A5088659798- Metal complexes synthesis and properties
- Click Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Ferrocene Chemistry and Applications
- Peptidase Inhibition and Analysis
- Synthesis and biological activity
- Molecular Sensors and Ion Detection
- Redox biology and oxidative stress
- Sulfur Compounds in Biology
- Hemoglobin structure and function
- Eicosanoids and Hypertension Pharmacology
- Inorganic Chemistry and Materials
- Heavy Metals in Plants
- DNA and Nucleic Acid Chemistry
- Analytical Chemistry and Sensors
- Nitric Oxide and Endothelin Effects
- Neuroscience of respiration and sleep
- Advanced biosensing and bioanalysis techniques
- Pharmacogenetics and Drug Metabolism
- Lanthanide and Transition Metal Complexes
- Semiconductor materials and devices
- Heavy metals in environment
- Genomics, phytochemicals, and oxidative stress
- Estrogen and related hormone effects
- Glutathione Transferases and Polymorphisms
Jilin Agricultural Science and Technology University
2022-2025
Southeast University
2017-2022
Fuyang Normal University
2013
Three organometallic Ru(arene) compounds bearing 7-hydroxycoumarin have been designed and synthesized. Resulting Ru(II) complexes 2–4 showed potent cytotoxicity against the tested cancer cell lines, much higher than either ligand L1 or unfunctionalized complex 1 alone. Further study indicated can activate expression of Bax, induce cytochrome c release from mitochondria, finally caspase-3, hinting that these probably apoptosis by mitochondrial pathway. Additional molecular docking potential...
Background Sika deer antler is a traditional Chinese medicine, and its mechanism of action on immune regulation still unclear. Therefore, this study aims to explore related mechanism. Purpose To investigate the by which velvet peptides (VAPs) from regulate function in mice through toll-like receptors 2 (TLR2)/toll-like 4 (TLR4) tumor necrosis factor-alpha (TNF-α)/interleukin-3 (IL-3)/recombinant cytotoxic T-lymphocyte-associated-antigen-4 (CTLA-4) signaling pathways. Methods Male ICR were...
Despite the wide clinical use of platinum drugs in cancer treatment, their severe side effects and lack tumor selectivity seriously limit further application. To address limitations current drugs, herein a multifunctional platinum(IV) compound 1 containing histone deacetylase (HDAC) inhibitor (4-phenylbutyric acid, 4-PBA) tumor-targeting group (biotin) has been designed prepared. An vitro cytotoxicity study indicated that exhibits comparable or superior to cisplatin against tested cell...
Triggered by UV light, the donor could release H<sub>2</sub>S to protect cells against damage of ROS and prompt cell survival rate, meanwhile turning on its fluorescence be monitored in real time.
As present NO donor drugs cannot localize to release at the hypoxic site, along with short half-life and bidirectional regulation of NO, they are unable overcome low bioavailability side effects in treatment myocardial hypoxia injury. In this study, we designed prepared a novel hypoxia-activated (Hano) by hybridization known compound (Nno) group. Hano isosorbide dinitrate were compared terms anti-myocardial Furthermore, Nno on releasing dilating blood vessels, preventing injury studied...
Abstract Subtle ligand modifications on Ru II ‐polypyridyl complexes may result in different excited‐state characteristics, which provides the opportunity to tune their photo‐physicochemical properties and subsequently change biological functions. Here, a DNA‐targeting complex (named Ru1 ) with highly photosensitizing 3 IL (intraligand) excited state was designed based classical DNA‐intercalator [Ru(bpy) 2 (dppz)] ⋅ PF 6 by incorporation of dppz (dipyrido[3,2‐ :2′,3′‐ c ]phenazine) tethered...
Dual-action Tam–Pt(<sc>iv</sc>) complexes increase the accumulation of platinum in ER-positive cancer cells and reverse resistance TamR-MCF-7 cell line.
The ratiometric fluorescent sensor L based on 8-hydroxyquinoline has been designed and synthesized. In aqueous media, exhibits a response to Ag+ in the presence of competing metal ions with large blue-shift 76 nm. good linear relationship is easily obtained between fluorescence changes concentrations range 0–80 μM. complexation mode proposed by titration, 1H NMR, IR MS mass spectrometer experiments.
Glutathione transferase (GST P1-1) is a potential target for anticancer drugs. In this work, series of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) derivatives as GST P1-1 inhibitors were designed, synthesized, and evaluated their biological activity. Among the compounds, 4n showed more selective inhibition toward M2-2, better water solubility, potent activities all tested cancer cells (except HOS) than its parent molecule. Detailed studies on effect 143b revealed that could...
The anticancer mechanism of NO is difficult to study owing its short lifetime and high reactivity. Thus, a theranostic donor assembled with on-demand release abilities, accurate lysosome location capabilities signal feedback behavior was developed. Profiting from the properties, specific comprehensively studied. Spectral cell imaging studies revealed that as prepared donors could in solution or within cancer cells. Fluorescence co-dyeing experiments demonstrated Mo-Nap-NO entered lysosomes...