A5055763747- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- CAR-T cell therapy research
University of Chicago
2020-2025
During infections, CD4 + Foxp3 regulatory T (Treg) cells must control autoreactive conventional (Tconv) cell responses against self-peptide antigens while permitting those pathogen-derived “nonself” peptides. We defined the basis of this selectivity using mice in which Treg reactive to a single prostate-specific were selectively depleted. found that self-peptide-specific dispensable for Tconv matched specificity at homeostasis. However, they required such and prevent autoimmunity toward...
For the large array of self-peptide/MHC class II (pMHC-II) complexes displayed in body, it is unclear whether CD4+ T cell tolerance must be imparted for each individual complex or pMHC-II–nonspecific bystander mechanisms are sufficient to confer by acting broadly on cells reactive multiple self-pMHC-II ligands. Here, via reconstitution cell–deficient mice, we demonstrate that altered selection a single prostate-specific ligand renders recipient mice susceptible infiltration. Mechanistically,...
Abstract In both humans and mice, self-reactive CD4+ T cells are implicated in a range of autoinflammatory processes. To promote disease, such must evade clonal deletion the thymus, as well intrinsic extrinsic regulation mechanisms periphery, including anergy regulatory cell-mediated suppression. However, impact cell receptor (TCR) - peptide/MHC class II (pMHCII) binding properties on autoimmune potential self-specific their susceptibility to immune remains incompletely defined. Much...