A5016248561- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Multiple Myeloma Research and Treatments
- Myxozoan Parasites in Aquatic Species
- Marine Ecology and Invasive Species
- Protein Degradation and Inhibitors
- Protist diversity and phylogeny
- Microbial Community Ecology and Physiology
- Genetics, Bioinformatics, and Biomedical Research
- Malaria Research and Control
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Genetic diversity and population structure
- Cancer-related molecular mechanisms research
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Quinazolinone synthesis and applications
- Environmental DNA in Biodiversity Studies
- Plant nutrient uptake and metabolism
- Glycosylation and Glycoproteins Research
- Aquaculture disease management and microbiota
- Plant Disease Resistance and Genetics
University Hospital Ostrava
2024
Institute of Parasitology
2018-2024
University of Ostrava
2024
Czech Academy of Sciences, Biology Centre
2018-2024
University of South Bohemia in České Budějovice
2023-2024
Czech Academy of Sciences
2020-2022
Environmental sequencing has greatly expanded our knowledge of micro-eukaryotic diversity and ecology by revealing previously unknown lineages their distribution. However, the value these data is critically dependent on quality reference databases used to assign an identity environmental sequences. Existing contain errors struggle keep pace with rapidly changing eukaryotic taxonomy, influx novel diversity, computational challenges related assembling high-quality alignments trees needed for...
Phylogenomic analyses of hundreds protein-coding genes aimed at resolving phylogenetic relationships is now a common practice. However, no software currently exists that includes tools for dataset construction and subsequent analysis with diverse validation strategies to assess robustness. Furthermore, there are publicly available high-quality curated databases designed deep (>100 million years) in the tree eukaryotes. To address these issues, we developed an easy-to-use package,...
Abstract Extramedullary multiple myeloma (EMM) is an aggressive form of (MM). This study represents the most comprehensive next-generation sequencing analysis EMM tumors ( N = 14) to date, uncovering key molecular features and describing tumor microenvironment. We observed co-occurrence 1q21 gain/amplification MAPK pathway mutations in 79% samples, suggesting that these are crucial mutational events development. also demonstrated patients with mutated KRAS at time diagnosis have a...
Abstract PhyloFisher is a software package written primarily in Python3 that can be used for the creation, analysis, and visualization of phylogenomic datasets consist protein sequences from eukaryotic organisms. Unlike many existing pipelines, comes with manually curated database 240 protein‐coding genes, subset previous phylogenetic dataset sampled 304 taxa. The also utilize user‐created proteins, which may more appropriate shallow evolutionary questions. equipped set utilities to aid...
Abstract Background Lineage-specific gene expansions represent one of the driving forces in evolutionary dynamics unique phylum traits. Myxozoa, a cnidarian subphylum obligate parasites, are evolutionarily altered and highly reduced organisms with simple body plan including cnidarian-specific organelles polar capsules (a type nematocyst). Minicollagens, group structural proteins, prominent constituents nematocysts linking Myxozoa Cnidaria. Despite recent advances identification minicollagens...
Abstract Background Lineage-specific gene expansions represent one of the driving forces in evolutionary dynamics unique phylum traits. The obligate parasitic group Cnidaria, Myxozoa, are evolutionarily altered and highly reduced organisms with a simple body plan including cnidarian-specific organelles, polar capsules (a type nematocyst). A prominent constituent nematocysts, linking Myxozoa represents structural proteins, minicollagens. Despite recent advances identification minicollagens...