A5014440116- COVID-19 Impact on Reproduction
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Maternal and fetal healthcare
Hospital General de México
2021
Clinical manifestations of coronavirus disease 2019 (COVID-19) in pregnant women are diverse, and little is known the impact on placental physiology. Severe acute respiratory syndrome (SARS-CoV-2) has been detected human placenta, its binding receptor ACE2 present a variety cells, including endothelium. Here, we analyze COVID-19 endothelium, studying by immunofluorescence expression von Willebrand factor (vWf), claudin-5, vascular endothelial (VE) cadherin decidua chorionic villi placentas...
In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in placental villi and contribute to invasion, migration, angiogenesis. At same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding ANG-II its receptor (AT-1R) response hypoxia. As RAS plays an essential role pathogenesis COVID-19, we hypothesized that angiogenic marker (ANG-II ACE-2) may be related adverse outcomes pregnant women with COVID-19; Methods: Prospective cohort...
In addition to the lungs, placenta and endothelium can be affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Soluble fms-like tyrosine kinase-1 (sFlt-1) placental growth factor (PlGF) are markers of endothelial dysfunction could potentially serve as predictors disease 2019 (COVID-19). We aimed investigate association serum concentrations sFlt-1 PlGF with severity COVID-19 in pregnancy.This was a prospective cohort study carried out tertiary care hospital Mexico City,...