ABSTRACT These data describe the distribution of risk factors for liver disease in Leeds, a large city UK. Anonymised, unlinked were aggregated to lower super output areas by Leeds GP extraction programme deprivation, obesity, diabetes and alcohol use. Incident was quantified from coding hospital admissions. Alcohol use, deprivation obesity associated with LD. Risk clustered together geographically. Liver blood tests more frequently done low‐disease prevalence. results illustrate health...

Biomimetic proteoglycans (BPGs) have the potential to treat osteoarthritis (OA) given that these molecules mimic structure and properties of natural proteoglycans, which are significantly reduced in OA. We examined effects BPGs injected into intra-articular space an vivo OA rabbit knee model evaluated effect on histological response, joint friction, BPG distribution retention. Rabbits underwent ACL transection create arthritic state after 5 weeks. rabbits were treated with or Euflexxa®...

Level-1 diagnostic study.The purpose of this study was to evaluate the sensitivity and specificity combined motor sensory intraoperative neuromonitoring (IONM) for cervical spondylotic myelopathy (CSM).Intraoperative during spine surgery began with modalities goal reducing neurological complications. Motor monitoring later added purported further increase when used in concert monitoring. Debate continues, however, as whether reliably detects reversible neurologic changes or simply adds...

Abstract Background The National Early Warning Score-2 (NEWS-2) is used to detect patient deterioration in UK hospitals but fails take account of the detailed granularity or temporal trends clinical observations. We data-driven methods develop dynamic early warning scores (DEWS) address these deficiencies, and tested their accuracy patients with respiratory disease for predicting (1) death intensive care unit admission, occurring within 24 h (D/ICU), (2) clinically significant requiring...

Rapid recovery protocols (RRPs) for total joint arthroplasty (TJA) can reduce hospital length of stay (LOS) and improve patient care in select cohorts; however, there is limited literature regarding their utility marginalized populations. This report aimed to evaluate the outcomes an institutional RRP TJA at a safety net hospital.A retrospective review 573 primary patients was done, comparing standard protocol (n = 294) cohorts 279). Measured included LOS, 90-day complications, revision...

High-percentage outpatient total joint arthroplasty (TJA) performed in a safety net hospital system has not been described. A rapid recovery protocol (RRP) was instituted at our that allowed eventual transition to TJA.Retrospective review of all primary knee and hip by single surgeon (RR) using an RRP performed. The initial cohort patients monitored overnight with the goal next-day discharge (n = 57), as evolved, subsequent had possibility same-day (PSDD, n 61). Outcome measures included...

Bone deficiencies in dysplastic acetabula create technical difficulties during total hip arthroplasty (THA). Bulk femoral head autograft (FHA) is one method to increase cup coverage and bone stock of the true acetabulum; however, only limited data exist on its efficacy through a direct anterior approach (DAA). This study aimed evaluate outcomes FHA THA via DAA hips.Retrospective review 34 patients (41 hips) with dysplasia (Crowe I-III) who underwent primary at single institution was...

Introduction: The time spent applying and interviewing for an orthopaedic fellowship has notable financial, educational, workflow consequences on both residents their respective residency programs. purpose of this study was to assess the perceptions regarding interview process suggest changes that could be implemented. Methods: Mixed-response questionnaires were sent surgery program directors (PDs) PGY-4 PGY-6 at 164 accredited allopathic programs in United States (August 2017). Results:...

This study aimed to evaluate whether an enhanced recovery protocol (ERP) for arthroplasty established during the COVID-19 pandemic at a safety net hospital can be associated with decrease in length of stay (LOS) and increase same-day discharges (SDDs) without increasing acute adverse events.

The use of machine learning methods for the prediction reaction yield is an emerging area. We demonstrate applicability support vector regression (SVR) predicting yields, using combinatorial data. Molecular descriptors used in tasks related to chemical reac?tivity have often been based on time-consuming, computationally demanding quantum calculations, usually density functional theory. Structure-based (molecular fingerprints and molecular graphs) are quicker easier calculate, applicable any...

Total femur replacement is a well-recognized salvage procedure and an alternative to hip disarticulation in patients with massive femoral bone loss. Compared conventional total replacement, intramedullary (IMTF) requires less soft tissue dissection preserves stock soft-tissue attachments. Despite these advantages, can still anticipate compromised functional outcomes high complication rates following IMTF. Prior studies describe IMTF the patient positioned laterally utilizing posterior or...

1University of Utah, Salt Lake City, Utah Disclosure: The Disclosure Potential Conflicts Interest forms are provided with the online version article (https://links.lww.com/JBJS/H935).

BACKGROUND Hip resurfacing arthroplasty (HRA) is an alternative to total hip (THA) that typically reserved for young active patients because it preserves bone. However, the benefits of HRA only hold true if conversion THA after failed provides acceptable outcomes. AIM To compare patient reported outcomes failure primary THA. METHODS A retrospective review 36 (37 hips) underwent between October 2006 and May 2019 by a single surgeon was performed. Patient [modified Harris Score (mHHS),...

Any means of reducing blood loss during total hip replacement is beneficial. Following femoral neck osteotomy, the cut end usually left. This a potential source significant low pressure ooze, which can account for sizeable proportion intraoperative and may also obscure surgical field. Cheap easily available bone wax, first described in 1892, be smeared across trabecular surface following osteotomy (Fig 1). The wax later removed on broaching femur. simple cost effective method limit bleeding...

A 26-year-old man presented after an automobile versus pedestrian accident with a Type IIIA open femur fracture complicated by necrotizing soft-tissue infection (NSTI) significant bone loss. Multiple limb-preserving operations failed, including the placement of plate-assisted, motorized lengthening intramedullary nail chimeric free flap. We describe patient's successful definitive treatment Van Nes rotationplasty (VNR). The patient currently ambulates independently prosthesis and is without...

Vitamin D deficiency may be a potentially modifiable risk factor in patients with orthopaedic conditions including Charcot arthropathy. The purpose of this study was to determine the prevalence vitamin and insufficiency arthropathy.All arthropathy seen our foot ankle surgery clinic from January 2017 through June 2021 were screened for serum 25-hydroxyvitamin levels. Patients categorized as sufficient, insufficient, or deficient based on previously accepted guidelines. calculated.A total 57...

<h3>Introduction</h3> Liver-related deaths are increasingly common in the UK and particularly frequent amongst people of working age. Understanding risk factors for liver disease their distribution is necessary to allow targeted public health hepatology interventions improve health. We aimed describe population-level current practice regarding testing a large city. <h3>Methods</h3> Leeds city approximately 900,000 England with single hospital provider, which also provides laboratory services...