Despite the significant progress in fields of biology, physiology, molecular medicine, and pharmacology; designation properties nitrogen monoxide regulation life-supporting functions organism; numerous works devoted to this molecule, there are still many open questions field. It is widely accepted that nitric oxide (•NO) a unique molecule that, despite its extremely simple structure, has wide range body, including cardiovascular system, central nervous system (CNS), reproduction, endocrine...

Prenatal hypoxia (PH) is a key factor in the development of long-term cardiovascular disorders, which are caused by various mechanisms endothelial dysfunction (ED), including those associated with NO deficiency. This emphasizes potential therapeutic agents modulator properties, such as Thiotriazoline, Angiolin, Mildronate, and L-arginine, treatment PH. Methods: Pregnant female rats were given daily intraperitoneal dose 50 mg/kg sodium nitrite starting on 16th day pregnancy. A control group...

Prenatal hypoxia (PH) disrupts fetal heart development and induces persistent cardiovascular dysfunction in offspring. The nitric oxide (NO) system is pivotal regulating myocardial function, influencing vascular tone, contractility, endothelial integrity during development. PH alters NO signaling, leading to dysfunction, mitochondrial damage, oxidative stress, which exacerbate impairment increase cardiomyocyte apoptosis. Elevated nitrosative through excessive reactive nitrogen species,...

Diabetes mellitus is one of the important independent risk factors for development neurological disorders such as ischemic stroke, transient attacks, vascular dementia and neurodegenerative processes. Hyperglycemia plays a crucial role trigger in pathogenesis these disorders. In this review, we summarize existing data on molecular mechanisms diabetic encephalopathy development, consider features oxidative nitrosative stresses, changes thiol-disulfide system, well mitochondrial endothelial...

For the first time to optimize creation of new neuroprotective agents based on bioflavonoids, we applied information technologies - docking analysis calculate binding candidate molecules pharmacological target protein transthyretin, as well program virtual screening NO scavengers. As a result this approach, substance catechin was isolated from quercetin, catechin, Epicatechin gallate, Epicatechin, Procyanidin B1, B2, B3, Catechin-3-gallate according analysis. screening, identified potential...

Intrauterine hypoxia in newborns leads to a multifaceted array of alterations that exert detrimental impact on the cardiovascular system. The aim this research was assess cardioprotective effects modulators nitric oxide (NO) system, including L-arginine, Thiotriazoline, Angiolin, and Mildronate, during early postnatal period following intrauterine hypoxia. Methods: study involved 50 female white rats. Pregnant rats were given daily intraperitoneal dose mg/kg sodium nitrite starting 16th day...

Introduction : This study was designed to evaluate the effect activity of RAIL-gel in comparison with Citicoline on nitroxydergic system during acute cerebrovascular accident. Methods In this study, 80 white nonlinear rats were randomly assigned 4 groups (20 each): 1) intact; 2) control - untreated accident (ACVA), examined th day; 3) animals ACVA, receiving RAIL, 18 4) treated Citicoline, day. The expression inducible NOS determined by Western blotting. nitrosative stress marker,...

COVID-19 leads to disruption of the blood coagulation system, thrombosis, hypercoagulability, as a result, an increased risk strokes and heart attacks. During COVID-19, endothelial dysfunction develops associated with NO deficiency decrease in level SH compounds. Tiazotic acid (Thiotriazoline) has immunomodulatory, anti-inflammatory, antioxidant, anti-ischemic, cardio- endothelioprotective, antiplatelet, hepatoprotective activity. Our studies conducted at National Research Medical Center...

Keywords: endothelial dysfunction, NO, nitrosative stress, reduced thiols, S-derivatives of 1,2,4-triazole

Background. Posthypoxic cardiopathy is one of the risk factors for development cardiovascular pathology (rhythm disturbances, vascular dystonia, etc.) in subsequent age periods and requires treatment approaches. Objective. to evaluate cardioprotective effect modulators NO system by on ECG rats after intrauterine hypoxia. Methods. Modeling prenatal hypoxia (PH) daily intraperitoneal administration sodium nitrite solution pregnant female white weighing 220–240 g, aged 4.5 months, from 16th...

The regulation of cell death is a fundamental issue in biology and continues to be intensely investigated worldwide. significance research this field persists because understanding the determinants lifespan directly impacts maintenance multicellular organism homeostasis and, consequently, crucial for addressing biomedical challenges associated with various diseases. It recognized that initiation can prompted by both specific signals (such as cytokines or hormones) nonspecific stimuli,...

For the first time, to optimize creation of new neuroprotective agents based on bioflavonoids, we applied information technologies; these include docking analysis calculate binding candidate molecules pharmacological target protein transthyretin as well a program virtual screening NO scavengers. As result this approach, substance catechin was isolated from molecules—quercetin, catechin, Epicatechin gallate, Epicatechin, Procyanidin B1, B2, B3, and Catechin-3-gallate—according analysis....

