A5076637826- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Pleural and Pulmonary Diseases
- Gastroesophageal reflux and treatments
- Transplantation: Methods and Outcomes
- Advanced Radiotherapy Techniques
- Organ Transplantation Techniques and Outcomes
- Metastasis and carcinoma case studies
- Head and Neck Cancer Studies
- CAR-T cell therapy research
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal Tumor Research and Treatment
- Myasthenia Gravis and Thymoma
- Medical Imaging and Pathology Studies
- Helicobacter pylori-related gastroenterology studies
- Cancer Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Dysphagia Assessment and Management
Brigham and Women's Hospital
2016-2025
Harvard University
2015-2024
Dana-Farber Cancer Institute
2011-2024
Brown University
2024
Stanford Medicine
2024
Dana-Farber Brigham Cancer Center
2010-2016
Boston University
2015
One of the major hurdles that has hindered success chimeric antigen receptor (CAR) T cell therapies against solid tumors is on-target off-tumor (OTOT) toxicity due to sharing same epitopes on normal tissues. To elevate safety profile CAR-T cells, an affinity/avidity fine-tuned CAR was designed enabling activation only in presence a highly expressed tumor associated (TAA) but not when recognizing at physiological level healthy cells. Using direct stochastic optical reconstruction microscopy...
Purpose To facilitate localization and resection of small lung nodules, we developed a prospective clinical trial (ClinicalTrials.gov number NCT01847209) for novel surgical approach which combines placement fiducials using intra-operative C-arm computed tomography (CT) guidance with standard thoracoscopic technique image-guided video-assisted surgery (iVATS). Methods Pretrial training was performed in porcine model CT needle software. Methodology workflow iVATS developed, multi-modality team...
Abstract Tumor progression and metastasis is driven by interplays between cancer cells their surrounding tumor microenvironment (TME). Investigating the spatiotemporal transcriptomic profile of primary metastatic tumors sheds light on how differences in spatial architecture shape TME promote metastasis. Here, we profiled three lung clear cell renal carcinoma (ccRCC) samples using CosMx platform, which provides a 999-gene transcriptome with coordinates. After segmentation annotation, further...
Purpose To examine the frequency and potential of dose-volume predictors for chest wall (CW) toxicity (pain and/or rib fracture) patients receiving lung stereotactic body radiotherapy (SBRT) using treatment planning methods to minimize CW dose a risk-adapted fractionation scheme. Methods We reviewed data from 72 plans, 69 SBRT with at least one year follow-up or toxicity, who were treated our center between 2010 2013. Treatment plans optimized reduce received 18 Gy×3 fractions (54 Gy total)...
Induction therapy followed by esophagectomy has become standard for treatment of intermediate-stage esophageal cancer in many centers. Herein we evaluate the feasibility and safety 3-hole minimally invasive (3HMIE) approach patients who received induction radiation chemotherapy. Between 2003 2012, records 119 consecutive with underwent 3HMIE were reviewed perioperative complications long-term outcomes. Comparison was made between procedures performed receiving neoadjuvant chemoradiation...
Abstract Introduction Postoperative delirium is a common complication after major surgical procedures and affects outcomes long‐term survival. We identified factors associated with postoperative in patients undergoing esophagectomy. Methods Retrospective cohort analysis of 378 examined the association between (DSM‐V) criteria respect to baseline variables complications. Results was diagnosed 64 (16.93%) increasing age ( P < .05), chronic obstructive pulmonary disease = .07), pneumonia...
Gastroesophageal reflux has been associated with poorer lung transplantation outcomes, although no standard approach to evaluation/management adopted. We aimed evaluate the effect of timely antireflux treatment as guided by routine testing on postlung transplant rejection outcomes.This was a retrospective cohort study recipients at tertiary center. All patients underwent pretransplant ambulatory pH monitoring. Timely defined proton pump inhibitor initiation or surgery within 6 months...