A5002110973- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Radiation Dose and Imaging
- Nuclear reactor physics and engineering
- Particle accelerators and beam dynamics
- Radiation Effects in Electronics
- Boron Compounds in Chemistry
- Advanced X-ray and CT Imaging
- Graphite, nuclear technology, radiation studies
- Atomic and Subatomic Physics Research
- Particle Detector Development and Performance
- Particle physics theoretical and experimental studies
- Engineering Applied Research
- Lung Cancer Diagnosis and Treatment
- Integrated Circuits and Semiconductor Failure Analysis
- Radiation Effects and Dosimetry
- Smart Agriculture and AI
- Hepatocellular Carcinoma Treatment and Prognosis
- Nanoparticle-Based Drug Delivery
- Anesthesia and Neurotoxicity Research
- Advances in Oncology and Radiotherapy
- Nuclear physics research studies
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2012-2023
Unidades Centrales Científico-Técnicas
2009-2022
Universidad de Sevilla
2003-2015
Universidad Complutense de Madrid
2013
Hospital Universitario Virgen Macarena
2003-2012
Pontificia Universidad Católica de Chile
2012
Hospital Universitario Puerta de Hierro Majadahonda
2012
Instituto de Química Médica
2011
Intensity modulated radiation therapy (IMRT) has evolved toward the use of many small fields, or “beamlets,” to increase resolution intensity map. The size smaller beamlets can be typically about 1–5 cm 2 . Therefore ionization chambers (IC) with sensitive volumes ⩽0.1 3 are generally used for dose verification IMRT treatment. dosimetry these narrow photon beams pertains so‐called nonreference conditions beam calibration. ion such remains questionable due lack electron equilibrium in most...
The use of Monte Carlo has proved to be an essential tool in nuclear medicine, assist the design new medical devices, development image reconstruction algorithms and correction techniques PET SPECT, for precise determination dose radiotherapy, etc. Among several general-purpose codes, Geant4 is widely used its modern technology, flexibility wide range applications. Nevertheless medicine requires often a long learning-curve that implies good knowledge C++ codes itself write code needed obtain...
Absolute dosimetry with ionization chambers of the narrow photon fields used in stereotactic techniques and IMRT beamlets is constrained by lack electron equilibrium radiation field. It questionable that stopping-power ratio protocols, obtained for broad beams quasi-electron conditions, can be while keeping uncertainty at same level as accelerator calibrations. Monte Carlo simulations have been performed two 6 MV clinical accelerators (Elekta SL-18 Siemens Mevatron Primus), equipped...
Neutron peripheral contamination in patients undergoing high-energy photon radiotherapy is considered as a risk factor for secondary cancer induction. Organ-specific neutron-equivalent dose estimation therefore essential reasonable assessment of these associated risks. This work aimed to develop method estimate doses multiple organs patients. The involved the convolution, at 16 reference points an anthropomorphic phantom, normalized Monte Carlo neutron fluence energy spectra with kerma and...
This work aims to generate a simple analytical model that allows estimation of peripheral photon equivalent dose organs individual patients, valid for any isocentric technique. Photon radiation scattered in the LINAC head has been simulated as virtual source emitting isotropically so that, before reaching point inside patient, it decreases with square law and attenuation due air tissue. Leakage constant background along patient. Firstly, dose-to-points basic was proposed parameterized by...
The wide range of physics models available in GEANT4, as well its outstanding geometry and visualization tools, has made it gain widespread use several fields physics, like high energy, medical, space, etc. Nevertheless the GEANT4 often requires a long learning-curve, which implies good knowledge C++ code itself. GAMOS facilitates by avoiding need to C++, providing instead set user commands. One novelties with respect similar simulation codes lies flexibility, makes appropriate for many...
Purpose: Peripheral dose in radiotherapy treatments represents a potential source of secondary neoplasic processes. As the last few years, there has been fast‐growing concern on neutron collateral effects, this work focuses component. A previous established methodology to estimate peripheral equivalent doses relied passive (TLD, CR39) detectors exposed in‐phantom, parallel an active [static random access memory ( SRAMnd )] thermal detector ex‐phantom. newly miniaturized, quick, and reliable...
Proton therapy allows the treatment of specific areas and avoids surrounding tissues. However, this technique has uncertainties in terms distal dose fall-off. A promising approach to studying proton range is use nanoparticles as proton-activatable agents that produce detectable signals. For this, we developed an iron oxide nanoparticle doped with Zn (IONP@Zn-cit) a hydrodynamic size 10 nm stability serum. Cytotoxicity, defined half surveillance, was 100 μg Zn/mL U251 cell line. The effect on...
A simple and straightforward method is presented for the direct proton beam activation of 18 O‐enriched titanium dioxide nanoparticles (TiO 2 NPs) via O(p,n) F nuclear reaction in order to assess biological fate NPs using positron emission tomography (PET). The radiolabeling does not alter their morphological properties as demonstrated by transmission electron microscopy dynamic light scattering measurements. simultaneous formation other radioisotopes atom, i.e., 48 V, 47 44g Sc, has been...
Intensity modulated radiotherapy (IMRT) has become a treatment of choice in many oncological institutions. Small fields or beamlets with sizes 1 to 5 cm2 are now routinely used IMRT delivery. Therefore small ionization chambers (IC) sensitive volumes 0.1 cm3 generally for dose verification an treatment. The measurement conditions during may be quite different from reference normally encountered clinical beam calibration, so dosimetry these narrow photon beams pertains the so-called...
The aim of this work is to present a reproducible methodology for the evaluation total equivalent doses in organs during proton therapy facilities. based on measuring dose representative locations inside an anthropomorphic phantom where photon and neutron dosimeters were inserted. Monte Carlo simulation was needed obtaining energy distribution phantom. implemented head irradiation case passive beam iThemba Labs (South Africa). Thermoluminescent dosimeter (TLD)-600 TLD-700 pairs used as GEANT...
Total skin electron therapy (TSET) is a complex technique which requires non-standard measurements and dosimetric procedures. This paper investigates an essential first step towards TSET Monte Carlo (MC) verification. The 6 MeV 40 × cm2 beam at source to surface distance (SSD) of 100 cm as well its horizontal projection behind polymethylmethacrylate (PMMA) screen SSD = 380 were evaluated. EGS4 OMEGA-BEAM code package running on Linux home made 47 PCs cluster was used for the MC simulations....
Recent developments in radiation detection technology have demonstrated the feasibility of simultaneous magnetic resonance imaging (MRI) and time-of-flight positron emission tomography (TOF-PET). In this paper we report on a compact detector module design for TOF-PET compatible with MR based FlexToT front-end application specific integrated circuit (ASIC), fast, low-power readout silicon photomultiplier arrays. The comprises scintillators, photosensors, ASICs, field-programmable gate arrays,...
We have verified the GAMOS/Geant4 simulation model of a 6 MV VARIAN Clinac 2100 C/D linear accelerator by procedure adjusting initial beam parameters to fit percentage depth dose and cross-profile experimental data at different depths in water phantom. Thanks use wide range field sizes, from 2 × cm2 40 cm2, small phantom voxel size high statistics, fine precision determination has been achieved. This allowed us make thorough study physics models that Geant4 offers. The three electromagnetic...