A5010601661- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Traumatic Brain Injury and Neurovascular Disturbances
- Restraint-Related Deaths
- Peptidase Inhibition and Analysis
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and Diving-Related Complications
- Congenital Heart Disease Studies
- Phosphodiesterase function and regulation
- Facial Trauma and Fracture Management
- Gun Ownership and Violence Research
- Digital Imaging in Medicine
- Medical Device Sterilization and Disinfection
- Ubiquitin and proteasome pathways
- Dialysis and Renal Disease Management
- Shoulder and Clavicle Injuries
- Renal and Vascular Pathologies
- Acute Ischemic Stroke Management
- Click Chemistry and Applications
- Bone fractures and treatments
- Central Venous Catheters and Hemodialysis
- Hip and Femur Fractures
- Heart Failure Treatment and Management
- Autopsy Techniques and Outcomes
- Advanced Breast Cancer Therapies
New York University
2011-2025
Emory University
2022
NewYork–Presbyterian Hospital
2020-2021
Columbia University Irving Medical Center
2020-2021
Columbia University
2020
California State University, Channel Islands
2020
Washington State University
2020
University of Pennsylvania
2018
Office of Chief Medical Examiner
2017
Merlin Park University Hospital
2005
Typical carotid webs are nonatherosclerotic shelf-like projections of fibromyxoid tissue extending from the posterior wall proximal internal artery (ICA). Carotid may precipitate acute embolic stroke, especially in younger patients. We describe our experience with pathology-proven atypical appearance, or (ACWs), a subset exhibiting abnormal location, morphology, association atherosclerotic changes. Our electronic medical record database was queried for all imaging impressions containing...
The National Association of Medical Examiners commissioned an ad hoc committee to provide recommendations for the investigation, examination, and reporting deaths in custody. Deaths custody, whether occuring jail/prison or during altercation with law enforcement, is a complex issue requires forensic pathologist be knowledgable deliberative about his/her diagnosis. This paper provides as it relates 1) categorization 2) critical information required 3) enhanced autopsy procedures, 4) guidance...
ABSTRACT Despite the anticancer activity of pan-histone deacetylase (HDAC) inhibitors, their clinical use has been limited due to toxicity. However, development more specific inhibitors that selectively inhibit individual HDACs is emerging as a novel and well-tolerated alternative. Here, we present results first trial evaluating ricolinostat (the leading HDAC6 inhibitor) in breast cancer (BC) patients. We have developed computational network-based algorithm evaluate protein, based on...
Despite the anticancer activity of pan-histone deacetylase (HDAC) inhibitors, their clinical use has been limited due to toxicity. However, development more specific inhibitors that selectively inhibit individual HDACs is emerging as a novel and well-tolerated alternative. Here, we present results first trial evaluating ricolinostat (the leading HDAC6 inhibitor) in breast cancer (BC) patients.We have developed computational network-based algorithm evaluate protein, based on enrichment its...
A 29-year-old man sustained a near-complete laceration to the left pectoralis major muscle belly. The and epimysium were repaired using Kragh technique-a combination of running interlocked Mason-Allen stitches. At 6-year follow-up, patient had an excellent outcome as measured by clinical scores (Short Form Survey-36, Disabilities Arm, Shoulder, Hand, American Shoulder Elbow Surgeons Score), bench press, cosmesis, magnetic resonance imaging.Acute traumatic open belly tears may be successfully...
Abstract Background:HDAC6, a cytoplasmic histone deacetylase, impacts cell viability by influencing protein metabolism, microtubule dynamics, and chaperone function. ACY-1215 is an orally active, selective HDAC6 inhibitor. Preclinical studies have demonstrated to synergistic activity with taxanes. We developed algorithm (HDAC6 score) based on mRNA expression profiling evaluate the of individual tumor samples. Methods: In this open-label phase Ib trial, patients (pts) received PO daily for 21...
Abstract Despite the anticancer activity of pan-histone deacetylase (HDAC) inhibitors, their clinical use has been limited due to toxicity. However, development more specific inhibitors that selectively inhibit individual HDACs is emerging as a novel and well-tolerated alternative. Here, we present results first trial evaluating ricolinostat (the leading HDAC6 inhibitor) in breast cancer (BC) patients. We have developed computational network-based algorithm evaluate protein, based on...