A5037350460- Synthesis of Indole Derivatives
- Carbohydrate Chemistry and Synthesis
- Oxidative Organic Chemistry Reactions
- Marine Toxins and Detection Methods
- Bioactive Compounds and Antitumor Agents
- Glycosylation and Glycoproteins Research
- Pneumonia and Respiratory Infections
- Synthetic Organic Chemistry Methods
- Organic Electronics and Photovoltaics
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Organic Light-Emitting Diodes Research
- Respiratory viral infections research
- Galectins and Cancer Biology
- Crystallization and Solubility Studies
- Immunotherapy and Immune Responses
- Synthesis and Biological Activity
- Legume Nitrogen Fixing Symbiosis
- Conducting polymers and applications
- Polyamine Metabolism and Applications
- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- Synthesis of Organic Compounds
- Synthesis and Biological Evaluation
Seoul National University of Science and Technology
2019
Max Planck Institute of Colloids and Interfaces
2014-2018
Freie Universität Berlin
2015-2017
Yonsei University
2015
University of Auckland
2008-2012
Maurice Wilkins Centre
2010
Fully synthetic glycan-based vaccines hold great potential as preventive and therapeutic against infectious diseases well cancer. Here, we present a two-component platform based on the facile conjugation of carbohydrate antigens to α-galactosylceramide (α-GalCer) yield fully vaccine candidates. Formulation cancer-associated Tn antigen glycolipid model candidate into liposomes different sizes subsequent immunization mice generated specific, high-affinity antibodies with characteristics T...
Balancing act: The correct balance of electronic factors in the naphthazarin and isocoumarin fragments facilitates acid-mediated spiroketalization step to afford key densely functionalized spiroketal (see picture; EOM=ethoxymethyl) formal synthesis (±)-γ-rubromycin. A novel regioselective allyloxylation/Claisen rearrangement 2-azido-1,4-naphthoquinone provides access highly oxygenated fragment. Detailed facts importance specialist readers are published as "Supporting Information". Such...
Dual-modal fluorescent magnetic glyconanoparticles have been prepared and shown to be powerful in probing lectins displayed on pathogenic mammalian cell surfaces. Blood group H1- Leb-conjugated nanoparticles were found bind BabA displaying Helicobacter pylori, Lea- Leb-modified are both recognized by internalized into DC-SIGN SIGN-R1 expressing cells via lectin-mediated endocytosis. In addition, block adhesion of H. pylori cells, suggesting that they can serve as inhibitors infection host...
A<italic>Haemophilus influenzae</italic>b vaccine lead antigen was identified by the immunological evaluation of chemically precisely defined capsular polysaccharide repeating unit oligosaccharides.
Studies toward the synthesis of three biologically active [5,6]-benzannulated spiroketal natural products are described. The first total paecilospirone is reported, employing a late-stage, pH-neutral spiroketalization. A formal γ-rubromycin described, where moiety formed by delicate manipulation electronic properties spirocyclization precursor. Finally, model work berkelic acid summarized, introducing novel Horner–Wadsworth–Emmons/oxa-Michael (HWE/oxa-M) cascade to access
Host-guest structures are used in most state-of-the-art organic light-emitting devices, with the host transporting charge and confining excitons on guest. While often plays a critical role achieving high efficiency stability, predicting understanding these effects is persistent design challenge which slows discovery of new active materials. Closely related molecules, differ only by several functional groups, show drastically different degradation behavior. Here, we explore this observation...
The synthesis of a series 5,5-, 5,6-, and 6,6-monobenzannulated spiroketals using novel cross-metathesis-radical-cyclisation approach is reported. Cross metathesis between two olefin coupling partners resulted in the formation heterodimer which upon hydrogenation furnished saturated alcohol product. Oxidative radical cyclisation then afforded desired monobenzannulated good overall yield.
Abstract We demonstrate improved stability in phosphorescent organic light‐emitting devices (OLEDs) by incorporating a wide energy gap host material into an ambipolar emissive layer. Unlike conventional mixed‐host OLEDs that combine hole‐ and electron‐transporting hosts, charge transport this device occurs primarily along the emitter, while serves to modify injection characteristics of This approach allows both width position exciton recombination zone be tuned without introducing exciplex...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract Review: 43 refs.
Abstract Review: 119 refs.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
In the crystal structure of title compound, C(16)H(16)O(6), a pair naphthoquinone rings are linked via O-H⋯O-C hydrogen bonds in nearly orthogonal arrangement. This dimeric unit is to neighbouring dimer by π-π stacking inter-actions between rings, where distance mean plane naphtoquinone backbones 3.468 Å, and bonds.