A5051802152- Tryptophan and brain disorders
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Mental Health Research Topics
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Computational Drug Discovery Methods
- Toxoplasma gondii Research Studies
- Cultural and Sociopolitical Studies
- Intensive Care Unit Cognitive Disorders
- Electroconvulsive Therapy Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cytomegalovirus and herpesvirus research
- Genetic Neurodegenerative Diseases
- Turkish Literature and Culture
- Genetics and Neurodevelopmental Disorders
- Nuclear Receptors and Signaling
- Hypothalamic control of reproductive hormones
- Posttraumatic Stress Disorder Research
- Homelessness and Social Issues
University of the Sunshine Coast
2020-2025
Sunshine Coast University Hospital
2021-2024
University of Maryland, Baltimore
2011-2020
University of Maryland, College Park
2017
Notre Dame of Maryland University
2016-2017
VistaGen Therapeutics (United States)
2015
National Institute of Mental Health
2015
National Institutes of Health
2015
University of Baltimore
2012
The University of Texas at Austin
2007
The forced swim test is a rodent behavioral used for evaluation of antidepressant drugs, efficacy new compounds, and experimental manipulations that are aimed at rendering or preventing depressive-like states. Mice placed in an inescapable transparent tank filled with water their escape related mobility behavior measured. straightforward to conduct reliably it requires minimal specialized equipment. Successful implementation the adherence certain procedural details minimization unwarranted...
The tail-suspension test is a mouse behavioral useful in the screening of potential antidepressant drugs, and assessing other manipulations that are expected to affect depression related behaviors. Mice suspended by their tails with tape, such position it cannot escape or hold on nearby surfaces. During this test, typically six minutes duration, resulting oriented behaviors quantified. valuable tool drug discovery for high-throughput prospective compounds. Here, we describe details required...
The tail-suspension test is a mouse behavioral useful in the screening of potential antidepressant drugs, and assessing other manipulations that are expected to affect depression related behaviors. Mice suspended by their tails with tape, such position it cannot escape or hold on nearby surfaces. During this test, typically six minutes duration, resulting oriented behaviors quantified. valuable tool drug discovery for high-throughput prospective compounds. Here, we describe details required...
Currently approved antidepressant drug treatment typically takes several weeks to be effective. The noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist ketamine has shown efficacy as a rapid-acting of depression, but its use is associated with significant side effects. We assessed effects following blockade the glycineB co-agonist site NMDA receptor, located on GluN1 subunit, by selective full 7-chloro-kynurenic acid (7-Cl-KYNA), delivered systemic administration brain-penetrant...
Toxoplasma gondii (T. gondii), a protozoan parasite that persists in host tissues, including brain, has been associated with several psychiatric disorders and suicidal behavior. We sought to test the hypothesis latent T. infection, as manifest by circulating immunoglobulin G (IgG) antibodies gondii, is both categorical dimensional measures of aggression.IgG were collected between 1991 2008 from 358 adult subjects DSM-5 intermittent explosive disorder (IED), non-IED (psychiatric controls), or...
Abstract Recently, low-dose ketamine has been proposed as a rapid-acting treatment option for suicidality. The majority of studies to date have utilised intravenous (IV) ketamine, however, this route administration limitations. On the other hand, oral can be administered in range settings, which is important treating suicidality, although safety and feasibility are lacking. n = 32 adults (aged 22–72 years; 53% female) with chronic suicidal thoughts participated Oral Ketamine Trial on...
The forced swim test is a rodent behavioral used for evaluation of antidepressant drugs, efficacy new compounds, and experimental manipulations that are aimed at rendering or preventing depressive-like states. Mice placed in an inescapable transparent tank filled with water their escape related mobility behavior measured. straightforward to conduct reliably it requires minimal specialized equipment. Successful implementation the adherence certain procedural details minimization unwarranted...
Objective Chronic, low‐level inflammation is associated with symptomatic bipolar disorder ( BD ) and chronic insomnia. Disrupted sleep a feature of episodes both mania depression. We examined the effect neopterin, marker cellular immune activation, kynurenine KYN ), an inflammatory byproduct serotonin pathway, on association between total time depression severity in . Method Twenty‐one participants 28 healthy controls HC were recruited followed during usual clinical care. At baseline after...
Ketamine has been investigated as a treatment alternative for PTSD the last 20 years, yet there have virtually no reports of biological changes or biomarker characterisation related to treatment. To address this significant gap, study analysed blood samples from 25 participants with who took part in an open-label 6-week trial low dose oral ketamine Serum and plasma were quantified before after brain-derived neurotrophic factor (BDNF), vascular endothelial growth A (VEGF-A), serotonin, FK506...
Ketamine has considerable therapeutic potential in alleviating major depressive disorder and chronic suicidality. However, the clinical diagnosis of neuropsychiatric disorders requires more robust diagnostic criteria. Electroencephalography (EEG) shown promise classifying suicidal patients from healthy individuals. The present study aimed to identify changes spectral properties EEG with suicidality after completing 6-week Oral Trial on Suicidality follow-up occurring 4 weeks final ketamine...
Chronic lithium treatment effectively reduces behavioral phenotypes of mania in humans and rodents. The mechanisms by which exerts these actions are poorly understood. Pre-clinical clinical evidence have implicated increased mesolimbic dopamine (DA) neurotransmission with mania. We used fast-scan cyclic voltammetry to characterize changes extracellular DA concentrations the nucleus accumbens (NAc) core evoked 20 60 Hz electrical stimulation ventral tegmental area (VTA) C57BL6/J mice treated...