A5049651989- Sperm and Testicular Function
- Animal Genetics and Reproduction
- Reproductive Biology and Fertility
- Mesenchymal stem cell research
- Nigella sativa pharmacological applications
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Pluripotent Stem Cells Research
- Ovarian function and disorders
- Electrospun Nanofibers in Biomedical Applications
- Sirtuins and Resveratrol in Medicine
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Nanoplatforms for cancer theranostics
- Chemotherapy-induced organ toxicity mitigation
- Phytoestrogen effects and research
- Medication Adherence and Compliance
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Antioxidant Activity and Oxidative Stress
- Chromium effects and bioremediation
- Connexins and lens biology
- Cancer-related gene regulation
Razi University
2015-2024
Ferdowsi University of Mashhad
2012-2016
Kermanshah University of Medical Sciences
2008
Some studies suggest that chronic low-grade inflammation is involved in insulin resistance polycystic ovary syndrome (PCOS). This study assessed possible involvement of alteration expression two pro-inflammatory factors, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) adipose tissues PCOS rats the impairment actions. Also, effects resveratrol as an anti-inflammatory agent were investigated.Fifteen female Wistar (21 days old) divided into three groups (n=5): I) Control, II)...
Identifying effective internal factors for regulating germline commitment during development and maintaining spermatogonial stem cells (SSCs) self‐renewal is important to understand the molecular basis of spermatogenesis process, develop new protocols production from other cell sources. Therefore, this study was designed investigate single‐cell RNA‐sequencing data identification differentially expressed genes (DEGs) in 12 mouse‐derived single SSCs (mSSCs) compare with 16 mesenchymal cells....
Abstract Bioremediation is the removal of heavy-metals such as nickel (Ni) using microorganisms and has been considered an important field in biotechnology. Isolation characterization exhibiting bioremediation activities their optimization to treat polluted wastewaters a vital difficult task remediation technologies. In this study, investigation was carried out isolate Ni (II) remediating microbial strains from soils contaminated with municipal solid waste leachate. Furthermore, Taguchi...
Background: In the field of human breast cancer, most recent researches referred to influence endogenous estrogen or exposure environmental estrogen, as risk factors. Zearalenone (ZEN) a mycotoxin and its derivative α- zearalenol (α-ZOL) are known nonsteroidal estrogenic compounds with potential endocrine disrupting properties. Objectives: The present study was designed investigate effects ZEN α-ZOL on cancer cell lines MCF-7 MDAMB-468. Materials Methods: Cell were treated by low high doses...
Purpose Gastrointestinal (GI) malignancies are among the 5 most common cancers in Iran, and their high associated mortality rates attributable to late diagnosis poor treatment options. SOX2, a transcription factor necessary for maintenance induction of pluripotency self-renewal, has been identified as lineage-survival oncogene several cancers. In present study, we examined SOX2 expression esophageal squamous cell carcinoma (ESCC), gastric adenocarcinoma colon (SCC), well normal GI tissues,...
Background: Placental growth factor is involved in human gastric cancer initiation and progression through stimulating the proliferation, angiogenesis, invasion metastasis of cancerous cells. Previous studies indicate that expression profiles hsa-miR-22-3p, hsa-let-7b-3p, hsa-miR-451b, hsa-mir-4290 change MKN-45- derived stem-like Therefore, this study aims to investigate effect PlGF knockdown on expressions MKN-45-derived cells.Methods: We used a non-adhesive culture system derive cells...
Cancer stem cells (CSCs), subpopulations of cancer cells, are responsible for tumor progression, metastasis, and relapse. Changes in amino acid metabolism linked to breast recurrence metastasis.This study aimed evaluate the changes profile MCF-7 MDA-MB-231 during spheroid formation discover specific metabolic properties CSCs.MCF-7 were cultured as spheroids evaluated characterize their CSC properties. The characteristics by examining expression markers conducting drug resistance assays. In...
Abstract Spermatogonial stem cells (SSCs), which are at the basis of spermatogenesis process, valuable with different applications in biotechnology and regenerative medicine. Understanding molecular SSC self‐renewal differentiation various developmental stages male organism is crucial to find key factors SSCs fate function. Therefore, this study was aimed use single‐cell RNA‐sequencing dataset analysis for identification differentially expressed genes (DEGs) their regulators 3 7 days old...