A5037907612- Chemical Synthesis and Reactions
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Microplastics and Plastic Pollution
- Gastrointestinal Tumor Research and Treatment
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Analysis
- Antimicrobial Peptides and Activities
- Gastric Cancer Management and Outcomes
- Enzyme Production and Characterization
- Immune Response and Inflammation
- Catalysis and Hydrodesulfurization Studies
- biodegradable polymer synthesis and properties
- Virus-based gene therapy research
- Helicobacter pylori-related gastroenterology studies
- Polyoxometalates: Synthesis and Applications
- Immunotherapy and Immune Responses
- Biopolymer Synthesis and Applications
- Water Quality Monitoring and Analysis
- Wind and Air Flow Studies
- Immune Cell Function and Interaction
- interferon and immune responses
- Wheat and Barley Genetics and Pathology
- Selenium in Biological Systems
- Water Treatment and Disinfection
Shandong University
2022-2025
Ocean University of China
2024
Guangxi University of Chinese Medicine
2023-2024
Guangxi University
2024
Jiangsu Normal University
2005-2023
Fujian Medical University
2022-2023
Nanjing Normal University
2023
Hunan Normal University
2005-2022
Xi'an University of Architecture and Technology
2019
Harbin Medical University
2013
Polyploids generally possess superior K+/Na+ homeostasis under saline conditions compared with their diploid progenitors. In this study, we identified the physiological mechanisms involved in ploidy-related mediation of roots (2x) and hexaploid (6x; autohexaploid) Ipomoea trifida, which is closest relative cultivated sweet potato. Results showed that 6x I. trifida retained more K+ accumulated less Na+ root leaf tissues salt stress than 2x trifida. Compared its ancestor, efficiently prevents...
Fully biomass-derived bioplastic packaging can potentially mitigate plastic pollution. Herein, we showed that bioplastics be generated from pullulan, lactate-nanocellulose (laNC), or hydrophobic lignin (HBL) using simple engineering techniques. Both laNC and HBL were extracted corn stalks with yields of 22.1% ± 0.5% 13.7% 0.6%, respectively, a recyclable, eco-friendly, lactic acid–glycine deep eutectic solvent. The fine dispersion in pullulan (20 mg/g) resulted bionanocomposite film (PNC20)...
Biohybrid systems that integrate microorganisms with nanomaterials have emerged as promising solutions for sustainable nitrogen fixation. However, key challenges, such the dependence on light and vulnerability of nitrogenase to oxidative damage, limited their application. Here, we report a novel, light-independent biohybrid system integrating Fe3O4 nanoparticles Methanosarcina acetivorans C2A, resulting in significant enhancement both fixation activity methane production. facilitate...
Abstract. The urban canopy layer (UCL) is strongly affected by human activities, with rough elements and anthropogenic heat sources enhancing turbulence complexity. In basin cities, the terrain further complicates influence of structures on haze pollution processes, which still remains unclear. Based field observations in Lanzhou, China, this study identified a typical evolution pattern UCL: PM2.5 concentrations rose from 08:00–13:00, declined 14:00–18:00, again 19:00–21:00, 22:00–07:00....
Glycoconjugation is a promising modification strategy for the optimization of peptide drugs. In this study, five different monosaccharide derivatives (7a–e) were covalently linked to N-terminal R-lycosin-I, which yielded glycopeptides (8a–e). They demonstrated increased or reduced cytotoxicity depending on types, might be explained by changes physicochemical properties. Among all synthesized glycopeptides, only 8a exhibited (IC50 = 9.6 ± 0.3 μM) and selectivity 37.4 5.9 μM). The glucose...
The toxicity of nanoparticles to freshwater microalgae is significant importance in maintaining the overall stability aquatic ecosystems. However, transport mechanism and response towards nanoplastics (NPs) remain be further investigated. In this study, we examined internalization mechanisms polystyrene (PS-NPs) microalga Chlorella sorokiniana. results revealed that PS-NPs inhibited algal cells' growth disrupted cell integrity upon contact, leading shrinkage or rupture. Moreover,...
As essential primary producers, cyanobacteria play a major role in global carbon and nitrogen cycles. Though the influence of nanoplastics on metabolism is well-studied, little known about how affect their metabolism, especially under environmentally relevant concentrations. Here, we show that forms regulated growth inhibition, consumption, synthesis release microcystin (MC) Microcystis aeruginosa exposed to 10 μg/mL amino-modified polystyrene (PS-NH2) with particle size 50 nm concentrations...
