A5041238383- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Medical and Biological Sciences
- Thyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Hypothalamic control of reproductive hormones
- Pancreatic function and diabetes
- Genetic and rare skin diseases.
- Adrenal Hormones and Disorders
- Child and Adolescent Health
- Congenital heart defects research
- Pediatric Hepatobiliary Diseases and Treatments
- Skin and Cellular Biology Research
- Medicine, History, and Philosophy
- Pituitary Gland Disorders and Treatments
- Medical History and Innovations
- Neuroendocrine regulation and behavior
- Skin Diseases and Diabetes
- Diabetes and associated disorders
- Blood disorders and treatments
- Biochemical effects in animals
- Diabetes Treatment and Management
- Thyroid Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Hormonal and reproductive studies
Saint Petersburg State Pediatric Medical University
2016-2024
Ministry of Health of the Russian Federation
2016
Somatrogon is a long-acting recombinant human growth hormone (GH) employed as once-weekly treatment for children with GH deficiency (GHD). A 12-month, phase 2 study of somatrogon vs. once-daily (Genotropin®) was initiated, after which participants could enroll into an open-label extension (OLE) evaluating the safety and efficacy long-term treatment.There were five periods, Periods I II 6 months each while III, IV, V 12 each. In main (Periods II), 53 prepubertal GHD randomized to (0.25, 0.48,...
Abstract Context: TransCon Growth Hormone (GH) (Ascendis Pharma) is a long-acting recombinant sustained-release human GH prodrug in development for children with deficiency (GHD). Objective: To compare the pharmacokinetics, pharmacodynamics, safety, and efficacy of weekly to that daily prepubertal GHD. Design: Randomized, open-label, active-controlled study three doses versus Genotropin (Pfizer). Setting: Thirty-eight centers 14 European countries Egypt. Patients: Prepubertal male female...
Abstract Disclosure: Z. Zadik: None. N. Zelinska: Consulting Fee; Self; Novo Nordisk, Berlin-Chemie, Medtronic, Sanofi-Aventis. Research Investigator; MacroGenics, Pfizer, Inc., Merck, OPKO Health, Ferring Pharmaceuticals, Teva Pharmaceutical Industries Ltd., Parexel, Genexine. Speaker; ACINO, Sanofi-Aventis, Johnson &Johnson, Wörwag Pharma. V. Iotova: Grant Recipient; Inc. Swixx, Sandoz, Berlin-Chemie. Y. Skorodok: O.A. Malievskiy: Mauras: Agios. Abbvie. Abbvie, Beta Bionics. S.R....
BACKGROUND : Differential diagnosis of hypogonadotropic hypogonadism (HH) and constitutional delay puberty (CDP) is extremely important since with the latter begins completes without any medical intervention in case HH does not occur or incomplete. Failure to start treatment on time leads psychosocial maladjustment patient. AIM Development a method for differential boys 13.5–17 years old by scoring levels LH, FSH, testosterone inhibin B. MATERIALS AND METHODS The study group was formed...
The main purpose of research was to study and evaluate the featres diagnosis differentiated thyroid carcinoma children adolescents. total 63 patients with cancer who had undergone surgery in 1994-2013 heir hildhood were examined. history, clinical symptoms, results pre- postoperative instrumental laboratory studies analyzed. showed that three-quarters do not complain. Medical examinations teenagers allowed reveal disease more than half cases. Significant place diagnostics occupies ultrasound...
Endocrinology, one of the most dynamically developing branches medicine, has existed as a separate discipline for little over 100 years. The author first guidelines on endocrinology in Russia and founder Leningrad School Clinical Endocrinology was Professor Vasily G. Baranov (1899–1988). In 1926, an department opened at Department Therapy State Institute Advanced Medical Training under leadership Gavrilovich. Later, 1963, V.G. founded this educational institution, which currently bears name...
Abstract Background: Somatrogon, a long-acting recombinant human growth hormone, is being developed as once weekly treatment for pediatric patients (pts) with GHD. A phase 2, 12 month study (NCT01592500) in pts GHD showed that somatrogon at 0.66 mg/kg/week had similar efficacy and safety to daily Genotropin. Pts who completed months of could be enrolled into an open-label extension (OLE). Aims: Evaluate the long-term exposure continued OLE up additional 5 years. Methods: Methods main 2 were...
Endocrine diseases such as obesity, diabetes mellitus, Cushings syndrome, hypothyroidism and hyperthyroidism, acromegaly hyperandrogenism in children adolescents are often manifested by changes the skin. Moreover, skin symptoms can be a marker of systemic, this case, endocrine metabolic diseases. Obesity chronic that affect people all over world, their incidence is increasing both adults. Clinically, they number organs, including The cutaneous manifestations caused or aggravated obesity...
The article provides the literary information and results of our own research on structure thyroid nodules in operated children.The clinical significance nodular neoplasms gland is determined by relatively high risk carcinomas. Along with this, relevance this due to increasing surgical interventions fact that features children tactics management patients remain debatable.The aim work was study childrenin various age groups. case histories 225 childrenfrom 4 17 years oldfrom 2007 2017 were...
BACKGROUND: In patients with a constitutional delay of puberty starts and ends completely without any medical intervention. adolescents hypogonadotropic hypogonadism is absent or does not continue its development. Differential diagnosis the conditions complicated due to lack standard recommendations for selection, conducting assessment stimulation tests.
 AIM: To assess information content find ways increase specificity tests triptorelin corionic gonadotropin in relation...