A5014571559- Antioxidant Activity and Oxidative Stress
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- CRISPR and Genetic Engineering
- RNA regulation and disease
- Seaweed-derived Bioactive Compounds
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinoids in leukemia and cellular processes
- RNA Interference and Gene Delivery
- Toxin Mechanisms and Immunotoxins
- Coenzyme Q10 studies and effects
- Adipose Tissue and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Hybrid Renewable Energy Systems
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Heat shock proteins research
- Neurological Disease Mechanisms and Treatments
- Music Technology and Sound Studies
- thermodynamics and calorimetric analyses
- Diversity and Impact of Dance
- Vitamin C and Antioxidants Research
University of Alabama
2021-2023
University of West Florida
2023
National Cancer Institute
2023
National Institutes of Health
2023
Whole-exome sequencing of Parkinson's disease (PD) patient DNA identified single-nucleotide polymorphisms (SNPs) in the tyrosine nonreceptor kinase-2 (
Oxidative stress plays an important role in neuronal loss associated with mitochondrial dysfunction. Excess reactive oxygen species (ROS) production damages mitochondria, impairing energy metabolism. The damaged mitochondria promote aberrant ROS leading to death. Fucoxanthin, a carotenoid antioxidant properties primarily found brown seaweeds, has been shown protect various disease models. However, limited studies have demonstrated the mechanisms of fucoxanthin-mediated neuroprotection. In...
Reactive oxygen species (ROS) are a major contributor to intracellular organelle damage in neurons. ROS-induced mitochondrial dysfunction is highly associated with impaired energy metabolism that occurs during neurodegeneration. Therefore, the use of antioxidants may be beneficial protecting brain from injury caused by ROS. Lycopene carotenoid exhibits neuroprotective properties via its antioxidant capacity. In this study, we hypothesize treatment lycopene attenuates hydrogen...
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Exercise has been extensively studied in Parkinson's Disease, with a particular focus on the potential for neuroprotection that demonstrated animal models. While this preclinical work provided insight into underlying molecular mechanisms, it not addressed neurophysiological changes during exercise. Here, first, we tested neuroprotective effects of adaptive wheel exercise 6-hydroxydopamine mouse model disease. Finding none, probed neurophysiology as state high motor function amidst an...
B-cell lymphoma-extra large (Bcl-xL) is a mitochondrial protein known to inhibit mitochondria-dependent intrinsic apoptotic pathways. An increasing number of studies have demonstrated that Bcl-xL critical in regulating neuronal energy metabolism and has protective role pathologies associated with an deficit. However, it less how regulates physiological processes the brain. In this study, we hypothesize required for neurite branching maturation during development by improving local...
Calpains are a family of calcium and thiol-dependent endo-proteases that selectively cleave substrates. Increased activity calpains is implicated or causal in several diseases conditions, including some forms muscular dystrophy, ischemic stroke, cataracts, Alzheimer's disease. A potential inhibitor, the pentapeptide Leu-Ser-Glu-Ala-Leu (LSEAL), was identified prior work to inhibit calpain I not tested against II. Conflicting data have been observed suggested LSEAL ineffective both The...
Alpha-tocotrienol (α-TCT), a form of vitamin E, is lipophilic antioxidant with neuroprotective properties. We recently reported that α-TCT treatment prevents oxidative stress-induced proteolytic cleavage B-cell lymphoma-extra large (Bcl-xL), pro-survival mitochondrial protein necessary during neuronal growth. However, it still unclear if exhibits beneficial effects the physiological development neurons. In this study, we hypothesized chronic advances primary hippocampal neurons by improving...
Neurite branching is necessary to achieve neurite complexity and synaptic plasticity. Therefore, understanding how neurons utilize intracellular energy support key elucidating cellular mechanisms of neuronal development. B-cell lymphoma extra large (Bcl-xL) a pro-survival protein found in the mitochondria. Traditionally, Bcl-xL known block apoptotic pathway, yet increasing studies have demonstrated that exhibits additional biological roles. has been reported enhance metabolism synapse...
Abstract Whole exome sequencing of Parkinson’s disease (PD) patient DNA identified single-nucleotide polymorphisms (SNPs) in the TNK2 gene. Although encodes a non-receptor tyrosine kinase that has been shown to prevent endocytosis dopamine reuptake transporter (DAT), causal role for PD remains unresolved. We postulated specific recessive mutations patients resulted aberrant or prolonged overactivity as consequence failed negative regulation by an E3 ubiquitin ligase, NEDD4. Interestingly,...
Neurite outgrowth and branching is critical during neuronal development. Failure to achieve proper neurite complexity highly associated with developmental disorders. We have previously shown that oxidative stress contributes alteration of morphology. Therefore, nutrients capable regulating redox balance may help maintain normal recently found lycopene, a nutritional antioxidant, protects mitochondria by preventing generation mitochondrial superoxide. In this study, we hypothesize treatment...
Neurite outgrowth is a foundational process in brain development and recovery from injury. Assembly of the cytoskeleton formation new synapses during neurite requires an abundance energy. We have reported that mitochondrial protein Bcl-xL necessary for arborization. However, undergoes post-translational cleavage oxidative stress resulting product impairs function. Our recent publication demonstrated treatment with alpha-tocotrienol, antioxidant member vitamin E family, prevents protects...
B-cell lymphoma-extra large (Bcl-xL) is a pro-survival protein localized to mitochondria and also reported support brain function by enhancing neuronal energy metabolism synapse formation. We have previously shown that Bcl-xL required for neurite outgrowth, neurons lacking were susceptible against neurotoxic challenges. In this study, we hypothesized supports maintaining ATP regulating mitochondrial motility. thus tested if depletion altered normal dynamics, retention, morphology. Primary...