A5015104797- Axon Guidance and Neuronal Signaling
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Optimism, Hope, and Well-being
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Food Security and Health in Diverse Populations
- Liver Disease Diagnosis and Treatment
- Apelin-related biomedical research
- Renal Transplantation Outcomes and Treatments
- Public Health Policies and Education
- Health disparities and outcomes
- Organ Transplantation Techniques and Outcomes
- Neurogenesis and neuroplasticity mechanisms
- Heart Failure Treatment and Management
- Liver Disease and Transplantation
- Zebrafish Biomedical Research Applications
- Erythrocyte Function and Pathophysiology
- Transplantation: Methods and Outcomes
Fred Hutch Cancer Center
2022-2025
University of Chicago
2020-2023
International Society for Heart and Lung Transplantation
2023
To derive and validate a new ecological measure of the social determinants health (SDoH), calculable at zip code or county level.The most recent releases secondary, publicly available data were collected from national U.S. agencies as well state city public departments.The Social Vulnerability Metric (SVM) was constructed zip-code level measures (2018) survey using multidimensional Item Response Theory validated outcomes including all-cause mortality (2016), COVID-19 vaccination (2021),...
<h3>Importance</h3> There has been large geographic inequity in vaccination coverage across Chicago, Illinois, with higher rates zip codes residents who predominantly have high incomes and are White. <h3>Objective</h3> To determine the association between inequitable code–level COVID-19 mortality Chicago. <h3>Design, Setting, Participants</h3> This retrospective cohort study used Chicago Department of Public Health data Cook County Medical Examiner from March 1, 2020, through November 6,...
In the United States, over half of pediatric candidates receive exceptions and status upgrades that increase their allocation model end-stage liver disease/pediatric disease (MELD/PELD) score above laboratory MELD/PELD score. We determined whether these "nonstandardized" accurately depict true pretransplant mortality risk.Using data from Scientific Registry Transplant Recipients, we identified (<18 y age) with chronic failure added to waitlist between June 2016 September 2021 estimated...
SUMMARY Somatic stem cell pools are comprised of diverse, highly specialized subsets whose individual contribution is critical for the overall regenerative function. In bone marrow, myeloid-biased HSC (myHSC) indispensable replenishment myeloid cells and platelets during inflammatory response but at same time, become irreversibly damaged inflammation aging. Here, we identify an extrinsic factor, Semaphorin 4A (Sema4A), which non cell-autonomously confers myHSC resilience to stress. We show...
SUMMARY Tissue stem cells are hierarchically organized. Those that most primitive serve as key drivers of regenerative response but the signals selectively preserve their functional integrity largely unknown. Here, we identify a secreted factor, Semaphorin 4A (Sema4A), specific regulator myeloid-biased hematopoietic (myHSC), which positioned at top HSC hierarchy. Lack Sema4A leads to exaggerated myHSC (but not downstream “balanced” HSC) proliferation after acute inflammatory stress,...
ABSTRACT During Chicago’s initial COVID-19 vaccine rollout, the city disproportionately allocated vaccines to zip codes with high incomes and predominantly White populations. However, impact of this inequitable distribution on outcomes is unknown. This observational study determined association between zip-code level vaccination rate mortality in residents 52 Chicago codes. After controlling for age recovery from infection, a 10% higher by March 28, 2021, was associated 39% lower relative...
Tissue stem cells are hierarchically organized. Those that most primitive serve as key drivers of regenerative response but the signals selectively preserve their functional integrity largely unknown. Here, we identify a secreted factor, Semaphorin 4A (Sema4A), specific regulator myeloid-biased hematopoietic (myHSC), which positioned at top HSC hierarchy. Lack Sema4A leads to exaggerated myHSC (but not downstream “balanced” HSC) proliferation after acute inflammatory stress, indicating...
Abstract In both humans and mice, self-reactive CD4+ T cells are implicated in a range of autoinflammatory processes. To promote disease, such must evade clonal deletion the thymus, as well intrinsic extrinsic regulation mechanisms periphery, including anergy regulatory cell-mediated suppression. However, impact cell receptor (TCR) - peptide/MHC class II (pMHCII) binding properties on autoimmune potential self-specific their susceptibility to immune remains incompletely defined. Much...