Carbocation-initiated cascade [1,5]-hydride transfer/cyclization and dimerization reactions were developed to synthesize dihydrodibenzo[b,e]azepine octahydrodipyrroloquinoline derivatives in high yields. These redox-neutral C(sp3)-H functionalization-involving feature transition-metal-free, atom- step-economy, environmental friendliness with water as the sole byproduct.

Water enabled a highly atom- and step-economical, redox-neutral 4-step cascade process, including S_NAr/Knoevenagel condensation/[1,5]-hydride transfer cyclization, to construct pharmaceutically important tetrahydroquinoline spiro compounds efficiently.

Described herein is an unprecedented N-alkylation-initiated redox-neutral [5 + 2] annulation of 3-alkylindoles with o-aminobenzaldehydes via a cascade N-alkylation/dehydration/[1,5]-hydride transfer/Friedel-Crafts alkylation sequence. A series indole-1,2-fused 1,4-benzodiazepines are facilely constructed in moderate to good yields one step. This protocol features excellent regioselectivity, metal-free conditions, high step economy, and wide substrate scope.

The organocatalytic alkylation of 2-methyl-N-heteroaromatics with alcohols has been achieved via SN1-type C(sp3)–H functionalization, providing a green and efficient synthesis indole ferrocene-functionalized N-heteroaromatics in high yields.

Abstract In the process of electrochemical ammonia synthesis using an aqueous solution as electrolyte, most protons will preferentially compete for electrons hydrogen generation. Herein, carbon cloth loaded with Nano‐Fe was used cathode, and a K 3 PO 4 electrolyte. The reduction N 2 to NH investigated. It found that electrolyte had obvious promotion effect on efficiency compared other electrolytes. confirmed phosphorus potassium synergistic efficiency. + can effectively prevent H from...

Hexafluoroisopropanol has been demonstrated as the versatile promoter for redox-neutral α-C(sp3)–H functionalization of cyclic amines via cascade [1,5]-hydride transfer/cyclization strategy. A wide range are functionalized into bioactive tetrahydroquinolines, quinazolines, benzoxazines, and benzotriazepines in moderate to excellent yields. This protocol features additive-free conditions, operational simplicity, substrate scope.

This article reports an efficient synthesis of triarylmethanes and tetraarylmethanes from chlorohydrocarbons with miscellaneous nucleophiles in fluorinated alcohols, featuring metal-free, wide substrate scope, excellent functional group tolerance, mild reaction conditions.

The oxindole-embedded ortho-quinone methides were employed as reactive intermediates in formal [4 + 2] annulation with 1,3-dicarbonyls, providing an efficient access to spiro[chromen-4,3′-oxindole] scaffolds via a cascade conjugate addition/ketalization/dehydration process. This protocol featured metal-free conditions, wide substrate scope, and excellent yields.

Abstract 2,5‐Dialkylfurans were facilely converted to pharmaceutically significant spiro[chroman‐4,3′‐oxindole] scaffolds via an organocatalytic dearomative [4+2] cycloaddition with oxindole‐embedded ortho ‐quinone methides. This method featured mild reaction conditions, simple operation, good yields, and excellent diastereoselectivities. magnified image

Abstract Enzymes as catalysts have attracted significant attention due to their excellent specificity and incomparable efficiency, but practical application is limited because these are difficult separate recover. A magnetically recoverable biocatalyst has been effectively prepared through the immobilization of a nitroreductase (oxygen-insensitive, purified from Enterobacter cloacae ) onto Fe 3 O 4 nanoparticles. The magnetic nanoparticles (MNPs) were synthesized by coprecipitation method in...

An organocatalytic C(sp3)–H functionalization of 5-methyl-2,3-dihydrofuran derivatives with trifluoropyruvates was achieved via a sequential exo-tautomerization/carbonyl-ene process, providing the biologically important CF3-substituted 2,3-dihydrofurans in high yields. This method featured mild metal-free conditions, good chemoselectivity, and easy scalability.

The weighted intrinsic viscosities of polysaccharide mixtures in dilute aqueous solutions have been studied. purpose this investigation is to demonstrate that average would scale with the weight fraction individual components for 0.5N NaOH(aq). polysaccharides examined study were composed polymers differing their molecular weights, degree branching, and bond linkages. Excellent agreement between theory experiment was observed three different mixed polymer systems examined. This observation...

Using a prepared ionic liquid with high N 2 solubility as the electrolyte and isopropanol proton source, we achieved one-step electrocatalytic synthesis of ammonia acetone considerable yield faradaic efficiency.

Abstract An environmentally benign cascade redox process was developed for the efficient construction of pharmaceutically significant spirocyclic tetrahydroquinolines via sequential SNAr/Knoevenagel condensation/[1,5]-hydride transfer/cyclization. This green transformation has features being catalyst-free, additive-free, operationally simple, and high step- atom-economy.