A5070012954- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Molecular Communication and Nanonetworks
- Neural dynamics and brain function
- bioluminescence and chemiluminescence research
- Parasitic Infections and Diagnostics
- HIV Research and Treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Malaria Research and Control
- Health Literacy and Information Accessibility
- Retinal Development and Disorders
- vaccines and immunoinformatics approaches
- Parkinson's Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Breastfeeding Practices and Influences
- Aeolian processes and effects
- Geological formations and processes
- Glycosylation and Glycoproteins Research
- Diet and metabolism studies
- Nicotinic Acetylcholine Receptors Study
Texas Tech University Health Sciences Center
2023
Texas Tech University
2023
Emory University
2016-2022
Abstract Although molecular tools for controlling neuronal activity by light have vastly expanded, there are still unmet needs which require development and refinement. For example, delivery into the brain is a major practical challenge that hinders potential translation of optogenetics in human patients. In addition, it would be advantageous to manipulate acutely precisely as well chronically non‐invasively, using same genetic construct animal models. We previously addressed these...
Developing a new neuromodulation method for epilepsy treatment requires large amount of time and resources to find effective stimulation parameters often fails due inter-subject variability in effect. As an alternative, we present novel data-driven surrogate approach which can optimize the efficiently by investigating effect on neural states.Medial septum (MS) optogenetic was applied modulating electrophysiological activities hippocampus rat temporal lobe model. For approach, implemented...
Objective.Neural modulation is a fundamental tool for understanding and treating neurological psychiatric diseases. However, due to the high-dimensional space, subject-specific responses, variability within each subject, it major challenge select stimulation parameters that have desired effect. Data-driven optimization provides range of different algorithms tools addressing this challenge, but these has specific strengths limitations, therefore must be carefully designed given neural...
A malaria vaccine is a public health priority. In order to produce an effective vaccine, multistage approach targeting both the blood and liver stage infection desirable. The candidates also need induce balanced immune responses including antibodies, CD4+ CD8+ T cells. Protein-based subunit vaccines like RTS,S are able strong antibody response but poor cellular reactivity. Adenoviral vectors have been inducing protective cell in several models malaria; nonetheless this platform exhibits...
Exercise has been extensively studied in Parkinson's Disease, with a particular focus on the potential for neuroprotection that demonstrated animal models. While this preclinical work provided insight into underlying molecular mechanisms, it not addressed neurophysiological changes during exercise. Here, first, we tested neuroprotective effects of adaptive wheel exercise 6-hydroxydopamine mouse model disease. Finding none, probed neurophysiology as state high motor function amidst an...
The need for maternal medications is a known barrier to breastfeeding. Though most are compatible with lactation, healthcare providers use abundant caution, often viewing and breastfeeding as mutually exclusive. A dual intervention of an educational webinar access mobile app lactation pharmacology was used enhance provider familiarity, confidence, knowledge in medication during Surveys were administered before, one week after, three months after the evaluate performance gap improvement....
Abstract Previous studies in human patients and rodent models of Parkinson’s disease (PD) have established neuroprotection dopaminergic (DA) neurons substantia nigra pars compacta (SNC) by physical exercise, but the precise origin this neuroprotective effect has yet to be elucidated. In study, we tested a hypothesis that enhanced activity DA SNC results using unilateral 6-hydroxydopamine (6-OHDA) injection model mice. To increase chronically specifically, injected an adeno-associated viral...