A5088013281- Mass Spectrometry Techniques and Applications
- Analytical chemistry methods development
- Forensic Toxicology and Drug Analysis
- Analytical Chemistry and Chromatography
- Advanced Chemical Sensor Technologies
- Petroleum Processing and Analysis
- Metabolomics and Mass Spectrometry Studies
- Pesticide Residue Analysis and Safety
- Toxic Organic Pollutants Impact
- Laser-induced spectroscopy and plasma
- Hydrocarbon exploration and reservoir analysis
- Opioid Use Disorder Treatment
- Analytical Chemistry and Sensors
- Ion-surface interactions and analysis
- Photonic and Optical Devices
- Water Quality Monitoring and Analysis
- Optical Network Technologies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Atmospheric chemistry and aerosols
- Pharmaceutical and Antibiotic Environmental Impacts
- Effects and risks of endocrine disrupting chemicals
- Forensic Fingerprint Detection Methods
- HIV, Drug Use, Sexual Risk
- Luminescence and Fluorescent Materials
- Advancements in PLL and VCO Technologies
University of Victoria
2015-2025
Vancouver Island University
2015-2025
University of Washington
2017-2025
Canadian Centre on Substance Use and Addiction
2025
Simon Fraser University
2017-2024
Seattle University
2021
Nanao hospital
2018-2019
University of British Columbia
1991-1998
Los Alamos National Laboratory
1995-1997
Los Alamos National Security (United States)
1996-1997
Drug checking services for harm reduction and overdose prevention have been implemented in many jurisdictions as a public health intervention response to the opioid crisis. This study demonstrates first on-site use of paper spray mass spectrometry quantitative drug address limitations current testing technologies.
In British Columbia, Canada, illicit opioids have been increasingly combined with etizolam, a benzodiazepine analog, that continues to challenge popular portable drug checking technologies as it is often present in low concentrations result of its high potency. An unknown combination and benzodiazepines may dangerous consequences due unpredictable dosing, increased respiratory depression, complicated overdose response measures.Surface-enhanced Raman spectroscopy (SERS) using spectrometer...
Rationale Drug overdose deaths due to fentanyls and other novel psychoactive substances (NPS) are on the rise. The higher potencies of fentanyl analogs compared with morphine require new technologies identify quantitate NPS. Methods Paper spray tandem mass spectrometry (MS/MS) high‐resolution were used measure as well common drugs abuse in urine samples from substance use disorder clinics. Ten‐microliter deposited directly paper cartridges previously loaded internal standards, dried,...
The oxidative transformation product of a common tire preservative, identified as N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ), has recently been found to contribute "urban runoff mortality syndrome" in Coho salmon at nanogram per liter levels. Given the number fish-bearing streams with multiple stormwater inputs, large-scale campaigns identify 6-PPDQ sources and evaluate mitigation strategies will require sensitive, high-throughput analytical methods. We report...
There has been a recent increase in adulteration of opioids with low concentration actives such as fentanyl analogues and benzodiazepines. As drug checking projects using vibrational spectroscopy continue to seek confirmatory lab-based testing, the concern reality missing these potentially harmful substances point-of-care testing is prevalent.A portable GC-MS was used analyze select opioid samples acquired at service Victoria, Canada (n=59). Certified reference standards several...
Drug checking uses analytical chemistry technologies to report on the composition of drugs from unregulated market reduce substance use-related risks, while additionally allowing for monitoring and reporting supply. In context an overdose crisis linked fentanyl, we used drug data examine variability within illicit opioid supply.In this time-series analysis, was collected a service in Victoria, Canada November 2020 July 2021. Drugs reported as opioids by participants (N = 454) were analyzed...
Infrared absorption spectroscopy and surface-enhanced Raman were integrated into three data fusion strategies-hybrid (concatenated spectra), mid-level (extracted features from both datasets) high-level (fusion of predictions models)-to enhance the predictive accuracy for xylazine detection in illicit opioid samples. Three chemometric approaches-random forest, support vector machine, k-nearest neighbor algorithms-were employed optimized using a 5-fold cross-validation grid search all...
Adulteration of the unregulated opioid supply has contributed to increasing numbers overdose deaths in North America. Harm-reduction drug checking emerged as a strategy address adulteration rates by providing information about sample composition people who use drugs. While paper-spray mass spectrometry is capable trace detection for checking, presence newly emerging substances often goes undetected if not included targeted analysis method. High-resolution been widely used drug-checking...
Premixing internal standards (ISTD) with liquid samples prior to paper spray mass spectrometry (PS-MS) analysis consumes unnecessary amounts of ISTD and is not feasible for all sample types applications. Depositing directly on the independently from has been successfully employed in literature but can negatively affect quantitative performance. We evaluated different utilization strategies using drugs misuse as test analytes investigate sources irreproducibility bias. Performance was...
Membrane introduction mass spectrometry (MIMS) is a direct, continuous, on-line measurement technique. It utilizes membrane to semi-selectively transfer analyte mixtures from sample spectrometer, rejecting the bulk of matrix, which can be gas, liquid or solid/slurry. Analyte selectivity and sensitivity are affected by optimizations at membrane, ionization spectrometer levels. MIMS roughly classified acceptor phase that entrains analyte(s) after transport, either gaseous (GP-MIMS) condensed...
Purpose While there is increasing interest in implementing drug checking within overdose prevention, we must also consider how to scale-up these responses so that they have significant reach and impact for people navigating the unpredictable increasingly complex supplies linked overdose. The purpose of this paper present a distributed model community addresses multiple barriers as response illicit crisis. Design/methodology/approach A detailed description key components provided. This...
Paper surface functionalization with polyamidoamine (PAMAM) dendrimers has been developed for increased sensitivity analysis of proteins by paper spray mass spectrometry (PS-MS). PAMAM is a branched polymeric compound an ethylenediamine core linked to repeating units that generates outer rich in primary amines. These positively charged amine groups can interact electrostatically negatively residues (e.g., aspartate, glutamate) on the protein surface. inner amide moieties also promote...
The tire-derived contaminant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ) was recently identified as a potent toxin to coho salmon (Oncorhynchus kisutch). Studies investigating 6-PPDQ have employed solid-phase extraction (SPE) or liquid–liquid (LLE) with liquid chromatography–mass spectrometry (LC-MS), providing excellent sensitivity and selectivity. However, cleanup pre-enrichment steps (SPE/LLE) followed by chromatographic separation can be time- cost-intensive,...
Drug checking services aim to provide compositional information for the illicit drug supply and are being employed in public health responses extreme rates of overdose associated with fentanyl within street opioids. The technologies used these range from basic qualitative tests, such as immunoassay test strips, comprehensive quantitative analyses, mass spectrometry. In general, there is concern that heterogeneity a mixture adds significant uncertainty when using results based on small...
We report the use of a direct sampling, online analytical approach for determination acid extractable naphthenic acids in complex aqueous samples, known as condensed phase membrane introduction mass spectrometry (CP‐MIMS). The technique employs capillary hollow fibre semi‐permeable probe configured immersion into pH adjusted sample. A continuously flowing methanol acceptor transfers to an electrospray ionization source, operated negative ion mode, whereupon they are analysed by [M–H] − ions....
We report the development and application of a capillary hollow fibre membrane interface using methanol as an acceptor phase to deliver target analytes electrospray ionization source triple quadrupole mass spectrometer. Superior fluid handling systems lead greater signal stability integrity for continuous on‐line monitoring polar charged in complex aqueous samples with detection limits parts‐per‐trillion parts‐per‐billion range. The system can be operated either flow or stopped mode – latter...