A5060479111- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Melanoma and MAPK Pathways
- Pancreatic and Hepatic Oncology Research
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Cytokine Signaling Pathways and Interactions
Regione Campania
2022
Microsatellite instability (MSI) is a predictive biomarker for immune checkpoint inhibitors. The main goal was to investigate the discordance between IHC and PCR/NGS MSI testing in gastrointestinal cancers.Two series were analyzed through mismatch-repair-system proteins (MMRP) PCR, with one of 444 colorectal cancers (CRC) other 176 gastric (GC). All cases discordant results PCR by NGS. staining evaluated as follows: proficient MMR (pMMR), all positive; deficient (dMMR), loss heterodimer;...
Background We previously reported rare regressive genetic trajectories of KRAS pathogenic mutations as a specific hallmark the genuine oligometastatic status in colorectal cancer (CRC). Methods Survival and prognostic impact disease extent 140 metastatic CRC patients were evaluated through Kaplan–Meyer curves Log-Rank test. assessed Illumina NovaSeq 6000 platform TruSight™ Oncology 500 kit. HLA typing was carried out by PCR with sequence-specific oligonucleotides. Lymphocyte densities tumors...
We studied the predictive and prognostic influences of hypertension (HT), type 2 diabetes (T2D), weight, p53 mutations in metastatic colorectal cancer (CRC) patients.T2D was diagnosed according to ADA criteria. HT classified ACC/AHA guidelines. BMI (body-mass index) calculated WHO TruSigt™Oncology 500 kit applied construct genomic libraries for Next Generation Sequencing (NGS) analysis. The Illumina NovaSeq 6000 technological platform TruSight Oncology bioinformatics pipeline were analyze...
Abstract Background TAS-102 (Lonsurf ® ) is an oral fluoropyrimidine consisting of a combination trifluridine (a thymidine analog) and tipiracil phosphorylation inhibitor). The drug effective in metastatic colorectal cancer (mCRC) patients refractory to fluorouracil, irinotecan oxaliplatin. This study real-world analysis, investigating the interplay genotype/phenotype relation sensitivity. Methods Forty-seven consecutive mCRC were treated with at National Cancer Institute Naples from March...
We previously described three patients affected by metastatic colorectal cancer (mCRC) who experienced spontaneous tumour shrinkage during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Thereafter, the were closely monitored and no systemic treatments applied. Here, we report follow-up clinical information about these as well genetic characterization of their primary tumours through TruSigt™Oncology 500 Next Generation Sequencing test targeting 523 cancer-relevant...
Oligo-metastatic disease (OMD) in the field of oncology denotes a distinct subset metastatic tumors characterized by less aggressive biological behavior and extended survival times comparison to their widely counterparts. While there is general consensus regarding existence OMD, remains lack accepted criteria for its priori identification at time presentation. This review delves into concept placing particular emphasis on significance understanding limitations potential genetic assessments....