A5002708870- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Acute Kidney Injury Research
- Potassium and Related Disorders
- Metal complexes synthesis and properties
- Vitamin C and Antioxidants Research
- Vitamin K Research Studies
- Protein Interaction Studies and Fluorescence Analysis
- Coenzyme Q10 studies and effects
- Hemoglobinopathies and Related Disorders
- Advanced battery technologies research
Benha University
2018-2022
Piroxicam (PM) is an oxicam-NSAID commonly recommended for various pain and associated inflammatory disorders. However, it reported to have a gastric hepato-renal toxic effect. Therefore, the current research was planned investigate possible mechanisms behind mitigating action of coenzyme (CoQ10), natural, free radical scavenger, against PM tissue injury. Rats were assigned five equal groups; Control, CoQ10 (10 mg/kg, orally), (7 i.p.), CoQ + L, H group. After 28 days, provoked severe...
Piroxicam (Px) is a non-steroidal anti-inflammatory drug that widely prescribed in various inflammatory disorders. However, Px known to induce gastric ulceration and hepato-renal toxicity. Rosuvastatin (ROSV), member of the statin family, has antioxidant actions independent its anti-hyperlipidemic action. Therefore, we investigated protective effects ROSV against Px-induced gastric, liver, kidney injury. Five groups seven rats each were used; control group, group (20 mg/kg, given orally), (7...
Although the combination of antibiotics is generally well-tolerated, they may have nephrotoxic effects. This study investigated whether tigecycline (TG) and gentamicin (GM) co-administration could accelerate renal damage. Male Wistar rats were randomly divided into six experimental groups: control, TG7 (tigecycline, 7 mg/kg), TG14 14 GM (gentamicin, 80 TG7+GM, TG14+GM groups. The TG evoked damage seen by disruption kidney function tests. perturbation tissue was mainly confounded to...
Tigecycline (TIG) toxicity is a threat to health because of the mortality risk attributed with its overdose. Large doses result in fatal cardiomyopathy and acute cardiotoxicity. Gentamicin (GEN) an aminoglycosidal antibacterial agent that affects kidney function then reabsorbed by renal tubules, causing nephrotoxicity. Six groups rats (n=5) were used. Control (DW), TIG 7, TIG14, GEN, 7+ 14+ GEN groups. Cardiac catalase (CAT) activity, glutathione (GSH), malondialdehyde (MDA) levels heart, as...
In most diseases, concurrent exposure to antibacterial is essential.The purpose of this research determine how co-administration the antibiotics gentamicin (an aminoglycoside) and tigecycline (a tetracycline) affects liver rats.Rats received distilled water, 7 (TIG 7), 14 (TIG14), (GEN), + gentamicin, groups.After 10 days, TIG and/or GEN caused tissue damage that seen in considerable biochemical changes assays functions.Also, a significant elevation AST, ALT, ALP, cholesterol, decrease...