A5101777875- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Lipid metabolism and disorders
- Diabetes and associated disorders
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Drug-Induced Hepatotoxicity and Protection
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Microscopic Colitis
- Folate and B Vitamins Research
- Congenital gastrointestinal and neural anomalies
- Connective Tissue Growth Factor Research
- Electronic Health Records Systems
- Heavy Metals in Plants
- Telemedicine and Telehealth Implementation
- Sirtuins and Resveratrol in Medicine
- Biliary and Gastrointestinal Fistulas
- Celiac Disease Research and Management
- Abdominal vascular conditions and treatments
- Surgical Sutures and Adhesives
Biruni University
2019-2024
Sağlık Bilimleri Üniversitesi
2020-2022
Ümraniye Eğitim ve Araştırma Hastanesi
2014-2022
Sivas Cumhuriyet Üniversitesi
2021
Istanbul Medeniyet University
2012-2017
State Hospital
2016
Suleyman Demirel University
2016
Süleyman Demirel University
2016
Istanbul University
2015
Marmara University
2015
Research suggests the presence of mild-to-moderate iron overload in patients with nonalcoholic fatty liver disease (NAFLD). The role played by hepcidin, master regulatory hormone systemic metabolism, pathogenesis NAFLD remains controversial. aims this study were to: (1) Evaluate serum hepcidin levels biopsy-proven and age- sex-matched controls (2) identify potential associations clinical biochemical characteristics participants.Serum measured enzyme-linked immunosorbent assay compared 88 (56...
Currently, nonalcoholic fatty liver disease (NAFLD) itself has been accepted as an atherosclerotic risk factor and related to increased cardiovascular risk. In this study, we aimed investigate the relationship of epicardial fat thickness (EFT), a parameter associated with atherosclerosis in recent years, carotid artery intima-media (C-IMT), another subclinical atherosclerosis.We investigated 57 patients biopsy-proven NAFLD 30 age-matched sex-matched controls. EFT was obtained by...
In this study, we aimed to investigate the relationship between histological features of nonalcoholic fatty liver disease (NAFLD) and serum insulin-like growth factor-1 (IGF-1) factor-binding protein-5 (IGFBP-5) determine usefulness in clinical practice.Serum samples were collected from 92 patients with biopsy-proven NAFLD 51 healthy controls levels IGF-1 IGFBP-5 assayed by enzyme-linked immunosorbent assay.Serum correlated steatosis, fibrosis, steatohepatitis scores. significantly decreased...
Hepatitis B virus (HBV) is a global health problem, and infected patients if left untreated may develop cirrhosis eventually hepatocellular carcinoma. This study aims to enlighten pathways associated with HBV related liver fibrosis for delineation of potential new therapeutic targets biomarkers.Tissue samples from 47 different fibrotic stages (F1 F6) were enrolled 2D-DIGE proteomic screening. Differentially expressed proteins identified by mass spectrometry verified western blotting....
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and one most common causes chronic disease, worldwide. Lipoprotein-associated phospholipase A2 (Lp-PLA2) was recently characterized as a novel inflammatory biomarker that correlated with several components constituting syndrome.In this study, we determined serum levels Lp-PLA2 in patients definite nonalcoholic steatohepatitis (NASH, n=25), borderline NASH (n=22), simple (n=10), healthy controls...
To analyze the relationship between serum lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) levels and clinical histopathological features of biopsy-confirmed nonalcoholic fatty liver disease (NAFLD) patients.Fifty-three consecutive, biopsy-proven NAFLD patients (31 males 22 females, mean age 42.5 ± 9.6 years) 26 age- gender-matched, healthy controls (14 12 39 10.7 were included. The with consecutive who had been admitted to hepatology outpatient clinic within last year...
Toluene is an organic solvent that toxic to humans. Caffeic acid phenethyl ester (CAPE) and thymoquinone (TQ) exhibit antioxidant antitoxic effects. We investigated the protective effects of CAPE TQ on toluene induced hepatotoxicity. Wistar albino rats were divided into seven groups eight. The animals injected intraperitoneally (i.p.) with 0.1 ml/10 g/day corn oil (control I), + 2 ml/kg/day 10% ethanol II), 20 mg/kg/day dissolved in g (TQ), 10 µmol/kg/day (CAPE), 500 (T), together (T TQ), or...
Fibrinogen-like protein 2 (fgl2), has recently been identified as a new member of the fibrinogen-like family proteins. In this study we assayed plasma levels fgl2 in patients with biopsy proven non-alcoholic fatty liver disease (NAFLD) and examined their association clinical, biochemical histological phenotypes.Levels were measured by enzyme linked immunosorbent assay compared between groups. Moreover, concentrations assessed relation to general characteristics participants results...
Aim: In this study, we aimed to investigate the relationship between histological fibrosis stage of nonalcoholic fatty liver disease (NAFLD) and serum connective tissue growth factor (CTGF) determine usefulness in clinical practice. Methods: Serum samples were collected from 51 patients with biopsy-proven NAFLD 28 healthy controls, levels CTGF assayed by ELISA. Results: Levels significantly higher compared controls ( P = 0.001). The increased, that correlated stage, [in no (stage 0) 308.2 ±...
Hepatitis B reactivation (HBVR) is an important risk of treatment with tumor necrosis factor inhibitors (anti-TNF). While antiviral prophylaxis recommended before in HBsAg-positive patients, there no clear approach for the follow-up or prophylactic patients past hepatitis virus (HBV) infection. The aim this study was to evaluate HBV infection treated anti-TNF HBVR and/or HBVR-associated biochemical breakthrough.Patients who received therapy and had (HBsAg negative, anti-HBc IgG positive,...
This study investigated the relationship between size of gastroesophageal varices and platelet count/spleen diameter ratio in cirrhotic patients.The present included 186 patients whom were seen during upper gastrointestinal system endoscopy. Clinical features, laboratory parameters, endoscopy, abdominal ultrasonographic findings evaluated retrospectively. Platelet (P/S) was calculated by dividing number platelets complete blood count (CBC) to largest spleen. Varices classified as small,...
Several risk scores have been developed to predict hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. The majority of are based on pretreatment variables that no longer considered factors for HCC development due the suppression virus replication early course potent antiviral treatment most PAGE-B score, which is platelet levels, age and sex, has shown accurately CHB patients various populations.We aimed evaluate score predicting Turkish treatment.In this study, we...
Aim: This study aimed to present the outcomes in terms of efficacy and complications POEM procedure adult patients diagnosed with achalasia investigate potential effects traditional risk factors such as age, gender, obesity on these outcomes.
 Material Methods: A total 51 who underwent a were retrospectively evaluated from January 2021 July 2023. The main outcome measured was rate clinical success, determined by achieving an Eckardt score 3 or lower two months after procedure. Secondary...