A5040089910- Lymphatic System and Diseases
- Hippo pathway signaling and YAP/TAZ
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Axon Guidance and Neuronal Signaling
- Planarian Biology and Electrostimulation
- Extracellular vesicles in disease
- Wnt/β-catenin signaling in development and cancer
- Congenital heart defects research
- Zebrafish Biomedical Research Applications
- Angiogenesis and VEGF in Cancer
Peter MacCallum Cancer Centre
2020-2023
University of California, San Diego
2023
The University of Melbourne
2022-2023
The University of Queensland
2019-2023
University of Freiburg
2015
During development, the lymphatic vasculature forms as a second network derived chiefly from blood vessels. The transdifferentiation of embryonic venous endothelial cells (VECs) into (LECs) is key step in this process. Specification, differentiation and maintenance LEC fate are all driven by transcription factor Prox1, yet downstream mechanisms remain to be elucidated. We here present single-cell transcriptomic atlas lymphangiogenesis zebrafish, revealing new markers hallmarks over four...
Development of the dorsal aorta is a key step in establishment adult blood-forming system, since hematopoietic stem and progenitor cells (HSPCs) arise from ventral aortic endothelium all vertebrate animals studied. Work zebrafish has demonstrated that arterial venous endothelial precursors distinct subsets lateral plate mesoderm. Here, we profile transcriptome earliest detectable (ECs) during embryogenesis to demonstrate tissue-specific EC programs initiate much earlier than previously...
During development, proliferation must be tightly controlled for organs to reach their appropriate size. While the Hippo signaling pathway plays a major role in organ growth control, how it senses and responds increased cell density is still unclear. In this study, we use zebrafish lateral line primordium (LLP), group of migrating epithelial cells that form sensory organs, understand tissue during formation. Loss junction-associated Motin protein Amotl2a leads overproliferation bigger LLP,...
Lymphatic vascular development involves specification of lymphatic endothelial progenitors that subsequently undergo sprouting, proliferation and tissue growth to form a complex second vasculature. The Hippo pathway effectors Yap Taz control organ regulate morphogenesis cellular proliferation. angiogenesis but role in lymphangiogenesis remains be fully elucidated. Here we show YAP displays dynamic changes Yap1 is essential for zebrafish. Maternal Zygotic (MZ) yap1 mutants normal progenitors,...
During development, the lymphatic vasculature forms as a second, new vascular network derived from blood vessels. The transdifferentiation of embryonic venous endothelial cells (VECs) into (LECs) is first step in this process. Specification, differentiation and maintenance LEC fate are all driven by transcription factor Prox1, yet downstream mechanisms remain to be elucidated. We present single cell transcriptomic atlas lymphangiogenesis zebrafish revealing markers hallmarks over four...
Lymphangiogenesis is a dynamic process that involves the directed migration of lymphatic endothelial cells (LECs) to form vessels. The molecular mechanisms underpin vessel patterning are not fully elucidated and, date, no global regulator guidance known. In this study, we identify transmembrane cell signalling receptor Plexin D1 (Plxnd1) as negative both and lymphangiogenesis in zebrafish. plxnd1 expressed developing lymphatics required for trunk facial networks. Loss associated with...