Modeling long-range DNA dependencies is crucial for understanding genome structure and function across a wide range of biological contexts. However, effectively capturing these extensive dependencies, which may span millions base pairs in tasks such as three-dimensional (3D) chromatin folding prediction, remains significant challenge. Furthermore, comprehensive benchmark suite evaluating that rely on notably absent. To address this gap, we introduce DNAL ong B ench , dataset encompassing...

<title>Abstract</title> This study presents a novel method for installing flexible appendages (hairs) on the surface of submersible to reduce its drag as it descends from seafloor. First, changes in drag, Reynolds stress, turbulent kinetic energy, and time-averaged streamlines flow field before after addition hair were analyzed using six-component sensor particle image velocimetry (PIV). The results indicate that, with optimal appendages, is reduced by 8.7% compared conventional (0...

This paper presents a path tracking algorithm based on fuzzy control pure model for autonomous navigation of 4WS agricultural machines. The aim this research is to implement unmanned machinery and solve the problem difficult determination forward-looking distances in algorithms. By using controller, converts heading deviation lateral one cycle into sum as first input controller vehicle travel speed second thus outputting actual distance. In order verify practicality, accuracy, precision...

Given a motion capture sequence with occlusions, how can we recover the missing values, respecting bone-length constraints? Recent past work uses Linear Dynamical Systems (LDS), which well, except for occasionally violating such constraints, and thus lead to unrealistic results. Our main contribution is principled approach preserving distances. Specifically (a) show formulate problem as constrained optimization problem, using two variations: hard soft constraints; (b) efficiently solve both...

Robustness testing is a crucial stage in the device driver development cycle. To accelerate robustness testing, effective fault scenarios need to be generated and injected without requiring much time human effort. In this paper, we present practical approach automatic runtime generation injection of for testing. We identify target functions that can fail from execution traces, generate on these using bounded trace-based iterative strategy, inject at test permutation-based mechanism. have...

The chemical investigation of the South China Sea soft coral Sinularia densa has resulted in isolation seven new terpenoids, including two meroterpenoids, namely sinudenoids F–G (1–2), and five cembranes, H–L (3–7). Their structures absolute configurations were elucidated based on extensive analyses spectroscopic data, single-crystal X-ray diffraction, comparison with literature quantum calculations. Among them, sinudenoid F (1) G (2) are rare meroterpenoids featuring a methyl benzoate core....

Sweet state is a basic physiological sensation of humans and other mammals which mediated by the broadly acting sweet taste receptor-the heterodimer Tas1r2 (taste receptor type 1 member 2) Tas1r3 3). Various sweeteners interact with either or then activate receptor. In this study, we cloned, expressed functionally characterized from species Old World monkeys, rhesus monkey. Paired human TAS1R3, it was shown that monkey could respond to natural sugars, amino acids their derivates....

Natural sweet protein monellin has a high sweetness and low calorie, suggesting its potential in food applications. However, due to heat acid resistance, the application of is limited. In this study, we show that thermostability can be improved with no decrease by means sequence, structure analysis, site-directed mutagenesis. We analyzed residues located α -helix as well an ionizable residue C41. Of mutants investigated, effects E23A C41A were most remarkable. The former displayed...

Abstract This paper proposed a novel disturbance observer‐based control state‐error port‐controlled Hamiltonian (DOBC‐SEPCH) strategy for optimization of energy consumption and enhancement tracking performance unmanned surface vehicle (USV) with unknown environmental disturbances via the PCH system techniques. Firstly, an observer is constructed to estimate disturbances. Then, energy‐based controller by using SEPCH method. In addition, provided that errors converged exponentially zero. The...

Seven new lobane diterpenoids, namely, lobocatalens A–G (1–7), were isolated from the Xisha soft coral Lobophytum catalai. Their structures, including their absolute configurations, elucidated via spectroscopic analysis, comparison with literature data, QM-MNR, and TDDFT-ECD calculations. Among them, lobocatalen A (1) is a diterpenoid an unusual ether linkage between C-14 C-18. In addition, compound 7 showed moderate anti-inflammatory activity in zebrafish models cytotoxic against K562 human...

This paper proposes a novel nonlinear control scheme based on energy-shaping (ES) principle and state error port-controlled Hamiltonian (PCH) systems for unmanned surface vehicles (USV) system. The PCH model of three degrees freedom USV kinetics system is established. By the ES principle, interconnection assignment damping injection method applied to speed heading closed-loop realize an overall stability mechanism. Simulation results show that validity algorithm can be satisfied with...

Analysis of power sharing between parallel grid-connected inverters is a popular topic in the microgrid research area. In this paper, droop control with secondary loop presented for an AC microgrid, to improve accuracy performance inverters. The calculates reference active and reactive input P-f/Q-V control. proposed method can be used microgrids which contain many micro sources loads variations both islanding operation modes. A simulation model three generators built test using...

This paper presents a methodology to design and control permanent magnet (PM) motor capable of 6-D force/torque actuation for real-time compensation external loads achieve minimum bearing reaction (MBR). Unlike conventional multiphase designs, the current inputs stator-electromagnets (EMs) can be flexibly configured enable force and/or torque in one motor; two common structures (radial axial types) are illustrated. Both forward inverse models presented terms coordinate-independent kernel...

In this paper, adaptive tracking control is applied to improve performances of an underactuated quadrotor helicopter with respect attitude and position control. Firstly, the dynamic model presented. Then a new trajectory algorithm designed by using sigma-pi neural network backstepping. The paper designs compensation law gives Lyapunov-type stability analysis. corresponding numerical simulations are performed MATLAB. Simulation results shown demonstrate effectiveness proposed strategy, which...