A5102941412- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Hepatitis C virus research
- Liver Disease and Transplantation
- Metastasis and carcinoma case studies
- Cardiovascular Disease and Adiposity
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Alcohol Consumption and Health Effects
- Pancreatitis Pathology and Treatment
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Folate and B Vitamins Research
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Liver Diseases and Immunity
- Pregnancy and Medication Impact
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Inflammasome and immune disorders
Istanbul Memorial Hospital
2023
Gentofte Hospital
2023
Istanbul Medeniyet University
2012-2022
Cleveland Clinic Florida
2015-2022
Medeniyet Üniversitesi Göztepe Eğitim ve Araştırma Hastanesi
2012-2017
Marmara University
2015
GTx (United States)
2012
Istanbul Eye Hospital
2011-2012
Istanbul University
2009-2010
Crohn's disease (CD) decreases fertility both directly, by inducing inflammation in the fallopian tubes and ovaries, indirectly, through surgical interventions tubal adhesions associated with treatment. Anti-müllerian hormone (AMH) is a reliable indicator of ovarian reserve women. We aimed to compare serum AMH levels between reproductive-age women CD healthy controls.Serum were measured ELISA 35 age-matched controls.CD patients controls similar terms age, height, weight BMI. Mean duration...
Research suggests the presence of mild-to-moderate iron overload in patients with nonalcoholic fatty liver disease (NAFLD). The role played by hepcidin, master regulatory hormone systemic metabolism, pathogenesis NAFLD remains controversial. aims this study were to: (1) Evaluate serum hepcidin levels biopsy-proven and age- sex-matched controls (2) identify potential associations clinical biochemical characteristics participants.Serum measured enzyme-linked immunosorbent assay compared 88 (56...
Background Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). We aimed evaluate left ventricular (LV) systolic function using two-dimensional speckle-tracking echocardiography (2D-STE) in patients with NAFLD and investigate whether any changes exist among the subgroups of NAFLD. Materials methods included 55 21 healthy controls. The diagnosis was made on basis biopsy. After were categorized into groups...
Currently, nonalcoholic fatty liver disease (NAFLD) itself has been accepted as an atherosclerotic risk factor and related to increased cardiovascular risk. In this study, we aimed investigate the relationship of epicardial fat thickness (EFT), a parameter associated with atherosclerosis in recent years, carotid artery intima-media (C-IMT), another subclinical atherosclerosis.We investigated 57 patients biopsy-proven NAFLD 30 age-matched sex-matched controls. EFT was obtained by...
Recent studies have suggested that bacterial overgrowth and endotoxemia along with its receptor, Toll-like receptor 4 (TLR-4), play a role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The present study was designed to test evaluate TLR4 gene polymorphism patients NAFLD comparison healthy controls.A total 119 [mean (standard deviation, SD) age 43.4 (11.5) years, 55.5% were males] 80 controls (SD) 40.9 (8.1) 67.5% females)] evaluated terms patient demographics,...
Background/Aims: We sought to examine whether the presence of gallstone disease (GD) in patients with biopsy-proven nonalcoholic fatty liver (NAFLD) is associated fibrosis and histological steatohepatitis (NASH) score.Methods: included 441 Turkish NAFLD.GD was diagnosed sonographic evidence gallstones, echogenic material within gallbladder constant shadowing little or no visualization absence at ultrasonography, coupled a history cholecystectomy.Results: Fifty-four (12.2%) had GD (GD+...
In this study, we aimed to investigate the relationship between histological features of nonalcoholic fatty liver disease (NAFLD) and serum insulin-like growth factor-1 (IGF-1) factor-binding protein-5 (IGFBP-5) determine usefulness in clinical practice.Serum samples were collected from 92 patients with biopsy-proven NAFLD 51 healthy controls levels IGF-1 IGFBP-5 assayed by enzyme-linked immunosorbent assay.Serum correlated steatosis, fibrosis, steatohepatitis scores. significantly decreased...
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome (MS). However, not all patients with MS will develop NAFLD and have MS. We sought to investigate differences between biopsy-proven without MS.A total 357 consecutive were analysed. Of them, 216 had nonalcoholic steatohepatitis (NASH) 96 a fibrosis score ≥ 2. The was defined as 3 ATP III criteria.A 214 met criteria for MS, while remaining 143 did not. In homeostasis model insulin resistance (P = 0·03;...
The presence of the metabolic syndrome is a strong predictor for NASH (non-alcoholic steatohepatitis) in patients with NAFLD fatty liver disease). In present study, we assessed LA (left atrial) deformation parameters using 2D-STE (speckle tracking echocardiography) and to investigate if any changes exist between subgroups NAFLD. A total 55 21 healthy controls were included study. diagnosis was based on biopsy. After categorized into groups according histopathological analysis (simple...
Obesity is a major health and economic problem, its prevalence has increased dramatically throughout the world [[1]Elrazek A.E. Elbanna Bilasy S.E. Medical management of patients after bariatric surgery: principles guidelines.World J Gastrointest Surg. 2014; 6: 220-228PubMed Google Scholar]. This led to an increase in treatment modalities, which results weight loss by restriction food intake, as well some poorly understood neurohumoral changes gut–brain axis. Carcinoid tumor rare neoplasm,...
Background and aims. Syndecan-1 (CD138) is a transmembrane heparan sulfate proteoglycan expressed in the liver which may exert metabolic effects by mediating hepatic clearance of triglyceride-rich lipoproteins. In present study, we assayed serum levels expression syndecan-1 examined their association with clinical, biochemical, histologic phenotypes patients histology-proven nonalcoholic fatty disease (NAFLD). Methods. A total 59 biopsy-proven NAFLD 54 matched controls were enrolled. The...
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and one most common causes chronic disease, worldwide. Lipoprotein-associated phospholipase A2 (Lp-PLA2) was recently characterized as a novel inflammatory biomarker that correlated with several components constituting syndrome.In this study, we determined serum levels Lp-PLA2 in patients definite nonalcoholic steatohepatitis (NASH, n=25), borderline NASH (n=22), simple (n=10), healthy controls...
Yasar Colak, Gulcin Bozbey, Tolga Erim, Ozge Telci Caklili, Celal Ulasoglu, Ebubekir Senates, Hasan Huseyin Mutlu, Banu Mesci, Mehmet Sait Do?an, Guralp Tasan, Feruze Yilmaz Enc, and Ilyas Tuncer. J Neurogastroenterol Motil 2016;22:470-6. https://doi.org/10.5056/jnm15159
Aim: Our study aimed to examine the relationship of visceral adiposity index (VAI) with clinical and histological parameters in biopsy-proven nonalcoholic fatty liver disease (NAFLD) cases evaluate its place practice. Materials Methods: The included 57 NAFLD healthy controls. VAI values were calculated formula based on body mass index, waist circumference, triglycerides, high-density lipoprotein cholesterol levels. relationships between examined. Results: While was significantly higher...
Fibrinogen-like protein 2 (fgl2), has recently been identified as a new member of the fibrinogen-like family proteins. In this study we assayed plasma levels fgl2 in patients with biopsy proven non-alcoholic fatty liver disease (NAFLD) and examined their association clinical, biochemical histological phenotypes.Levels were measured by enzyme linked immunosorbent assay compared between groups. Moreover, concentrations assessed relation to general characteristics participants results...