A5063757307- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Tendon Structure and Treatment
- Cardiac Valve Diseases and Treatments
- Orthopedic Surgery and Rehabilitation
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Nerve Injury and Rehabilitation
- Hernia repair and management
- Surgical Sutures and Adhesives
- Knee injuries and reconstruction techniques
- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Myofascial pain diagnosis and treatment
- Cardiovascular Syncope and Autonomic Disorders
- Medical research and treatments
- Trauma Management and Diagnosis
- Musculoskeletal pain and rehabilitation
- Total Knee Arthroplasty Outcomes
- Surgical Simulation and Training
- Pelvic and Acetabular Injuries
- Streptococcal Infections and Treatments
- Urological Disorders and Treatments
- Body Contouring and Surgery
- Nail Diseases and Treatments
Cleveland Clinic
2016-2025
Cleveland Clinic Lerner College of Medicine
2015-2024
Case Western Reserve University
2021-2023
Columbia University Irving Medical Center
2022
University of Michigan
1994-2001
Orthopaedic Research Laboratories
1994-2001
Evidence to justify the use of porcine small intestine submucosa augment repairs large and massive rotator cuff tears is based on favorable results found in studies Achilles tendon infraspinatus canines. The purpose this study was determine effectiveness a submucosal patch repair chronic two-tendon humans.Thirty shoulders with tear that completely repairable open surgery were randomized be treated either augmentation mucosa or no augmentation. All patients completed PENN shoulder-score...
Background: We are not aware of any in vitro study comparing the biomechanical, biochemical, and cellular properties commercial extracellular matrix materials marketed for rotator cuff tendon repair. In this study, GraftJacket, TissueMend, Restore, CuffPatch were quantified compared with each other. The elastic moduli also that normal canine infraspinatus tendon. Methods: Samples tested from different manufacturing lots four materials: GraftJacket (ten lots), TissueMend (six), Restore (ten),...
Despite advances in surgical treatment options, failure rates of rotator cuff repair have continued to range from 20% 90%. Hence, there is a need for new strategies that provide effective mechanical reinforcement as well stimulate and enhance the intrinsic healing potential patient. The purpose this study was evaluate extent which augmentation acute tendons with newly designed poly-L-lactide device would improve functional biomechanical outcomes canine model.Eight adult, male mongrel dogs...
Tendons have complex mechanical behaviors that are nonlinear and time dependent. It is widely held these provided by the tissue’s composition structure. generally thought type I collagen provides primary elastic strength to tendon while proteoglycans, such as decorin, play a role in failure viscoelastic properties. This study sought quantify structure-function relationships comparing properties between normal mice genetically engineered for altered content absence of decorin. Uniaxial...
Background: Long-standing tears of the rotator cuff can lead to substantial and perhaps irreversible changes in affected muscles. We developed a chronic tear canine model investigate quantify time-related passive mechanics, volume, fat infraspinatus muscle. hypothesized that muscle stiffness would increase, volume decrease, content increase at twelve weeks following tendon detachment. Methods: The right eight adult mongrel dogs were surgically detached from proximal part humerus. uninvolved...
Background: Ten to seventy percent of rotator cuff repairs form a recurrent defect after surgery. The relationship between retraction the repaired tendon and formation is not well defined. Purpose/Hypotheses: To measure prevalence, timing, magnitude repair correlate these outcomes with full-thickness on magnetic resonance imaging, as clinical outcomes. We hypothesized that (1) common phenomenon, although always associated defect; (2) correlates timing retraction; (3) outcome at 52 weeks...
Background: Anterior tears of the supraspinatus tendon are more likely to be clinically relevant than posterior supraspinatus. We hypothesized that anterior involving rotator cuff cable insertion associated with greater tear gapping, decreased stiffness, and increased regional strain under physiologic loading conditions compared equivalently sized crescent. Methods: Twelve human cadaveric shoulders were randomized undergo simulation either (n = 6) or adjacent crescent 6). For each specimen,...
These studies sought to investigate quantitative relationships between the complex composite structure and mechanical properties of tendon. The isolated mouse tail tendon fascicle was chosen as an appropriate model for these so-called “structure-function” investigations. Specifically, collagen fibril diameters were measured in fascicles from immature (3 week) control, adult (8 Mov13 transgenic mice. Results demonstrated a moderate correlation mean diameter stiffness (r = 0.73, p 0.001)...
Abstract The isolated mouse tail tendon fascicle, a functional and homogenous volume of extracellular matrix, was utilized as an experimental system to examine the structure–function relationships in tendon. Our previous work using this model demonstrated between mean collagen fibril diameter fascicle mechanical properties fascicles from three different groups mice (3‐week 8‐week control Mov13 transgenic) K.A. Derwin, L.J. Soslowsky, J. Biomech. Eng. 121 (1999) 598–604. These were chosen...
Background: Evidence to justify the use of porcine small intestine submucosa augment repairs large and massive rotator cuff tears is based on favorable results found in studies Achilles tendon infraspinatus canines. The purpose this study was determine effectiveness a submucosal patch repair chronic two-tendon humans. Methods: Thirty shoulders with tear that completely repairable open surgery were randomized be treated either augmentation mucosa or no augmentation. All patients completed...
Our long-term objective is to enhance tendon repair by delivering cells on natural biologic scaffolds the site. Clinical outcomes may be improved first preconditioning these cell-seeded constructs in bioreactors their properties at implantation and deliver expressing a desired phenotype. In this work, we have investigated effect of vitro mechanical conditioning small-intestine submucosa (SIS) seeded with primary (tenocytes). SIS (with without cells) were conditioned under various loading...
Oxygen is necessary for maintaining cell proliferation and viability extracellular matrix (ECM) production in 3-dimensional tissue engineering. Typically, diffusion the primary mode oxygen transport vitro; thus, ensuring an adequate supply essential. In this study, we determined coefficients of 3 natural ECMs that are being investigated as construct scaffolds tendon engineering: small-intestine submucosa (SIS), human dermis (Alloderm), canine fascia lata. Diffusion were using a standard...