases and cancer. However, non-invasive assessment different molecular environments implicating tissue's homeostasis remains a challenge. We present magnetic resonance imaging (MRI) technology sensitive to living (the r1-r2* relaxivity). In vitro, our MRI approach reveals distinct paramagnetic properties ferritin, transferrin...
Glioblastoma multiforme (GBM) remains an incurable condition, associated with a median survival time of about 15 months best standard care and 5-year rate <10%. We report on four GBM patients combination treatment regimens that included oncolytic virus (OV) immunotherapy, who achieved clinical radiological responses long-time thus far up to 14 years good quality life. discuss the findings provide new insights into this treatment, scientific rationale innovative promising therapy,...
4037 Background:K-Ras mutation G12D is most prevalent in pancreatic adenocarcinoma (PDAC). siRNA against the K-Ras (siG12D) mutant had showed significant preclinical anti-tumor effects. siG12D LODER - miniature biodegradable polymeric matrix that encompasses anti-K-RasG12D drug, placed with Endoscopic US biopsy and designed to continuously release drug regionally over a period of 4 months. Methods: Open label phase I study patients locally advanced non-operable PDAC first-line setting....
Background. Clostridial infection following pregnancy may be fatal, and surgery is considered as the treatment of choice. We suggest a conservative management in selected cases when preservation fertility major importance. Case. A 41-year-old primigravida presented with abdominal pain fever, one day dilatation curettage at 20 weeks gestation. Her abdomen was diffusely tender, uterus enlarged to weeks' Laboratory studies were consistent sepsis hemolysis. CT demonstrated gas-containing mass...
The extent and clinical manifestations of acute human parvovirus B19 (B19) infection were assessed in previously healthy hospitalized children admitted with syndromes potentially associated the virus.The study was prospective conducted between October 2002 August 2004 pediatric departments 3 hospitals Israel. survey included who 1 or more following diseases: nonallergic exanthema, fever for >1 week, aplastic anemia pancytopenia, nonbacterial arthropathy, immune thrombocytopenic purpura...
Systemic hypertension (secondary to aortic coarctation) produces in monkeys, multifocal brain lesions where capillaries show increased diameter, endothelial degeneration and deposition of collagen other substances the basement membrane. In one animal, capillary changes were detected as early 8 weeks after induction hypertension. Similar alterations demonstrated samples hypertensive humans obtained at autopsy. We suggest that above abnormalities may be result successive episodes regional...
Objective This study was aimed to determine the utility of quantitative dynamic contrast-enhanced magnetic resonance imaging (MRI) in differentiating benign and malignant lesions patients with known thyroid gland scheduled for resection. Methods Patients resection a mass were prospectively enrolled. Dynamic MRI scans neck performed before surgery. After resection, divided into groups. Quantitative semiquantitative kinetic measurements compared analyzed. Results Twelve 9 identified 19...
A Tc-99m HM-PAO brain SPECT study of a patient with biopsy-proven Creutzfeld-Jakob disease demonstrated perfusion defects in the left frontal and right temporoparietal areas. CT was normal. The clinical potential this imaging modality evaluation dementia is discussed.
Purpose: To prospectively characterize and optimize radiofrequency energy deposition to determine ideal parameters for achieving large ablation zones.Materials methods: An internally-cooled RF system was used perform 214 ablations in 72 ex-vivo bovine livers. Tip exposure (1–5 cm), electrode current (400–2500 mA), application duration (3–15 min) were systematically varied. A pulsing algorithm optimized efficiency of deposition, including initial automatic ramping followed by adjustment...
Conventional magnetic resonance imaging (MRI) neuroimaging of infants is complicated by the need to transport outside neonatal intensive care unit (NICU), often distant areas hospital.The main aim this study was evaluate and compare scoring images from a novel 1T MRI, which enables within NICU, with those conventional MRI.The second document improved expediency, thereby greater patient safety, as reflected decreased time.Thirty premature (mean gestational age: 28.8 ± 2.1 weeks) were scanned...
PD : Parkinson disease (PD) is a degenerative disorder of the nervous system. It characterized by loss dopamine-producing cells which, in time, develops into motor system dysfunction. A small portion cases are purely genetic. Currently, diagnosis based on clinical
270 Background: K-Ras mutation G12D is most prevalent in pancreatic adenocarcinoma (PDAC). siRNA against the (siG12D) mutant had showed significant preclinical anti-tumor effects. siG12D LODER - a miniature biodegradable polymeric matrix that encompasses anti K-RasG12D drug, designed to release drug regionally along 4 months. The placed with Endoscopic US biopsy. Methods: Open label phase I study of patients locally advanced non-operable PDAC first-line setting. Patients were assigned...
Purpose To study the effects of surrounding electrical microenvironment and local tissue parameters on outcome irreversible electroporation (IRE) ablation in porcine muscle, kidney, liver tissue. Materials Methods Animal Care Use Committee approval was obtained, National Institutes Health guidelines were followed. IRE (n = 90) applied muscle 44), kidney 28), 18) 18 pigs. Two electrodes with tip exposure 1.5–2 cm used at varying voltages (1500–3000 V), pulse repetitions 70–100), length...
Congenital cholesteatomas are epidermoid cysts that develop from epithelial remnants within the temporal bone. While commonly diagnosed in children, adult presentations rare and can pose diagnostic challenges. We present a 53-year-old man with nine-month history of right-sided facial paralysis, hearing loss, headaches. Examination revealed House-Brackmann grade VI nerve dysfunction. Imaging showed an expansile lesion involving mastoid, eroding otic capsule, canal, tegmen extension into...