A5004818579- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Cancer Genomics and Diagnostics
- Tumors and Oncological Cases
- Neuroblastoma Research and Treatments
- Renal and Vascular Pathologies
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Nerve Disorders
- Congenital Heart Disease Studies
- Cellular transport and secretion
- Hereditary Neurological Disorders
- Glioma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
Hinge Health
2025
New York University
2025
NYU Langone Health
2023
Tunis El Manar University
2020-2021
Johns Hopkins Medicine
2020-2021
Johns Hopkins University
2020-2021
Abstract Background Plexiform neurofibromas can transform into atypical (ANF) and then further progress to aggressive malignant peripheral nerve sheath tumors (MPNST). ANF have been described harbor distinct histological features frequent loss of CDKN2A/B. However, evaluation may be rater-dependent, detailed knowledge about the molecular mechanisms transformation is scarce. In general, accompanied by significant epigenetic changes, global DNA methylation profiling able differentiate relevant...
Typical carotid webs are nonatherosclerotic shelf-like projections of fibromyxoid tissue extending from the posterior wall proximal internal artery (ICA). Carotid may precipitate acute embolic stroke, especially in younger patients. We describe our experience with pathology-proven atypical appearance, or (ACWs), a subset exhibiting abnormal location, morphology, association atherosclerotic changes. Our electronic medical record database was queried for all imaging impressions containing...
Abstract Background Pituitary neuroendocrine tumors (PitNETs) are the most common intracranial tumors. PitNETs can be challenging to classify, and current recommendations include a large immunohistochemical panel differentiate among 14 WHO-recognized categories. Methods In this study, we analyzed clinical, DNA methylation data of 118 develop clinico-molecular approach classifying identify epigenetic classes. Results CNS classifier has an excellent performance in recognizing distinguishing...
Abstract Localized hypertrophic neuropathy is a rare Schwann cell proliferation that usually affects single nerves from the extremities, and it of unclear etiology in its pure form. RASopathies are defined group genetic diseases with overlapping clinical features, secondary to germline mutations genes encoding either components or regulators RAS/MAPK pathway. Herein, we report an 11-year-old boy presenting café au lait spots right leg length discrepancy. A fascicular nerve biopsy tibial...
Abstract Cancer of unknown primary (CUP) constitutes between 2% and 5% human malignancies is among the most common causes cancer death in United States. Brain metastases are often first clinical presentation CUP; despite extensive pathological imaging studies, 20%-45% CUP never assigned a site. DNA methylation array profiling reliable method for tumor classification but tumor-type-specific classifier development requires many reference samples. This difficult to accomplish as cases specific...