A5032399613- Particle Accelerators and Free-Electron Lasers
- Particle accelerators and beam dynamics
- Radiation Therapy and Dosimetry
- Particle Detector Development and Performance
- Nuclear Physics and Applications
- Laser-Plasma Interactions and Diagnostics
- Radiation Detection and Scintillator Technologies
- Magnetic confinement fusion research
- Radiation Effects in Electronics
- Gyrotron and Vacuum Electronics Research
- Advanced X-ray Imaging Techniques
- Advanced Radiotherapy Techniques
- Superconducting Materials and Applications
- Photocathodes and Microchannel Plates
- Nuclear reactor physics and engineering
- Plasma Diagnostics and Applications
- Crystallography and Radiation Phenomena
- Ion-surface interactions and analysis
- Diamond and Carbon-based Materials Research
- Particle physics theoretical and experimental studies
- Muon and positron interactions and applications
- Electron and X-Ray Spectroscopy Techniques
- Planetary Science and Exploration
- Atomic and Subatomic Physics Research
- CCD and CMOS Imaging Sensors
Institut Génétique Nantes Atlantique
2015-2024
Pontificia Universidad Católica de Valparaíso
2024
Centre National de la Recherche Scientifique
2011-2023
Laboratoire d’Annecy de Physique des Particules
2023
Montpellier GenomiX
2020-2023
IMT Atlantique
2019-2022
Laboratoire de Physique Subatomique et des Technologies Associées
2014-2022
Deleted Institution
2022
Cyclotron (Netherlands)
2011-2021
Nantes Université
2015-2019
During ultra-high dose rate (UHDR) external radiation therapy, healthy tissues appear to be spared while tumor control remains the same compared conventional rate. However, understanding of radiochemical and biological mechanisms involved are still discussed. This study shows how hydrogen peroxide (H2O2) production, one reactive oxygen species (ROS), could controlled by early heterogenous radiolysis processes in water during UHDR proton-beam irradiations. Pure was irradiated plateau region...
The ARRONAX cyclotron facility offers the possibility to deliver proton beams from low ultra-high dose rates (UHDR). As a good control of dosimetry is prerequisite UHDR experimentations, we evaluated in different conditions usability and rate dependency several radiochromic films commonly used for radiotherapy.We compared three types films: GAFchromic™ EBT3 EBT-XD (Ashland Inc., Wayne, NJ, USA), OrthoChromic OC-1 (OrthoChrome Hillsborough, after irradiations at various mean (0.25, 40, 1500,...
Radiobiological effectiveness of radiation in cancer treatment can be studied at different scales (molecular till organ scale) and time post irradiation. The production free radicals reactive oxygen species during water radiolysis is particularly relevant to understand the fundamental mechanisms playing a role observed biological outcomes. development validation Monte Carlo tools integrating simulation physical, physico-chemical chemical stages after very important maintain with experiments.
The cyclotron ARRONAX can deliver different types of particles (protons, deuterons, alpha-particles) in an energy range up to 68 MeV. One its six experimental halls is dedicated studying the interactions radiation with matter including living matter. A horizontal beamline for cell irradiation has been setup and characterized. radiobiological characterization was done terms V79 cells survival after MeV protons. results demonstrate that studies be successfully performed confirming high...
Proton therapy (PRT) is an irradiation technique that aims at limiting normal tissue damage while maintaining the tumor response. To study its specificities, ARRONAX cyclotron currently developing a preclinical structure compatible with biological experiments. A prerequisite to identify and control uncertainties on beamline, which can lead significant biases in observed results dose–response relationships, as for any facility. This paper summarizes quantifies impact of uncertainty proton...
In this paper, we report the progress and status of a full-featured so-called start-to-end simulation based on MERLIN library. The current model comprises acceleration in superconducting main linac, beam delivery system finally collision at IP. Realistic modelling beam-beam interaction is included by using code GUINEAPIG. Results ground motion trajectory control are presented.
In an effort to compare beam dynamics and create a "benchmark" for Dispersion Free Steering (DFS) comparison was made between different International Linear Collider (ILC) simulation programs while performing DFS. This study consisted of three parts. Firstly, simple betatron oscillation tracked through each code. Secondly, set component misalignments corrector settings generated from one program read into the others confirm similar emittance dilution. Thirdly, given same misalignments, DFS...
Compton scattering techniques for the measurement of transverse beam size particle beams at future linear colliders (FLC) are proposed. At several locations delivery system (BDS) FLC, spot sizes ranging from hundreds to a few micrometers have be measured. This is necessary verify optics, obtain emittance, and achieve highest possible luminosity. The large demagnification in BDS high power puts extreme conditions on any measuring device. With conventional their operational limit FLC...
The ARRONAX cyclotron is able to deliver alpha particles at 68 MeV. In the frame of radiological research, a new method studied infer in situ deposited dose: it based on online measurement bremsstrahlung (>1 keV) produced by interaction incident particle with medium. Experiments are made using bombarded poly(methyl methacrylate) (PMMA)-equivalent water targets order characterise this continuous X-ray spectrum. intensity spectrum allows for beam monitoring. A simulation code has been built,...
To advance the development of a radiobiological experimental set-up for alpha particle irradiations at Arronax cyclotron, experiments were performed to get dose response Gafchomic EBT2 films particles 48.3 MeV. A system has been developed using thin monitor copper foil and an X-ray spectrometer measure beam intensity calculate delivered dose. On other hand, authors have irradiated films, with 6-MV X rays, photons. The curve shows effect polymerisation saturation compared
The Laser-wire will be an essential diagnostic tool at the International Linear Collider. It uses a finely focussed laser beam to measure transverse profile of electron bunches by detecting Compton-scattered photons (or degraded electrons) downstream where intersects beam. Such system has been installed PETRA storage ring DESY, which piezo-driven mirror scan laser-light across Latest results experimental data taking are presented and compared detailed simulations using Geant4 based program BDSIM.