Prenatal hypoxia plays a crucial role in programming long-term cardiovascular dysfunction through mechanisms like endothelial and nitric oxide system impairment, highlighting the potential of therapeutic agents, such as thiotriazoline, angiolin, mildronate, L-arginine, for mitigating these adverse effects. Methods. Levels sEPCR, Tie2 tyrosine kinase, VEGF-B, SOD1/Cu-Zn SOD, GPX4, GPX1 were measured heart's cytosolic homogenate using ELISA. Results. Modeling prenatal (PH) resulted...

Introduction: Experimental autoimmune (allergic) encephalomyelitis (EAE) induced by intradermal injection of ho­mogenate the brain, spinal cord and peripheral nerve with Freund’s stimulator, refers to a true disease nervous system.
 Materials methods: studies were conducted on white nonlinear rats. To induce experimental aller­gic (EAE), homologous brain homogenates was used, which leads among other drugs (homologous, heterogeneous homogenates) encephalitogenity. The connective tissue...

Selenium is an essential component of more than two dozen enzymes and other selenoproteins that play critical roles in reproduction, DNA synthesis, thyroid hormone metabolism, protection from oxidative damage infection. has a protective action against some forms cancer cardiovascular diseases, modulates levels inflammatory mediators, promotes to maintain bone homeostasis protects loss. significance as cardioprotective agent may be associated not only with its antioxidant properties, but also...

The aim of this research was to analyze the neuroprotective action drugs via an evidence-based approach analyzing expression endogenous neuroprotection factors in various experimental models cerebral ischemia Wistar white rats (intracerebral hemorrhage, carotid artery occlusion, prenatal hypoxia) further substantiate their use treatment CNS damage. studies were carried out accordance with "Regulations on Use Animals Biomedical Research" and European Convention Protection Used for Scientific...

The problem of pharmacologically correcting CNS hypoxic disorders is one priority. HSP70, an endogenous regulator cytoprotective processes, can be considered as effective pharmacological target. aim this research was to study the ability cerebrocurin, angiolin, glutoredoxin, tamoxifen, thiotriazoline, L-arginine, nikomex, HSF-1 and piracetam modulate level HSP70 in cerebral cortex blood plasma rats after prenatal hypoxia (PH). We studied effect drugs on content neurons (cytoplasmic...

Abstract : In the complex treatment of chronic heart failure (CHF) β-adrenoblockers (carvedilol, nebivolol, bisoprolol, metoprolol) are used, which due to their pharmacological properties increase survival rate patients, improve cardio- and haemodynamic parameters, metabolism. However, modern realities in medicine require creation new more effective safe β-adrenoblockers. this regard, potential drug Hypertirl is interest. The aim was evaluate cardioprotective effect...

The study of mitochondrial dysfunction has become increasingly pivotal in elucidating the pathophysiology various cerebral pathologies, particularly neurodegenerative disorders. Mitochondria are essential for cellular energy metabolism, regulation reactive oxygen species (ROS), calcium homeostasis, and execution apoptotic processes. Disruptions function, driven by factors such as oxidative stress, excitotoxicity, altered ion balance, lead to neuronal death contribute cognitive impairments...

first_page Download PDF settings Order Article Reprints Font Type: Arial Georgia Verdana Size: Aa Line Spacing:  Column Width:  Background: Open AccessAbstract HIF-1α as a Potential Target for Pharmacologic Correction after Prenatal Hypoxia † by Olena Gennadiivna AliyevaOlena Aliyeva SciProfiles Scilit Preprints.org Google Scholar 1,*, Igor Fedorovich BelenichevIgor Belenichev 2 and Olexandrivna PopazovaOlena Popazova 1 Department of Pharmacology Medical Formulation with Course Normal...

β-adrenergic blockers have been actively used in the treatment of heart failure, which relieve excessive sympathetic stimulation myocardium, reduce calcium overload cardiomyocytes, heart's oxygen demand, inhibit lipid peroxidation and stabilize cell membranes, an antiarrhythmic effect. The aim: to compare efficiency various drugs with new potential "Hypertril" conditions modeling doxorubicin chronic failure (CHF) improve parameters. Objective: CHF was modeled on 85 white outbred rats...

Many children and adults who have suffered prenatal hypoxia at an early age develop many serious diseases. This disease is actual problem of pediatric cardiology little studied. The aim was to analyze the cardioprotective effect L-arginine, Thiotriazoline, Angioline Mildronate on cardiovascular system rats after hypoxia. Methods: experiments were carried out 50 female white rats; intraperitoneal sodium nitrite solution administered daily pregnant 16 days a dose mg/kg. Control received...