Abstract Motivation A microRNA (miRNA) is a type of non-coding RNA, which plays important roles in many biological processes. Lots studies have shown that miRNAs are implicated human diseases, indicating might be potential biomarkers for various types diseases. Therefore, it to reveal the relationships between and diseases/phenotypes. Results We propose novel learning-based framework, MDA-CNN, miRNA-disease association identification. The model first captures interaction features diseases...

Gene Ontology (GO) is one of the most popular bioinformatics resources. In past decade, Ontology-based gene semantic similarity has been effectively used to model gene-to-gene interactions in multiple research areas. However, existing approaches rely only on GO annotations and structure, or incorporate local co-functional network. This may lead inaccurate GO-based resulting from incomplete topology structure annotations.We present NETSIM2, a new network-based method that allows researchers...

The Gene Ontology (GO) is a community-based bioinformatics resource that employs ontologies to represent biological knowledge and describes information about gene product function. GO includes three independent categories: molecular function, process cellular component. For better reasoning, identifying the relationships between terms in different categories are important. However, existing measurements calculate similarity either developed by using data only or take part of combined...

Recently, measuring phenotype similarity began to play an important role in disease diagnosis. Researchers have begun pay attention develop measurement. However, existing methods ignore the interactions between phenotype-associated proteins, which may lead inaccurate similarity. We proposed a network-based method PhenoNet calculate phenotypes. localized phenotypes network and calculated modules by modeling both inter- intra-similarity. was evaluated on two independent evaluation datasets:...

The coupling characteristics of the aerodynamic and thermal effects a surface dielectric barrier discharge plasma actuator its transfer in different boundary-layer flows are studied experimentally. is attached to flat-plate airfoil driving by an alternative-current signal. Different achieved wind tunnel adjusting airfoil's angle attack with Reynolds number 2.02 × 105. spatial temperature-rise distributions velocity fields induced actuation quiescent air show that influence range temperature...

A pair of surface mounted dielectric-barrier-discharge (DBD) plasma actuators is placed diametrically on a circular cylinder model. The flow field generated by the in steady and duty-cycle actuation modes measured particle image velocimetry. Salient features vortices are discovered for with frequency ranging from 5 to 1000 Hz ratio 0.01 0.99. results compared those continuous actuation. For given ratio, discrete vortex each DBD actuator an cycle low frequencies. Such created alternately side...

Abstract Motivation A microRNA (miRNA) is a type of non-coding RNA, which plays important roles in many biological processes. Lots studies have shown that miRNAs are implicated human diseases, indicating might be potential biomarkers for various types diseases. Therefore, it to reveal the relationships between and diseases/phenotypes. Results We propose novel learning-based framework, MDA-CNN, miRNA-disease association identification. The model first captures richer interaction features...

The Human Phenotype Ontology (HPO) is one of the most popular bioinformatics resources. Recently, HPO-based phenotype semantic similarity has been effectively applied to model patient data. However, existing tools are revised based on Gene (GO)-based term similarity. design models not optimized for unique features HPO. In addition, only allow HPO terms as input and provide pure text-based outputs.We present PhenoSimWeb, a web application that allows researchers measure similarities using...

A NACA0025 coflow jet airfoil model, including the inner and outer airfoils, was designed manufactured through 3D printing technology. Using duct connecting leading- trailing-edge slots formed by eight plasma actuators are arranged in synchronously driven two high-voltage alternating-current sources to realize (PCFJ) flow control technique. The test angle of attack range is 8–30°, Reynolds number 68,000. induced airflow characteristics were studied, mechanism PCFJ explored using detailed...

As one of the key components solid rocket motors (SRMs) and launch vehicles (LVs), deformation damage composite motor case (CRMC) can directly affect effectiveness SRMs. Therefore, it is particularly important to analyze failure cases. analysis remains complex due different modes composites at scales, this paper applies multiscale methods CRMC damage. A mechanical model established, data transfer between microscale, mesoscale, macroscale models achieved using submodel techniques. In paper,...

