A5073973049- Nutrition and Health in Aging
- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
- Monoclonal and Polyclonal Antibodies Research
- Clinical Nutrition and Gastroenterology
- Frailty in Older Adults
- Biofuel production and bioconversion
- Protein purification and stability
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Enzyme Production and Characterization
- Respiratory Support and Mechanisms
- Machine Learning in Healthcare
- Viral Infectious Diseases and Gene Expression in Insects
- Health Promotion and Cardiovascular Prevention
- Enzyme Structure and Function
- Animal Behavior and Welfare Studies
- Healthcare Technology and Patient Monitoring
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Body Composition Measurement Techniques
- Cardiac Arrest and Resuscitation
- Glycosylation and Glycoproteins Research
- Hydrology and Drought Analysis
- Patient Safety and Medication Errors
- Plant Gene Expression Analysis
Austrian Academy of Sciences
2024
Nottingham University Hospitals NHS Trust
2020-2022
University of Nottingham
2016-2022
Nottingham Biomedical Research Centre
2022
Respiratory Clinical Trials
2018
NIHR Clinical Research Network
2018
Nottingham City Hospital
2017
University of Sheffield
2006-2012
Northern General Hospital
2006-2007
Leibniz Institute of Plant Genetics and Crop Plant Research
1996
Abstract Well‐defined basement membrane laminin was seen in 98/158 (62%) rectal adenocarcinomas stained by an immunoperoxidase method. Only 27 (28%) patients with laminin‐positive tumours developed distant metastases, compared 39 (65%) laminin‐negative carcinomas. The corrected 5‐year survival rates for and were 65% 23%, respectively. Twenty‐five out of 30 (83%) well‐differentiated only 3/15 (17%) poorly differentiated contained laminin, moderately carcinomas showing intermediate status...
Using high-performance liquid chromatography and nuclear magnetic resonance we identified vicianin as the cyanogenic compound of Phlebodium aureum. The (R)-hydroxynitrile lyase involved during cyanogenesis in catabolism aglycon ([R]-mandelonitrile) was purified to apparent homogeneity. holoenzyme is a homomultimer with subunits Mr = 20,000. At least three isoforms enzyme exist. In contrast other hydroxynitrile lyases, mandelonitrile (MDL) from P. aureum not inhibited by sulfhydryl- or...
To test the effect of nutritional support on older patient's quality life.Double-blind, randomized, placebo-controlled trial conducted from March 2001 to January 2004.United Kingdom.Two hundred twenty-five hospitalized acutely ill patients.Normal hospital diet plus 400-mL oral supplements daily for 6 weeks. The composition supplement was such as provide 995 kcal energy and 100% Reference Nutrient Intakes a healthy person vitamins minerals.Baseline, 6-week, 6-month status life.Randomization...
Protein disulphide-isomerase activity was determined in homogenates of chick-embryo tissues. Activities were highest tissues active procollagen synthesis and maximal at the developmental stage synthesis. These variations protein correlate closely with those previously observed for protocollagen hydroxylase activities.
Abstract Objective To measure energy expenditure of acutely ill elderly patients in hospital and following discharge the community. Design Sixty-three consecutive hospitalised were recruited. Eight studied to assess reliability Delta Tract Machine as a expenditure; 35 had their on two occasions 20 measured at 6 weeks community Results Men higher basal (BMR) values compared women however difference was not statistically significant [Men, mean (SD) 1405 (321) Kcal, 1238 (322) kcal; (95% CI)...
Four hundred and forty-five randomly selected hospitalised patients had their nutritional status assessed from anthropometric, haematological biochemical data. Nutritional was compared between survivors non-survivors at baseline, 6 weeks months. Using Cox's proportional hazard analysis, we measured the association assessment variables 1-year mortality after adjusting for disability, chronic illness, medications, smoking tissue inflammation. significantly worse amongst with survivors, showed...
