A5055683624- Salivary Gland Disorders and Functions
- Pediatric health and respiratory diseases
- Toxic Organic Pollutants Impact
- Photoreceptor and optogenetics research
- Effects and risks of endocrine disrupting chemicals
- Neuroscience and Neuropharmacology Research
- Carcinogens and Genotoxicity Assessment
- Oral Health Pathology and Treatment
- Inflammasome and immune disorders
- Inflammatory mediators and NSAID effects
- Neural dynamics and brain function
- Autoimmune and Inflammatory Disorders Research
- Asthma and respiratory diseases
- Hormonal and reproductive studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Oral microbiology and periodontitis research
- Cancer Mechanisms and Therapy
- Estrogen and related hormone effects
- Obstructive Sleep Apnea Research
- Gut microbiota and health
- Bladder and Urothelial Cancer Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Prostate Cancer Treatment and Research
National Clinical Research Center for Digestive Diseases
2023-2025
Peking University
2021-2025
Changchun Children's Hospital
2024
First Hospital of Jilin University
2024
Jilin University
2024
Zhejiang Chinese Medical University
2014-2023
Fudan University
2019-2022
Shanghai Institute of Planned Parenthood Research
2017-2019
Abstract Objectives Burning mouth syndrome (BMS) is a chronic orofacial pain disorder with unclear etiology, in which the tongue most commonly affected. This study aims to provide implication of possible relationship between oral microbiota and pathogenesis BMS. Materials Methods Saliva swabs 15 primary BMS patients 10 healthy controls were collected assessed by 16S rRNA gene amplicon sequencing. The compositions compared bioinformatic analysis was conducted. Results Differences revealed...
Abstract Bisphenol A (BPA) is a well-known endocrine disruptor compound reported to have prostate toxicity. This study aimed assess the effect of BPA on proliferation dorsolateral (DLP) and expression epithelial–mesenchymal transition (EMT)-related genes in aged rats. Male SD rats were treated with (10.0, 30.0, 90.0 µg/kg i.g., daily) or vehicle (i.g., for 3 months. Treatment resulted increased PCNA, DLP weight epithelial height compared control group ( P < 0.01); such effects more...
Background The etiology of burning mouth syndrome (BMS) patients remains unclear and systemic conditions concurrently with BMS are viewed greater scrutiny. present study aimed to reveal whether gastroesophageal reflux disease (GERD) is the possible comorbidity BMS. Methods In our study, a real-world design was employed, enrolling from an oral medicine clinic capturing data in non-interventional, cross-sectional setting. Endoscopy Gastroesophageal Reflux Disease Questionnaire (GERDQ) were...
This study aimed to identify prostaglandin synthases (PGS) that mediate bisphenol A (BPA)-induced prostatic hyperplasia and explore their underlying mechanisms. In an in vivo study, male adult Sprague-Dawley rats were treated with different concentrations of BPA (10, 30, 90, or 270 μg/kg, i.g., daily), vehicle for 4 weeks. Results revealed low-dose induced increased PCNA/TUNEL ratio. It significantly upregulated the expression cyclooxygenase-2 (COX-2) NF-κB dorsolateral prostate (P < 0.05)...
Prostate is sensitive to endocrine hormone level, and the synergetic effect of estrogen androgen critical in prostate growth. The change signal pathways caused by imbalance might function occurrence diseases. As a well-known disruptor compound, bisphenol A (BPA) can disturb normal affect development. This study aims investigate effects BPA on dorsolateral (DLP) related gene expression tissue adult Sprague-Dawley (SD) rats explore mechanism for low-dose DLP hyperplasia. Three-month-old male...
Epilepsy is a circuit-level brain disorder characterized by hyperexcitatory seizures with unclear mechanisms. Here, we investigated the causal roles of calretinin (CR) neurons in posterior intralaminar thalamic nucleus (PIL) hippocampal seizures. Using c-fos mapping and calcium fiber photometry, found that PIL CR were activated during kindling model. Optogenetic activation accelerated seizure development, whereas inhibition retarded development. Further, viral-based circuit tracing verified...
The raphe nuclei, the primary resource of forebrain 5-HT, play an important but heterogeneous role in regulating subcortical excitabilities. Fundamental circuit organizations different median (MR) subsystems are far from completely understood. In present study, using cell-specific viral tracing, Ca2+ fiber photometry and epilepsy model, we map out efferent afferent MR Pet+ subpopulations their divergent roles epilepsy. We found that PetMR neurons send both collateral parallel innervations to...