The close cooperation between breast cancer and cancer-associated adipose tissue (CAAT) shapes the malignant phenotype, but role of mitochondrial metabolic reprogramming obesity in remains undecided, especially premenopausal women. Here, we examined dynamics paired biopsies versus benign tumor CAAT normal-weight overweight/obese Lower protein level pyruvate dehydrogenase citrate synthase indicated decreased carbon flux from glucose into Krebs cycle, whereas trend was just opposite CAAT....

Brown adipose tissue (BAT) has the unique ability of generating heat due to expression mitochondrial uncoupling protein 1 (UCP1). A recent discovery regarding functional BAT in adult humans increased interest molecular pathways development and functionality. An important role for estrogen white was shown, but possible human fetal (fBAT) is unclear.The objective this study determine whether fBAT expresses receptor α (ERα) ERβ. In addition, we examined their localization as well correlation...

Typical features of the breast malignant phenotype rely on metabolic reprogramming cancer cells and their interaction with surrounding adipocytes. Obesity is strongly associated mortality, yet effects obesity cancer-associated adipose tissue remain largely unknown. Paired biopsies tumor from premenopausal women were divided according to pathohistological analyses body mass index normal-weight overweight/obese benign or tumors. We investigated protein expression key regulatory enzymes...

Metabolic syndrome arises from abnormal adipose function accompanied by insulin resistance. As early factors reflecting/impacting lipid storage dysfunction of tissues, we sought to determine adipokine levels in subcutaneous and visceral tissues (SAT VAT).Gene protein expression leptin, adiponectin, resistin were analysed SAT VAT normal-weight overweight/obese women, subclassified according resistance index, triglyceride, total, low-density lipoprotein (LDL) high-density (HDL) cholesterol...

Vitamin D deficiency and dysfunctional adipose tissue are involved in the development of cardiometabolic disturbances (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, dyslipidemia). We evaluated relation between vitamin adipocytokines derived from tissue. studied 50 obese individuals who were classified into different subgroups according to medians observed anthropometric parameters (body mass index, body fat percentage, waist circumference, trunk mass). There was a...

To evaluate the connection between menstrual disorders and body fat mass, we examined a group of 30 ballet dancers non-athletic girls (controls). Body mass index (BMI) was calculated percent (FAT%) measured using bioelectrical impedance method. A questionnaire used to obtain age at menarche duration cycles. Ballet had significantly lower values BMI (18.56 +/- 1.53 vs. 19.96 2.12 kg/m2) FAT% (18.85 4.50 23.41 4.34%) compared with controls. According BMI, 50.0% 23.3% control were underweight....

Background Obesity is a well known risk factor for the development of metabolic abnormalities. However, some obese people are healthy and on other hand with normal weight have adverse profile, therefore it can be assumed that there difference in physical characteristics amongst these people. The aim this study was to establish whether somatotype differences between metabolically women who or weight. Subjects methods Study included 230 aged 44.76 ± 11.21y. Metabolic status assessed according...

Aim Impaired autonomic function could be the mechanism for development of cardiometabolic diseases in obesity. Hence, simple anthropometric measures overall and central obesity screening markers imbalance. We analysed relationship between heart rate variability ( HRV ) parameters indicators. Methods Sixty‐three obese women underwent blood pressure, lipids measurements, body composition assessment, HOMA (homeostasis model assessment) index calculation short‐term analysis. Results The...

Morphological changes in adipose tissue reflect functional disorders that correlate with cardiometabolic complications of obesity. The metabolic risks vary among the obese individuals. Furthermore, normal-weight individuals are not necessarily metabolically healthy. Therefore, aim this study was to analyze morphological characteristics abdominal and regards risks.The group consisted 30 overweight or 20 women undergoing elective surgery. Women each were divided into healthy obese, based on...

Metabolic reprogramming that favors high glycolytic flux with lactate production in normoxia is among cancer hallmarks. Lactate an essential oncometabolite regulating cellular redox homeostasis, energy substrate partitioning, and intracellular signaling. Moreover, malignant phenotype’s chief characteristics are dependent on the interaction between cells their microenvironment. In breast cancer, mammary adipocytes represent component of tumor milieu. We analyzed concentration, dehydrogenase...

Anatomy, one of the key pre-clinical subjects in medical and allied disciplines, has traditionally relied on instruction based utilization cadavers.Acquiring cadavers for anatomy education presented a challenge many countries.This been met through organization well informed culturally sensitive body donation programs.Attitudes general population, professionals students are important devising these programs.The aim this study was to investigate attitudes from University Novi Sad toward whole...

Introduction The aim of this study was to evaluate and compare the nutritional status body composition in female ballet dancers a group non-athletic controls. Materials methods consisted 30 dancers, aged 17.4?2.01, whereas control included examinees, 18.00 years on average. Height weight were measured mass index (BMI) calculated all subjects. Body estimated using bioelectrical impedance method. Results analysis revealed significantly lower values fat compared (18.85?4.50% vs. 23.41?4.34)....

Digit ratio established in utero is positivelly correlated with intrauterine level of estrogen. Since the breast cancer related to excessive and prolonged exposure estrogen, digit might be considered as useful marker risk assessment. The aim present study was compare ratios patients healthy controls. group consisted 98 aged between 29 84 years while control included 141 women 21 67 years. After collecting anamnestic data concerning menopausal status, length second fourth fingers were...

One of the underlying mechanisms that could link breast cancer and obesity is shifted redox homeostasis in tumor microenvironment. To reveal relationship between malignant phenotype obesity, we compared profiles tumor-associated adipose tissue from premenopausal women: normal-weight with benign tumors, overweight/obese tumors. Namely, examined protein expression nuclear factor erythroid 2-related 2 (Nrf2), activity main antioxidant defense (AD) enzymes: copper, zinc- manganese superoxide...

Introduction. Apart from assessing the nutrition status, diagnosis of obesity also includes assessment mass and distribution adipose tissue which provides revealing latent types that hold higher health risks. The aim our study was to assess nutritional status analyze prevalence normal weight abdominal in students University Novi Sad. Material methods. body index, waist circumference fat were assessed group 371 Sad (their average age being 22.9?2.5y). Results. One-fifth sample found be...

Terminologia Anatomica is a unique collection of technical terms that enable communication in anatomy and medicine across the world. However, current anatomical terminology also contains some internal inconsistencies discrepancies regard to clinical terminology. Thus, number are not logically related names similar entities, or corresponding physiological pathological conditions. Moreover, during practice many have commonly been replaced by new, idioms. These terminological represent an...

Nowadays, obesity is one of the most important health problems in both developed and developing countries. Recent studies have shown a significant association its complications with birth weight. The aim our study was to analyze effect weight on occurrence metabolic disorders normal obese women.The group included 134 females average age 41.71 +/- 11.56 years. In these women relationship between anthropometric biochemical parameters, as well blood pressure values analyzed.Our results show...