Objective: To investigate the validity of a patient kept food diary in relation to weighted intakes and measure dietary older people both hospital after discharge at home.Design: A randomly selected cohort hospitalised elderly patients was recruited. All were instructed how keep record all drink consumed any leftovers. Food diaries for up seven days community. In 18 consecutive records compared with weighed intake.Setting: Associate Teaching Hospital, United Kingdom.Results: total 116...
This report presents the results of a survey conducted between February and April 1988 to ascertain Ugandans' perception AIDS as problem, their knowledge disease how it is spread, resultant change in sexual behaviour of, attitudes towards, condoms. Two hundred four people (98 women, 106 men) were interviewed from three locations; Kampala (an area with high incidence AIDS), Kabale, town central Kigezi, villages North Kigezi (both relatively low areas). The main points emerge are: (1) all...
Abstract Background The National Early Warning Score-2 (NEWS-2) is used to detect patient deterioration in UK hospitals but fails take account of the detailed granularity or temporal trends clinical observations. We data-driven methods develop dynamic early warning scores (DEWS) address these deficiencies, and tested their accuracy patients with respiratory disease for predicting (1) death intensive care unit admission, occurring within 24 h (D/ICU), (2) clinically significant requiring...
Early Warning Scores (EWSs) are used to monitor patients for signs of imminent deterioration. Although in respiratory disease, EWSs have not been well studied this population, despite the underlying cardiopulmonary pathophysiology often present. We examined performance two scoring systems with disease.Retrospective cohort analysis vital observations all admitted a unit over 2-year period. were linked outcome data establish National EWS (NEWS) compared results locally adapted EWS.Nottingham...
Although a number of studies have reported raised total plasma homocysteine (tHcy) concentrations in free-living older people, there are no data on response to mixed nutrient supplement patients. A concentration patients is partly reflection their co-morbidity, including impaired renal function, and uncertainty about the extent which dietary interventions can improve tHcy.To determine tHcy supplements during acute illness.Two-hundred thirty-six hospitalized, acutely ill patients, who were...
Objectives To describe the inpatient population, establish patterns in admission and mortality over a 4-year period different cohorts assess prognostic ability workload implications of introducing National Early Warning Score 2 (NEWS2) associated escalation protocol. Design Retrospective cohort analyses medical surgical admissions. Setting Large teaching hospital with tertiary care major trauma centre employing an electronic observations platform, initially local early warning score,...
Oxygen is the most commonly used drug in acute hospital setting. can be lifesaving but there increasing evidence that it cause harm if not given correctly. Prescription of oxygen, according to target saturations, has been advocated since 2008 compliance remains at low levels. This paper describes a novel approach improve oxygen prescription and titration three trusts using colour-coded silicone wristband. The project ran for 3 months covered more than 2,000 emergency admissions hospital....
<h3>ABSTRACT</h3> <h3>Aims</h3> Accurately predicting risk of patient deterioration is vital. Altered physiology in chronic disease affects the prognostic ability vital signs based early warning score systems. We aimed to assess potential patterns improve outcome prediction patients with respiratory disease. <h3>Methods</h3> Patients admitted under medicine between April 2015 and March 2017 had their National Early Warning Score 2 (NEWS2) calculated retrospectively from sign observations....
This study examines the link between media trust and consumers’ willingness to pay (WTP) for online news in post-pandemic era. A 2023 survey of 1000 Austrian participants investigated how affects WTP identified key predictors moderators. Findings reveal a strong correlation both expenditure (ME), highlighting trust’s critical role organizations’ financial sustainability, as consumers favor credible trusted brands. Accordingly, companies must develop comprehensive strategy (re)build trust,...
(S)-p-Hydroxy-mandelonitrile lyase from Sorghum bicolor has been crystallized in three different forms using the hanging-drop vapor-diffusion technique. Crystal form I is obtained 1.4 M (NH(4))(2)SO(4) 100 mM Na-acetate, pH 4.6, and belongs to orthorhombic space group P2(1)2(1)2(1). The cell dimensions are a = 71.4, b 95.8, c 149.1 A. A complete set of diffraction data collected 2.6 resolution. Form II crystals grown 500 Li(2)SO(4) 13% polyethylene glycol 8000. These appear as hexagonal...