A5039722694- Malaria Research and Control
- Mosquito-borne diseases and control
- Drug-Induced Hepatotoxicity and Protection
- Computational Drug Discovery Methods
- Parasites and Host Interactions
- Diverse Scientific Research Studies
- HIV/AIDS drug development and treatment
- Vector-borne infectious diseases
- Hemoglobinopathies and Related Disorders
- Liver Disease and Transplantation
- Hepatitis C virus research
- Natural product bioactivities and synthesis
- Viral Infections and Vectors
- Ethnobotanical and Medicinal Plants Studies
- Drug Transport and Resistance Mechanisms
- Biological Stains and Phytochemicals
- Travel-related health issues
- Research on Leishmaniasis Studies
University of Buea
2018-2024
University of Bamenda
2022-2023
Université de Yaoundé I
2015-2022
Artemether-lumefantrine and artesunate-amodiaquine are first-line treatment for uncomplicated malaria in Cameroon. No study has yet compared the efficacy of these drugs following WHO recommended 42-day follow-up period. The goal this was to compare clinical efficacy, tolerability safety (ASAQ), artemether-lumefantrine (AL) dihydroartemisinin piperaquine (DHAP) among children aged less than ten years two malaria-endemic ecological regions Cameroon.A three-arm, randomized, controlled,...
Background . As a result of the spread parasites resistant to antimalarial drugs, Malaria treatment guidelines in Cameroon evolved from nonartemisinin monotherapy artemisinin-based combination therapy. The aim this study was assess effect these therapy changes on prevalence molecular markers resistance 2003 2013 Mutengene, Cameroon. Methodology Dry blood samples (collected 2003–2005 and 2009–2013) were used for parasite DNA extraction. Drug genes amplified by PCR hybridized with...
Background . Despite recommendation from the World Health Organization that all malaria suspected patients undergo a parasitological confirmation using rapid diagnostic test or light microscopy prior to treatment, health facilities in remote endemic settings sometimes resort presumptive diagnosis of for clinical management various reasons. Following observation this practice, we undertook cross-sectional study aimed at comparing based on axillary temperature, SD Bioline™ test, and as...
Abstract Background The Mount Cameroon area has experienced a 57.2% decline in confirmed malaria cases between 2006 and 2013 with the implementation of different control measures but, disease is still public health concern. objective study was to assess burden asymptomatic sub-microscopic Plasmodium infection, altitudinal influence on it, their effect haematological parameters as well identify risk factors infection. Methodology A cross-sectional community-based survey involving 1319...
The current guidelines for malaria prevention and control during pregnancy in Africa is predicated on the of infection and/or disease through intermittent preventive treatment (IPTp), insecticide-treated nets (ITNs) effective case diagnosis management. Concerns that increasing SP resistance some areas SSA may have compromised IPTp-SP efficacy prompted this contemporaneous study, designed to assess prevalence risk factors sub-microscopic parturient women low transmission season Mutengene, a...
Plasmodium falciparum produces histidine-rich protein 2/3 (Pfhrp2/3) genes that accumulate to high levels in the bloodstream and serve as a diagnostic prognostic marker for malaria. Pfhrp2/3 gene deletions may lead false-negative rapid test (RDT) results. We aimed determine prevalence of pfhrp2/3 P. isolates implications RDT use Mount Cameroon region.A cross-sectional hospital-based study with malaria diagnosis performed using microscopy, nested polymerase chain reaction (nPCR). In total,...
Malaria burden is primarily owing to resistance of parasites and vectors frontline drugs insecticides, respectively. Increasing awareness factors contributing parasite antimalarials within communities crucial. This study assessed how community knowledge, attitudes, practices (KAPs) influence antimalarial across four malaria ecological zones in Cameroon.
Abstract Background Many studies have reported high efficacy and safety of artesunate - amodiaquine (AS AQ) artemether lumefantrine (AL) when administered under direct observation in Cameroon. There is paucity data to support their continuous use home based treatment uncomplicated Plasmodium falciparum malaria Hence, this study aimed assess the effectiveness AS AQ versus AL for P . among children 6 – 120 months Yaoundé, Methods A two arm, open label, randomized, controlled trial comparing...
