A5083191247- Virus-based gene therapy research
- Cancer Research and Treatments
- AI in cancer detection
- 3D Printing in Biomedical Research
- Medical Image Segmentation Techniques
- Herpesvirus Infections and Treatments
- Advanced MRI Techniques and Applications
- Molecular Biology Techniques and Applications
- Meningioma and schwannoma management
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- Cardiac Valve Diseases and Treatments
- Surgical Simulation and Training
- Acute Ischemic Stroke Management
- Digital Radiography and Breast Imaging
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Cancer Cells and Metastasis
- Shoulder and Clavicle Injuries
- Genomics and Chromatin Dynamics
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Global Cancer Incidence and Screening
- Advanced Proteomics Techniques and Applications
The Ohio State University Wexner Medical Center
2011-2024
The Ohio State University
2014-2023
Westerly Hospital
2019-2020
Lung Institute
2020
Sir Ganga Ram Hospital
2018
KLE Society Hospital
2018
Neurological Surgery
2012-2017
Target (United States)
2017
Loughborough University
2016
University of Strathclyde
2016
AimsThe complex architecture of the human atria may create physical substrates for sustained re-entry to drive atrial fibrillation (AF). The existence sustained, anatomically defined AF drivers in humans has been challenged partly due lack simultaneous endocardial–epicardial (Endo–Epi) mapping coupled with high-resolution 3D structural imaging.
Bone marrow-derived cells including osteoblastic progenitors can be concentrated rapidly from bone marrow aspirates using the surface of selected implantable matrices for selective cell attachment. Concentration in this way to produce an enriched cellular composite graft improves efficacy. The current study was designed test hypothesis that biologic milieu a clot will significantly improve efficacy such graft. An established posterior spinal fusion model and cancellous matrix used compare...
MicroRNAs (miRNAs), single-stranded non-coding RNAs, influence myriad biological processes that can contribute to cancer. Although tumor-suppressive and oncogenic functions have been characterized for some miRNAs, the majority of microRNAs not investigated their ability promote modulate tumorigenesis. Here, we established miR-191/425 cluster is transcriptionally dependent on host gene, DALRD3, hormone 17β-estradiol (estrogen or E2) controls expression both DALRD3. MiR-191/425 locus...
Adverse metabolic changes associated with loss of ovarian function increase the risk developing syndrome and non-alcoholic fatty liver disease (NAFLD) in postmenopausal women. Naringenin improves disturbances vitro vivo. In present study, we tested effects naringenin on resulting from estrogen deficiency ovariectomized mice.Ovariectomized C57BL/6 J female mice were fed a control diet (10% calories fat) for 11 weeks. Mice either continued (n = 9) or switched to supplemented 3% 10) next Energy...
We have identified a role for two evolutionarily related, secreted metalloproteases of the ADAMTS family, ADAMTS20 and ADAMTS9, in palatogenesis. Adamts20 mutations cause mouse white-spotting mutant belted (bt), whereas Adamts9 is essential survival beyond 7.5 days gestation (E7.5). Functional overlap with was using Adamts9(+/-);bt/bt mice, which fully penetrant cleft palate. Palate closure delayed, although eventually completed, both Adamts9(+/-);bt/+ bt/bt demonstrating cooperation these...
The goal of this study was to develop a technique distinguish benign and malignant breast lesions in secondarily digitized mammograms. A set 51 mammograms (two views/patient) containing known pathology were evaluated using six different morphological descriptors: circularity, μ R /σ (where =mean radial distance tumor boundary, σ =standard deviation); compactness, P 2 / =perimeter length boundary =area the tumor); normalized moment classifier; fractal dimension; roughness (TBR) measurement...
Background: Long-standing tears of the rotator cuff can lead to substantial and perhaps irreversible changes in affected muscles. We developed a chronic tear canine model investigate quantify time-related passive mechanics, volume, fat infraspinatus muscle. hypothesized that muscle stiffness would increase, volume decrease, content increase at twelve weeks following tendon detachment. Methods: The right eight adult mongrel dogs were surgically detached from proximal part humerus. uninvolved...
Connective tissue progenitors can be concentrated rapidly from fresh bone marrow aspirates using some porous matrices as a surface for cell attachment and selective retention, creating cellular graft that is enriched with respect to the number of progenitor cells. We evaluated potential value this method demineralized cortical powder matrix. Matrix alone, matrix plus marrow, cells were compared in an established canine spinal fusion model. Fusions based on union score, mass, volume, by...
This study tested the hypothesis that pulsed electromagnetic field (PEMF) treatments augment and accelerate healing of bone trauma. It utilized micro-computed tomography imaging live rats had received bilateral 0.2 mm fibular osteotomies (approximately 0.5% acute loss) as a means to assess in vivo rate dynamics hard callus formation overall volume. Starting 5 days post-surgery, osteotomized right hind limbs were exposed 3 h daily Physio-Stim PEMF, 7 week for up weeks treatment. The...
Mutations in ADAMTS2, a procollagen amino-propeptidase, cause severe skin fragility, designated as dermatosparaxis animals, and subtype of the Ehlers-Danlos syndrome (dermatosparactic type or VIIC) humans. Not all collagen-rich tissues are affected to same degree, which suggests compensation by ADAMTS2 homologs ADAMTS3 ADAMTS14. In situ hybridization Adamts2, Adamts3 Adamts14, genes encoding major fibrillar collagens, Col1a1, Col2a1 Col3a1, during mouse embryogenesis, demonstrated distinct...
To quantify regional three-dimensional (3D) motion and myocardial strain using magnetic resonance (MR) tissue tagging in patients with non-ischemic dilated cardiomyopathy (DCM).MR grid tagged images were obtained multiple short- long-axis planes thirteen DCM patients. Regional 3D displacements strains calculated the aid of a finite element model. Five also imaged after LV volume reduction by partial left ventriculectomy (PLV), combined mitral tricuspid valve repair.DCM showed consistent,...
Abstract Background Inherited retinal degeneration is a leading cause of incurable vision loss in the developed world. While autologous iPSC mediated photoreceptor cell replacement theoretically possible, lack commercially available technologies designed to enable high throughput parallel production patient specific therapeutics has hindered clinical translation. Methods In this study, we describe use Cell X precision robotic culture platform grade iPSCs. The housed within an ISO Class 5...
Addition of an organophosphate source to UMR osteoblastic cultures activates a mineralization program in which BSP localizes extracellular matrix sites where hydroxyapatite crystals are subsequently nucleated (Wang, A., Martin, J. Lembke, L. and Midura, R. (2000) <i>J. Biol. Chem.</i> 275, 11082–11091). This study identifies for the first time novel spherical structures, termed biomineralization foci (BMF), containing bone acidic glycoprotein-75 (BAG-75), sialoprotein (BSP), alkaline...
Here, we describe the construction and testing of a novel herpes simplex virus type 1 (HSV-1) derived oncolytic (OV): 34.5ENVE (viral ICP34.5 Expressed by Nestin promotor Vstat120 Expressing), for treatment cancer. This showed significant glioma-specific killing antiangiogenic effects in vitro vivo. Treatment subcutaneous intracranial glioma-bearing mice with increase median survival four different glioma models. Histology dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)...
Neurodegenerative conditions that affect the retina are currently leading cause of incurable blindness in developed world. Although gene and drug therapies being to slow disease progression some cases, restorative cell replacement approaches needed for patients with significant vision impairment due retinal degeneration. While a variety different types have been evaluated context replacement, induced pluripotent stem cells (iPSCs), which can be generated delivered as an autologous...