A5074786774- Vibrio bacteria research studies
- Aquaculture disease management and microbiota
- Cell death mechanisms and regulation
- Fish Biology and Ecology Studies
- Invertebrate Immune Response Mechanisms
- Autophagy in Disease and Therapy
- Parasite Biology and Host Interactions
- Animal Disease Management and Epidemiology
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Phagocytosis and Immune Regulation
- Microbial infections and disease research
- Virus-based gene therapy research
- Environmental Toxicology and Ecotoxicology
- Insect symbiosis and bacterial influences
- Immune Response and Inflammation
- Pediatric Hepatobiliary Diseases and Treatments
- Aquaculture Nutrition and Growth
- Pancreatitis Pathology and Treatment
- Studies on Chitinases and Chitosanases
Instituto de Biologia Molecular e Celular
2005-2010
Universidade do Porto
2006-2010
University of Pittsburgh
2008
Institut de Biologie Moléculaire et Cellulaire
2005
Swansea University
2001-2004
University of Wales
2001-2004
A strategy used by extracellular pathogens to evade phagocytosis is the utilization of exotoxins that kill host phagocytes. We have recently shown one major pathogenicity Photobacterium damselae subsp. piscicida (Phdp), agent widespread fish pasteurellosis, induction extensive apoptosis sea bass macrophages and neutrophils results in lysis these phagocytes post-apoptotic secondary necrosis. Here we show this unique process mediated a novel plasmid-encoded inducing protein 56 kDa (AIP56), an...
Chitinolytic bacteria are believed to be the primary aetiological agents of shell disease syndrome in marine crustaceans. The principally results from breakdown their chitinous exoskeletons by pathogens, but pathogenicity may also manifest internally should a breach carapace occur. current study looks at number (predominantly genus Vibrio) isolated edible crab, Cancer pagurus. All chitinase-producing investigated were capable growth minimal medium consisting chitin powder crab shells,...
Bacterial modulation of phagocyte cell death is an emerging theme in pathogenesis. Here we describe the systemic destruction macrophages and neutrophils by Gram-negative Photobacterium damselae ssp. piscicida (Phdp) fish pasteurellosis, a deadly infection. Following experimental inoculation, Phdp spreads bacteraemia colonizes organs, producing septicaemic infection, secretes apoptogenic exotoxin AIP56 which systemically disseminated. In natural secondary necrosis following...
Shell disease syndrome is characterised by the external manifestation of black spot lesions in exoskeletons crustaceans. In present study, gills, hepatopancreas and hearts from healthy (<0.05% coverage) diseased (5 to 15% edible crabs, Cancer pagurus, were examined histologically determine whether this can cause internal damage such crabs. There was clear evidence cuticular gills crabs leading formation haemocyte plugs termed nodules. Nephrocytes found within branchial septa showed an...
ABSTRACT Previous studies have shown that injection of extracellular products (ECP) Pseudoalteromononas atlantica isolated from shell disease-infected edible crabs ( Cancer pagurus ) into healthy causes rapid death. In this study we examined the nature active lethal factor(s) in ECP. Injection ECP caused a decline total number circulating hemocytes (blood cells), and died within 60 to 90 min. The individuals showed eyestalk retraction, limb paralysis, lack antennal sensitivity, suggesting...