Abstract Background Plasmodium falciparum resistance to intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) continues spread throughout sub-Saharan Africa. This study assessed the occurrence of microscopic and sub-microscopic P. parasitaemia, dihydropteroate synthase mutations associated SP maternal anaemia in Mount Cameroon area. Methods Consenting pregnant women living semi-rural semi-urban/urbanized settings were enrolled this cross-sectional study....
Background: There was an increase in the number of malaria cases Cameroon 2018 that could reflect changes provider practice, despite effective interventions. In this study, we assessed diagnostic performance two rapid tests (mRDTs) for confirmation suspected public and private health facilities transmission settings Cameroon. Methods: We evaluated CareStart pf SD Bioline Pf/PAN mRDT compared these parameters by RDT type setting. Nested PCR blood film microscopy were used as references. The...
The onset and rapid spread of chloroquine resistance the introduction amodiaquine for treatment uncomplicated malaria in Cameroon have influenced proportion Plasmodium falciparum sensitive resistant alleles related to 4-aminoquinoline drugs. This study was undertaken determine prevalence markers antimalarial 4-aminoquinolines Douala Littoral Region, Buea South West Region June 2020. Dry blood spots were prepared from microscopy positive cases used parasite DNA extraction by chelex-100...
Abstract Background Malaria remains endemic in Cameroon, with heterogeneous transmission related to eco-climatic variations, vector diversity and spatial distribution. The intensification of malaria prevention control through the free distribution insecticide-treated nets recent years may have altered composition, geographic natural infection rate Anopheles species, implications for dynamics. present study seeks assess vectorial diversity, dynamics infectivity across different seasons...
Background Despite a scale up of control interventions over the years, malaria remains major public health and economic concern in Cameroon, contributing considerably to hospitalization deaths. The effectiveness strategies depends on extent adherence by population national guidelines. This study assessed influence human knowledge, attitudes, practices related its prevalence parasite infection, with implications for elimination disease. Methodology is cross-sectional community hospital-based...
To assess the antibacterial and cytotoxic properties of stem-barks Feretia apodanthera Erythrophleum ivorense extracts from powdered were prepared following standard techniques marceration, filtration evaporation. Antibacterial activity was assayed against five pathogenic bacteria strains by well-diffusion broth microdilution methods. Cytotoxicity measured acute toxicity test on female albino rats confirmed cell viability assay using 3T3 lines. Phytochemical analysis performed techniques....
Abstract Background: The Mount Cameroon area has experienced a 57.2% decline in confirmed malaria cases between 2006 and 2013 with the implementation of different control measures but, disease is still public health concern. objective study was to assess burden asymptomatic sub-microscopic Plasmodium infection, altitudinal influence on it, their effect haematological parameters as well identify risk factors infection. Methodology: A cross-sectional community-based survey involving 1319...
Drug-resistant malaria parasites pose a threat to global control efforts, and it is important know the extent of these drug-resistant mutations in each region determine appropriate measures. Chloroquine (CQ) was widely used Cameroon for decades, but its declining clinical efficacy due resistance prompted health authorities 2004 resort artemisinin-based combination therapy (ACT) as first-line treatment uncomplicated malaria. Despite numerous efforts malaria, persists, emergence spread ACTs...
Knowledge of the genetic diversity leading malaria vaccine candidate genes in various geographical regions is very essential for development a successful vaccine. This study aimed at assessing haplotype variation Plasmodium falciparum thrombospondin-related adhesive protein (PfTRAP) gene isolates from Buea, Cameroon. Parasitized blood samples were collected on whatmann filter papers by finger pricks 291 participants. infection was assessed thick and thin films. DNA isolated spots using...
Objective: Artemisinin combination therapies(ACT) for the treatment of malaria have shown very high cure rates and with little side effects since it was introduced less that two decades ago. Continuous monitoring these drugs could sustain this efficacy . In study we collected results from many studies evaluate safety to estimate combined 2006 2018. Methods: searched published articles databases all known websites publish articles. We also included unpublished data dissertations. used R...