A5002284785- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Glycosylation and Glycoproteins Research
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Pharmacological Effects and Toxicity Studies
- Trace Elements in Health
- Monoclonal and Polyclonal Antibodies Research
- Graphene and Nanomaterials Applications
- Lipid Membrane Structure and Behavior
- Supramolecular Self-Assembly in Materials
University of Massachusetts Amherst
2023-2024
University of Massachusetts Lowell
2019-2023
ConspectusNanoparticles (NPs) have incredible potential in biology and biomedicine. Gold nanoparticles (AuNPs) become a cornerstone of the nanomedicine revolution due to their ease synthesis, inertness, versatility. The widespread use AuNPs can be traced development accessible, bottom-up wet synthesis methods that emphasized role ligands controlling size, dispersity, stability colloids solution. Decoration with organic used dictate interactions these nanomaterials biosystems on multiple...
Abstract In this work, we show that the addition of thiourea (TU) initiated broad‐spectrum antimicrobial activity otherwise inactive D‐maltose‐capped gold nanoclusters (AuNC‐Mal). For example, AuNC‐Mal/TU was effective against multidrug‐resistant Pseudomonas aeruginosa with a minimum inhibitory concentration (MIC) 1 μg mL −1 (2.5 μM [Au]) while having 30–60 times lower in vitro cytotoxicity mammalian cells. The reaction AuNC‐Mal and TU generated species [Au(TU) 2 ] + smaller AuNCs. increased...
Abstract Synthetic polymer scaffolds can encapsulate transition metal catalysts (TMCs) to provide bioorthogonal nanocatalysts. These “polyzymes” catalyze the in situ generation of therapeutic agents without disrupting native biological processes. The design and modification these polyzymes enhance catalytic performance TMCs environments. In this study, we explore hydrophobic space an oxanorborneneimide‐based by varying length its carbon side chain engineer polyzymes. Activity studies...
Abstract Auranofin, a gold(I)‐complex with tetraacetylated thioglucose (Ac 4 GlcSH) and triethylphosphine ligands, is an FDA‐approved drug used as anti‐inflammatory aid in the treatment of rheumatoid arthritis. In repurposing auranofin for other diseases, it was found that showed significant activity against Gram‐positive but inactive Gram‐negative bacteria. Herein, design synthesis gold nanoclusters (AuNCs) based on structural motif are reported. Phosphine‐capped AuNCs synthesized...
Gupta, Aarohi; Ndugire, William; Liu, Liang; Chakraborty, Soham; Elaziz, Maged Abd; Rainboth, Derek; Rotello, Vincent M. Author Information
Liposomes, a nanoscale drug delivery system, are well known for their ability to improve pharmacokinetics and reduce toxicity. In this work, maltoheptaose (G7)-presenting glycoliposomes were synthesized evaluated in the of antibiotic rifampicin. Two types liposomes prepared: nonfluid from l-α-phosphatidylcholine (PC) cholesterol, fluid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine 1,2-dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol). G7-derivatized glycolipid, G7-DPPE (DPPE:...
Glycopolymers have gained increasing importance in investigating glycan-lectin interactions, as drug delivery vehicles and modulating interactions with proteins. The synthesis of these glycopolymers is still a challenging rigorous exercise. In this regard, the highly efficient click reaction, copper (I)-catalyzed alkyne-azide cycloaddition, has been widely applied not only for its efficiency but also tolerance appended carbohydrate groups. However, significant drawback method use heavy metal...
Water-soluble gold nanoclusters (AuNCs) are popular in biomedical applications such as bioimaging, labelling, drug delivery, and biosensing. Despite their widespread applications, the synthesis of water-soluble phosphine-capped AuNCs is not straightforward organic-soluble equivalents. Organic soluble phosphine-passivated [Au9(L)8]3+ 6-electron closed-shell that generally prepared via reduction a phosphine-Au(I) complex by NaBH4. A similar approach attempted for ligand triphenylphosphine...
Bio-orthogonal chemistry provides a powerful tool for drug delivery systems due to its ability generate therapeutic agents in situ, minimizing off-target effects. transition metal catalysts (TMCs) with stimuli-responsive properties offer possibilities controllable catalysis their spatial-, temporal-, and dosage-controllable properties. In this paper, we fabricated bio-orthogonal system based on an enhanced green fluorescent protein (EGFP)–nanozyme (NZ) complex (EGFP-NZ). Regulation of the...
Abstract In this work, we show that the addition of thiourea (TU) initiated broad‐spectrum antimicrobial activity otherwise inactive D‐maltose‐capped gold nanoclusters (AuNC‐Mal). For example, AuNC‐Mal/TU was effective against multidrug‐resistant Pseudomonas aeruginosa with a minimum inhibitory concentration (MIC) 1 μg mL −1 (2.5 μM [Au]) while having 30–60 times lower in vitro cytotoxicity mammalian cells. The reaction AuNC‐Mal and TU generated species [Au(TU) 2 ] + smaller AuNCs. increased...
In this work we show that biological inactive gold nanoclusters (AuNCs) capped with D-maltose can be converted to antimicrobial AuI species by the addition of thiourea (TU). The activity mainly arises from reaction AuNCs TU generating [Au(TU)2]Cl and small Au nanoclusters. Excess also maintains oxidation state as (vs. AuIII) which is key in maintaining activity. AuNCs/TU combination was a powerful bactericidal agent against resistant bacteria, including multidrug-resistant (MDR) clinical...
In this work we show that biological inactive gold nanoclusters (AuNCs) capped with D-maltose can be converted to antimicrobial AuI species by the addition of thiourea (TU). The activity mainly arises from reaction AuNCs TU generating [Au(TU)2]Cl and small Au nanoclusters. Excess also maintains oxidation state as (vs. AuIII) which is key in maintaining activity. AuNCs/TU combination was a powerful bactericidal agent against resistant bacteria, including multidrug-resistant (MDR) clinical...
Auranofin, a gold(I)-complex with tetraacetylated thioglucose and triethylphosphine ligands, is an FDA-approved drug used as anti-inflammatory aid in the treatment of rheumatoid arthritis. In repurposing auranofin for other diseases, it was found that showed significant activity against Gram-positive bacteria but inactive Gram-negative bacteria. Herein, we report design synthesis gold nanoclusters (AuNCs) based on structural motif auranofin. Phosphine-capped AuNCs were synthesized...
Auranofin, a gold(I)-complex with tetraacetylated thioglucose and triethylphosphine ligands, is an FDA-approved drug used as anti-inflammatory aid in the treatment of rheumatoid arthritis. In repurposing auranofin for other diseases, it was found that showed significant activity against Gram-positive bacteria but inactive Gram-negative bacteria. Herein, we report design synthesis gold nanoclusters (AuNCs) based on structural motif auranofin. Phosphine-capped AuNCs were synthesized...