Abstract Background Recently, the development of an artificial oxygen carrier that can replace blood transfusions is gaining attention, particularly in response to war and COVID-19 pandemic. However, as yet, none existing hemoglobin-based carriers (HBOCs) perfluorocarbon-based (PFOCs) have been approved by United States Food Drug Administration (FDA) European Medicines Agency (EMA). Area covered Several difficulties are encountered during PFOCs. Here, we discuss possibility developing PFOCs...

Paclitaxel-loaded hyaluronan solid nanoemulsions for enhanced treatment efficacy in ovarian cancer Joo-Eun Kim, Young-Joon Park College of Pharmacy, Ajou University, Suwon City, Republic Korea Abstract: (PTX-HSNs) were successfully fabricated the delivery PTX to improve via active tumor targeting. PTX-HSNs using high-pressure homogenization with a microfluidizer and lyophilized d-mannitol. Hyaluronan was coated on outside PTX-HSN sphere. The mean size maintained less than 100 nm, relatively...

Paclitaxel (PTX) is a effectively chemotherapeutic agent which extensively able to treat the non-small cell lung, pancreatic, breast and other cancers. But it practically insoluble drug with water solubility less than 1 µg/mL, restricts its therapeutic application. To overcome problem, hyaluronic acid-complexed paclitaxel nanoemulsions (HPNs) were prepared by ionic complexation of acid (HA) specifically target lung cancer. HPNs composed DL-α-tocopheryl acetate, soybean oil, polysorbate 80,...

1 O 2 reacts with RMs but the effect of on function has been ambiguous. In this work we show functionality from various perspectives and classified them following reaction .

The aim of this study was to develop immediate-release oral rabeprazole sodium tablets with rapid efficacy and gastric stability for the treatment gastroesophageal reflux disease. Rabeprazole is a commonly prescribed proton pump inhibitor; however, it extremely unstable degrades in acidic environments. Hence, has been manufactured supplied only enteric-coated tablet form, while (IR) formulations drug are very limited. In study, we applied quality by design (QbD) approach formulate optimize...

This study aimed to develop a heat shock protein 90 (Hsp90) inhibitor liquisolid tablet with improved solubility overcome low bioavailability issues. As an active pharmaceutical ingredient (API), JIN-001, novel Hsp90 inhibitor, was reported have substantial in vitro antiproliferative and vivo antitumor activity; however, JIN-001 crystalline solid very aqueous solution, therefore, Capryol 90, which has excellent solubilization ability, selected as optimal liquid vehicle based on studies....

The purpose of this study is to derive an optimal drug release formulation with human clinical bioequivalence in developing a sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixed-dose combination (FDC) tablet as treatment for type 2 diabetes mellitus. As mellitus, the combined prescription dipeptidyl peptidase-4 (DPP-4) inhibitors and sodium-glucose cotransporter-2 (SGLT-2) common. Therefore, simplified number individual drugs taken improved compliance by FDC tablets...

A functional lab-on-a-chip has been developed for simultaneous quantitative analyses of high-density lipoprotein (HDL) cholesterol (HDL-C) and total (total-C) in a submicroliter plasma sample. The analytical device was fabricated by placing commercial membranes, traditionally used rapid diagnostics, within microfluidic channels engraved on the surface plastic chip. concentration HDL-C measured using enzymatic reactions to produce colorimetric signal after separation single from mixture. Two...

A quality-by-design approach was adopted to develop telmisartan potassium (TP) tablets, which were bioequivalent with the commercially available Micardis® (telmisartan free base) tablets. The dissolution pattern and impurity profile of TP tablets differed from those because base is poorly soluble in water. After identifying quality target product critical attributes (CQAs), drug dissolution, impurities predicted be risky CQAs. To determine exact range cause risks, we used risk assessment...

The aim of this study was to develop a single-layered version commercially available Twynstar® (Telmisartan + Amlodipine) double-layered tablets improve the dosing convenience. A quality-by-design approach applied version. To evaluate range and cause risks for tablet in formulation design research, we used tools risk assessment, initial assessment preliminary hazard analysis main failure mode effect determine parameters affecting formulation, drug dissolution, impurities. critical material...

Abstract Background Owing to the limited amount of research, there are no nanoparticle-based anticancer agents that use hydrophilic drugs. Therefore, we developed irinotecan-loaded self-agglomerating hyaluronan nanoparticles (ISHNs). While irinotecan has high hydrophilicity, resulting nanoparticle should possess drug-loading capacity and allow selective targeting cluster differentiation 44 (CD44) protein, which is overexpressed on surface tumor cells. Results The ISHNs were successfully made...

This study aims to examine the contribution of nanoporous silica entrapped lipid-drug complexes (NSCs) in improving solubility and bioavailability dutasteride (DUT). An NSC was loaded with DUT (dissolved lipids) dispersed at a nanoscale level using an entrapment technique. microemulsion formation confirmed ternary phase diagram, while presence lipid scanning electron microscopy. Differential calorimetry X-ray diffraction revealed amorphous properties NSC. The prepared all had excellent...

The purpose of this study was to develop a hydrolysis-resistant optimized oral formulation tenofovir disoproxil (TD) using stabilizer. To stabilized TD tablet bioequivalent the commercial fumarate (TDF, Viread®) tablet, free base prepared and its degradation profile stability were investigated. showed antiviral activity, but absorption limited in intestinal tract because premature degradation. drug subjected severe conditions for stress test catalyzed under neutral, basic, oxidative,...

We aimed to develop nafamostat mesylate immediate-release tablets for the treatment of COVID-19 through drug repositioning studies injection. Nafamostat is a serine protease inhibitor known inhibit activity transmembrane protease, 2 enzyme that affects penetration virus, thereby preventing binding angiotensin-converting receptor in vivo and spike protein virus. The formulation was selected stability study after manufacturing by wet granulation process direct tableting stable tablet....

To develop Quality by Design based drug, we compared and evaluated the self-made open source DoE R program Minitab ?? statistic program, which are used in of Experiments for reasonable experiments data reliability. An real-time accumulation was developed to enable a design experiment. Then, independent variables dependent wet granulation process telmisartan potassium tablets were performed experimental using two programs. After statistical programs executed, regression equations, analysis...

Tianeptine tablets are currently marketed to be designed for immediate-release tablets. The tianeptine has a short half-life, making it difficult design sustained-release and achieve bioequivalence with the tablet (Stablon®). We established in vitro-in vivo correlation (IVIVC) of three formulations according their granule size. To evaluate sustained drug release, vitro tests were performed pH 1.2 media 24 h. In pharmacokinetic analysis was following oral administration reference test beagle...

Background: Telmisartan and rosuvastatin calcium fixed-dose combination double-layer tablet is used for hypertension hyperlipidemia treatment. Owing to the critical problem in establishing specificity, precision, accuracy of USP analysis method simultaneous both components, an that could be applied researchers field urgently needed. Objective: To develop validate a reversed phase-high-performance liquid chromatography quantitative dissolution samples telmisartan tablets, as Methods: The...