Peptide modification with fatty acids is an effective method to improve peptide performance. We previously investigated the acid of R-lycosin-I, a cytotoxic derived from lycosin-I venom spider Lycosa singoriensis. In this study, we further position effects lycosin-I. Dodecanoic was covalently coupled α/ε-amino group one seven Lys residues lycosin-I, generating eight different lipopeptides. Although all lipopeptides had significantly improved cytotoxicity compared they displayed potencies and...
We previously reported that R-lycosin-I, modified by amino acid substitution from lycosin-I, was a peptide with anticancer activity and linear amphipathic α-helix conformation it can induce cancer cell apoptosis inhibit proliferation. However, the of R-lycosin-I not highly improved. In order to further improve fatty acids different chain lengths 12 20 carbons were introduced N-terminal yield five lipopeptides (R-C12, R-C14, R-C16, R-C18, R-C20). The physicochemical properties determined...
Seed priming with nanomaterials is an emerging approach for improving plant stress tolerance. Here, we demonstrated a mechanism enhancing salt tolerance in rice under via nonstimulatory nanoparticles such as selenium (SeNPs), distinct from stimulatory nanomaterials. Due to the dynamic transformation ability of SeNPs, SeNP could enhance by mediating glutathione cycle eliminate excess reactive oxygen species (ROS). During priming, SeNPs penetrated seeds and transitioned into soluble form...
Glucagon-like peptide-1 (GLP-1) receptor agonists modified with albumin ligands which can specificity bind to the human serum (HSA) was an efficient strategy prolong half-time of GLP-1. Herein, we investigated effect small-molecule ligand modification on hypoglycemic activities GLP-1 derivatives. Two derivatives MPA-C12-GLP-1 and Rhein-C12-GLP-1 were achieved by side chain amino lysine in position 26 Arg34-GLP-1(7-37)-OH Rhein 3-Maleimidopropionic acid respectively using 12-aminolauric as a...
Probing the single-cell mechanobiology in situ is imperative for microbial processes medical, industrial, and agricultural realms, but it remains a challenge. Herein, we present force microscopy method that can be used to measure adhesion strength under anaerobic conditions situ. This integrates atomic with an liquid cell inverted fluorescence microscopy. We obtained nanomechanical measurements of single bacterium Ethanoligenens harbinense YUAN-3 methanogenic archaeon Methanosarcina...
A cationic lipid consists of a hydrophilic headgroup, backbone and hydrophobic tails which have an immense influence on the transfection efficiency lipid. In this paper, two novel series cyclic glycolipids with quaternary ammonium headgroup different-length (dodecyl, tetradecyl, hexadecyl) been designed synthesized for gene delivery. One contains lipids 1-3 alkyl chains linked to glucose ring directly via ether link. The other 4-6 positively charged nitrogen atoms. All were characterized...
Herein, we report practical Cu(BF4)2/activated carbon-catalyzed amination of various anilines, isoquinolinone, and naphthyridinone with aryl boronic acids. The ultrasonic rotary evaporation treatment the mixture aq. Cu(BF4)2 activated carbon in methanol afforded a novel Cu(II)-catalyst, which is air-stable can be effectively applied Chan–Lam coupling reaction. products N-arylation were isolated good to excellent yields at low catalytic loading. And Cu(BF4)2/AC also showed reusability.
Galectin-3 is involved in many physical and pathologic process, closely correlated with tumorigenesis, development metastasis. The aim of this study to investigate the gene expression significance normal lung tissue non-small cell cancer (NSCLC) tissue.Gene was examined using immunohistochemical S-P method 62 NSCLC cases 17 tissue. RT-PCR verified at transcriptional level.The rate 83.8% (52/62), which significantly higher than that (P<0.01). not sex (χ²=0.113, P>0.05), age (χ²=0.220,...
In this paper, three cationic glycolipids with different hydrophobic chains Malt-DiC12MA (IX a), Malt-DiC14MA b) and Malt-DiC16MA c) were constructed by using maltose as starting material via peracetylation, selective 1-O-deacetylation, trichloroacetimidation, glycosylation, azidation, deacetylation, Staudinger reaction, tertiary amination quaternization. Target compounds some intermediates characterized ¹H-NMR, 13C-NMR, ¹H-¹H COSY ¹H-13C HSQC. The results of gel electrophoresis assay,...