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Recently, measuring phenotype similarity began to play an important role in disease diagnosis. Researchers have begun pay attention develop measurement. However, existing methods ignore the interactions between phenotype-associated proteins, which may lead inaccurate similarity. We proposed a network-based method PhenoNet calculate phenotypes. localized phenotypes network and calculated modules by modeling both inter- intra-similarity. was evaluated on two independent evaluation datasets:...

Abstract The significance of the mechanical properties solid propellant during curing process lies in their contribution to stress‐strain calculations viscoelastic engineering materials and analysis structural integrity rocket motor charges. In order study Constitutive equation nitrate ester plasticized polyether (NEPE) process, indentation creep tests were carried out on NEPE propellant, constitutive model with reaction at 50 °C atmospheric pressure was studied. Firstly, based theory,...

Surface Dielectric Barrier Discharge (SDBD) plasma actuators driven by alternating current (AC), also known as AC-SDBD, have been used recently in many aerodynamic and heat transfer applications. The present study investigates experimentally the thermal effects of AC-SDBD actuator presence an external flow i.e. wind tunnel. oil visualization infrared thermography is performed to determine different boundary layer regions over model properties placed on upper surface, respectively. tunnel...

To establish a stable HEK293T cell line with c.392G>T (p.131G>V) mutation site knockout in

View Video Presentation: https://doi.org/10.2514/6.2022-3875.vid The new concept of the anti-/de-icing method based on Alternative-Current high voltage-driven surface dielectric barrier discharge (AC-SDBD) plasma actuation has no complicated mechanical structure and potential aerodynamic loss, making it to be anti- de-icing methods used by next-generation aircraft. AC-SDBD will produce thermal, aerodynamic, chemical electromagnetic effects, etc. Existing studies have shown that coupling...

View Video Presentation: https://doi.org/10.2514/6.2023-4434.vid The anti-/de-icing method based on Surface Dielectric Barrier Discharge plasma actuation driven by AC high-voltage signal has no complex mechanical structure and potential aerodynamic loss, which makes it a for the next generation of aircraft. existing research shows that coupling multiple physical fields causes effect supercooled water droplets. Meanwhile, this occurs in different time scales, is challenging its research. In...

View Video Presentation: https://doi.org/10.2514/6.2023-3777.vid Alternative-Current high voltage-driven surface dielectric barrier discharge (AC-SDBD) plasma actuation is a new concept of the anti-/de-icing method with no complicated mechanical structure and potential aerodynamic loss, which makes it to be anti- de-icing methods used by next-generation aircraft. AC-SDBD has not only effects, but also thermal, chemical electromagnetic etc. Many studies have shown that coupling...

Detailed two-dimensional particle image velocimetry (2D-PIV) is presented to study the vortex flow behind a cylindrical model with plasma control. A pair of alternating-current surface-dielectric-barrier-discharge (AC-SDBD) actuators symmetrically placed at azimuth angles ±90 degrees on surface. The asymmetric near cylinder visualized and measured steady unsteady actuation respectively in an open-test section return-circuit low-speed wind tunnel. incoming 5 m/s Reynolds number based diameter...

Flow control based on AC-SDBD plasma actuators has been widely used in various research regions of aerodynamics. However, the drawback flow is low efficiency energy conversion. It means induced aerodynamic effect only consumes a small part total electrical power, and large converted into heat with an obvious thermal effect, which often ignored by researchers. Our team proposed concept icing recent years engage new study: coupling effects effects. In this study, transfer characteristics...

When an aircraft flies through icy cloud at a low altitude and with speed, the surface of its windward parts will freeze due to impact supercooled water droplets in cloud. key aerodynamic parts, including leading-edge wings propeller blades, other are frozen, it seriously affect shape result drag increase lift reduction. It also controllability stability cause serious safety accidents. Therefore, icing phenomenon airplanes flight corresponding mechanism have always been focus attention by...

View Video Presentation: https://doi.org/10.2514/6.2022-3850.vid A circular cylinder using Plasma Co-Flow Jet (PCFJ) flow control technique was designed and manufactured through 3D printing technology. pair of PCFJ actuators are symmetrically distributed at ±90° azimuth angles. One actuator includes 4 long strips plasma to achieve the blowing suction effects realize co-flow jet technique. The near-field vortices were visualized a detailed particle-image-velocimetry (PIV) spatial dynamic...