A5030120748- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Corneal Surgery and Treatments
- Viral gastroenteritis research and epidemiology
- T-cell and B-cell Immunology
- Cancer, Lipids, and Metabolism
- Plant Virus Research Studies
- Transgenic Plants and Applications
- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- Histone Deacetylase Inhibitors Research
- Mesenchymal stem cell research
- Heart Failure Treatment and Management
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Peptidase Inhibition and Analysis
- Neonatal Respiratory Health Research
Case Western Reserve University
2017-2022
Taibah University
2019-2022
University School
2020
The plant virus, cowpea mosaic virus (CPMV), has demonstrated a remarkable capacity to induce anti-tumour immune responses following direct administration into solid tumours. molecular pathways that account for these effects and the of CPMV activate human cells are not well defined. Here, we examine ability particles monocytes, dendritic (DCs) macrophages. Monocytes in peripheral blood mononuclear cell cultures purified CD14+ monocytes were readily activated by vitro, leading induction...
Despite use of newer approaches, some patients being considered for autologous hematopoietic cell transplantation (HCT) may only mobilize limited numbers progenitor cells (HPCs) into blood, precluding the procedure, or placed at increased risk complications due to slow reconstitution. Developing more efficacious HPC mobilization regimens and strategies enhance process improve patient outcome. Although Notch signaling is not essential homeostasis adult stem (HSCs), Notch-ligand adhesive...
Recent studies have implicated a role for adenosine-dependent immunosuppression in head and neck tumor microenvironments. We describe expression of CD73, an enzyme critical to the generation adenosine from extracellular AMP, T cells other cell types within human tumors. Flow cytometric analyses tumor-infiltrating indicate that CD3+ are predominant source CD73 among immune infiltrating expression, especially CD8+ cells, is inversely related indices infiltration activation microenvironment...
Tumor-infiltrating monocytes can mature into Macrophages that support tumor survival or display antitumor properties. To explore mechanisms steering Macrophage maturation, we assessed the effects of supernatants from squamous cell carcinoma lines (FaDu and SCC) on monocyte-derived maturation. Purified were incubated in medium supplemented with FaDu SCC9 leukemia monocytic line, THP-1. examined for markers maturation (CD14, CD68), activation (HLA-DR, CD86, IL15R), scavenger receptor (CD36),...
Abstract Successful hematopoietic progenitor cell (HPC) transplant therapy is improved by mobilizing HPCs from the bone marrow niche in donors. Notch receptor–ligand interactions are known to retain marrow, and neutralizing antibodies against ligands, Jagged-1 or Delta-like ligand (DLL4), NOTCH2 receptor potentiates HPC mobilization. Notch–ligand dependent on posttranslational modification of receptors with O-fucose modulated Fringe-mediated extension moieties. We previously reported that...
Abstract Novel approaches to retrieve and enhance immunity against cancer antigens have been established. One promising approach involves the use of virus particles derived from plant virus, Cowpea Mosaic Virus (CPMV). Injection CPMV into tumor stimulates systemic antitumor in mouse models canine patients with tumors. The molecular pathways that account for these effects are not well defined. In studies, we examine capacity activate human monocytes. Peripheral blood mononuclear cells were...
Abstract Head and neck cancers (HNC) can persist despite infiltration of immune cells into the tumor microenvironment. One mechanism that may contribute to failed clearance tumors stems from conditioning infiltrating macrophages a cell type supports survival rather than with pro-inflammatory characteristics. To understand mechanisms lead by tumors, we assessed effects HNC lines on macrophage maturation. Macrophages were matured incubating purified human monocytes for 3-4 days in medium alone...