A5000916118- Bacteriophages and microbial interactions
- Plant Virus Research Studies
- Transgenic Plants and Applications
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Veterinary Oncology Research
- Polyomavirus and related diseases
- Photodynamic Therapy Research Studies
- Icing and De-icing Technologies
- Calcium Carbonate Crystallization and Inhibition
- Parasitic Infections and Diagnostics
- Nanowire Synthesis and Applications
- Viral gastroenteritis research and epidemiology
- Nanoplatforms for cancer theranostics
- Toxin Mechanisms and Immunotoxins
Case Western Reserve University
2016-2021
University School
2018-2019
The presence and benefit of a radiation therapy-associated immune reaction is great interest as the overall in cancer immunotherapy expands. pathological assessment irradiated tumors rarely demonstrates consistent or inflammatory response. More recent information, primarily associated with "abscopal effect", suggests subtle radiation-based systemic response may be more common have therapeutic potential than previously believed. However, to value, stimulatory therapy (RT) will clearly need...
The plant viral nanoparticle cowpea mosaic virus (CPMV) is shown to be an effective immunotherapy for ovarian cancer when administered as in situ vaccine weekly, directly into the intraperitoneal (IP) space mice with disseminated tumors. While antitumor efficacy promising, required frequency of administration may pose challenges clinical implementation. To overcome this, a slow release formulation developed. CPMV and polyamidoamine generation 4 dendrimer form aggregates (CPMV-G4) based on...
Photodynamic therapy (PDT) is a promising avenue for greater treatment efficacy of highly resistant and aggressive melanoma. Through photosensitizer attachment to nanoparticles, specificity delivery can be conferred further reduce potential side effects. While the main focus PDT destruction cancer cells, additional targeting tumor-associated macrophages also present in tumor microenvironment could enhance by eliminating their role processes such as invasion, metastasis, immunosuppression. In...
It has recently been shown that cancer treatments such as radiation and hyperthermia, which have conventionally viewed to modest immune based anti-cancer effects, may, if used appropriately stimulate a significant potentially effective local systemic effect (abscopal effect) improved prognosis. Using eight spontaneous canine cancers (2 oral melanoma, 3 amelioblastomas 1 carcinomas), we hypofractionated (6 x 6 Gy) and/or magnetic nanoparticle hyperthermia X 43°C / 45 minutes) an immunogenic...
Efficient loading of drugs in novel delivery agents has the potential to substantially improve therapy by targeting diseased tissue while avoiding unwanted side effects. Here we report first systematic study mechanism phenanthriplatin and its analogs into tobacco mosaic virus (TMV), previously used our group as an efficient carrier for anticancer drug delivery. A detailed investigation preferential uptake aquated form (∼2000 molecules per TMV particle versus ∼1000 chlorido form) is provided....
Plant vital nanoparticle PVX shows a binding affinity towards malignant B cells and traffics to metastatic lymphoma sites in mice challenged with cell lymphoma, thus enabling NHL-specific drug delivery.
The plant virus, cowpea mosaic virus (CPMV), has demonstrated a remarkable capacity to induce anti-tumour immune responses following direct administration into solid tumours. molecular pathways that account for these effects and the of CPMV activate human cells are not well defined. Here, we examine ability particles monocytes, dendritic (DCs) macrophages. Monocytes in peripheral blood mononuclear cell cultures purified CD14+ monocytes were readily activated by vitro, leading induction...
Ovarian cancer is the deadliest gynecological malignancy. Though most patients enter remission following initial interventions, relapse common and often fatal. Accordingly, there a substantial need for ovarian therapies that prevent relapse. Following generated by surgical debulking chemotherapy, but prior to relapse, resected inactivated tumor tissue could be used as personalized vaccine antigen source. The patient's own contains relevant antigens and, when combined with appropriate...
Although there is long association of medical hyperthermia and immune stimulation, the relative lack a quantifiable reproducible effect has limited utility advancement this relationship in preclinical/clinical cancer non-cancer settings. Recent cancer-based findings (immune checkpoint modulators etc.) including improved mechanistic understanding biological tools now make it possible to modify exploit system benefit conventional treatments such as radiation hyperthermia. Based on prior...
Abstract The concept of biomineralization and encapsulation organic molecules into inorganic matrices to alter enhance their physical properties has been evolved perfected in natural systems. Being inspired by the foreign components calcite, here inclusion a plant virus, cowpea mosaic virus (CPMV) 5.4% mass crystals calcite is reported. viral particles are labeled with fluorescent tag (Alexa Fluor 532), observed within matrix using confocal fluorescence microscopy. Upon encapsulation,...
Abstract Photon extraction and capture efficiency is a complex function of the material's composition, its molecular structure at nanoscale, overall organization spanning multiple length scales. The architecture material defines performance; nanostructured features within materials enhance energy efficiency. capturing are largely produced through lithographic, top‐down, manufacturing schemes; however, there limits to smallest dimension achievable using this technology. To overcome these...
Ionic inorganic matrices such as calcite are known to occlude ions, organic molecules and proteins, this process is at the core of biomineralization. In article number 1700176, by using labeled cowpea mosaic virus, Panče Naumov co-workers demonstrate that can biomolecules large viruses up several percent mass. The results be applied thermal stabilization vaccines towards elimination “cold chain”.