A5021920570- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Cell Adhesion Molecules Research
- Neurotransmitter Receptor Influence on Behavior
- Signaling Pathways in Disease
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Biochemical and Structural Characterization
- Pancreatic function and diabetes
Center for Research and Advanced Studies of the National Polytechnic Institute
2022-2024
Instituto Politécnico Nacional
2022-2023
Abstract Latrophilin-3 (Lphn3; also known as ADGRL3) is a member of the adhesion G Protein Coupled Receptor subfamily, which participates in stabilization and maintenance neuronal networks by mediating intercellular through heterophilic interactions with transmembrane ligands. Polymorphisms modifying Lphn3 gene are associated attention-deficit/hyperactivity disorder (ADHD) children its persistence into adulthood. How these genetic alterations affect receptor function remains unknown. Here,...
Adhesion G protein-coupled receptors (aGPCRs) possess a unique topology, including the presence of GPCR proteolysis site (GPS), which, upon autoproteolysis, generates two functionally distinct fragments that remain non-covalently associated at plasma membrane. A proposed activation mechanism for aGPCRs involves exposure tethered agonist, which depends on cleavage GPS. However, this hypothesis has been challenged by observation non-cleavable exhibit constitutive activity, thus making function...
ABSTRACT Comorbidity between psychiatric traits is thought to involve overlapping pleiotropic effects from sets of genes. Notably, substance abuse a shared comorbid condition among various neurodevelopmental disorders with externalizing symptoms such as autism spectrum disorder and attention-deficit hyperactivity disorder, thus hinting at the nucleus accumbens (NAc) site for predisposition underlying convergence genetic influences in reward-related comorbidity. Here, we identify...
Adhesion G protein-coupled receptors (aGPCRs) possess a unique topology including the presence of GPCR proteolysis site (GPS) which upon autoproteolysis generates two functionally distinct fragments that remain non-covalently associated at plasma membrane. A proposed activation mechanism for aGPCRs involves release tethered agonist depends on cleavage GPS. However, this hypothesis has been challenged by observation non-cleavable exhibit constitutive activity, thus making function GPS widely...