A5016359744- Pesticide Residue Analysis and Safety
- Pesticide and Herbicide Environmental Studies
- Carcinogens and Genotoxicity Assessment
- Agricultural safety and regulations
- Pesticide Exposure and Toxicity
- Thyroid Disorders and Treatments
- Effects and risks of endocrine disrupting chemicals
- Insect and Pesticide Research
- Cannabis and Cannabinoid Research
- Polyamine Metabolism and Applications
- GABA and Rice Research
- Radiopharmaceutical Chemistry and Applications
- Dental Anxiety and Anesthesia Techniques
- Genetically Modified Organisms Research
- Chemical Analysis and Environmental Impact
- Bioactive natural compounds
- Anesthesia and Pain Management
- Immunotoxicology and immune responses
- Chemical Safety and Risk Management
- Orthopedic Surgery and Rehabilitation
- Biotin and Related Studies
- Biopolymer Synthesis and Applications
- Landslides and related hazards
- Pharmacogenetics and Drug Metabolism
- Botanical Research and Chemistry
Federal Institute for Risk Assessment
2019-2024
Karlsruhe University of Education
2019
Abstract Alterations in thyroid hormones (TH) and thyroid-stimulating hormone levels are frequently found following exposure to chemicals of concern. Dysregulation TH can severely perturb physiological growth, metabolism, differentiation, homeostasis the adult developmental processes utero. A identified mode action for this interaction is induction hepatic detoxification mechanisms (e.g. SULTs UGTs), which lead conjugation elimination therefore interfere with hormonal homeostasis, fulfilling...
Abstract In 2012 the EFSA Panel on Plant Protection Products and their Residues, pointed out to need for a well‐curated database of genotoxicity data support reliable use in silico methods predicting chemicals this domain. Subsequently, developed extracted from submitted course regulatory approval pesticides, was used test performance existing tools genotoxicity. It concluded that, at present, QSAR works well Ames mutagenicity, but not other endpoints. BfR has its own internal curated...
Abstract Currently, the authorisation process for plant protection products (PPPs) relies on testing of acute and topological toxicity only. Contrastingly, evaluation active substances includes a more comprehensive set studies. Nevertheless, mixture effects ingredients co-formulants may result in increased toxicity. Therefore, we investigated surface two PPPs focussing qualitative quantitative toxicokinetic absorption secretion. The respective are based abamectin fluroxypyr-meptyl were...
The assessment of human health risks resulting from the presence metabolites in groundwater and food residues has become an important element pesticide authorisation. In this context, evaluation mutagenicity is particular interest a paradigm shift exposure-triggered testing to silico-based screening been recommended European Food Safety Authority (EFSA) Guidance on establishment residue definition for dietary risk assessment. addition, it proposed apply silico predictions when experimental...
Genotoxicity assessment is a key component of regulatory decision-making in pesticide authorization and biocide approval. Conventionally, these genotoxicity requirements are addressed with OECD test guideline-compliant vitro tests. In recent years, silico approaches, such as (Q)SAR, have matured sufficiently so that they may be suitable to support, complement or even replace testing first tier assessment. Among the different endpoints for genotoxicity, high reliability expected predictions...
Legal frameworks lay down requirements for risk assessment of combined exposure to multiple chemicals and their implementation where scientific methods are accepted by responsible authorities. In order protect human health, an potential risks that might result from co-exposure chemical substances is requested European legislation. Several approaches mixtures have been proposed, but none has widely implemented in regulatory assessments, so far. EuroMix, EU Horizon 2020 funded project,...
Plant protection products (PPPs) consist of one or more active substances and several co-formulants. Active provide the functionality PPP are consequently evaluated according to standard test methods set by legal data requirements before approval, whereas co-formulants' toxicity is not as comprehensively assessed. However, in some cases mixture effects co-formulants might result increased different forms toxicity. In a proof-of-concept study we hence built on previously published results...
Abstract The quinolizidine alkaloids matrine and its N-oxide oxymatrine occur in plants of the genus Sophora. Recently, was sporadically detected liquorice products. Morphological similarity plant Glycyrrhiza glabra with Sophora species resulting confusion during harvesting may explain this contamination, but use as pesticide has also been reported. detection products raised concern some studies suggested a genotoxic activity oxymatrine. However, these are fraught uncertainties, putting...