A5088928685- Neonatal Health and Biochemistry
- Heme Oxygenase-1 and Carbon Monoxide
- Liver Disease Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Cancer, Hypoxia, and Metabolism
- Celiac Disease Research and Management
- Gastrointestinal disorders and treatments
- Drug Transport and Resistance Mechanisms
- Microscopic Colitis
Centro di Riferimento Oncologico
2024
University of Trieste
2019-2022
A new, bifunctional recombinant protein was expressed as the fusion product of human elastin-like polypeptide (HELP) and bilirubin-binding UnaG. The engineered displays both HELP-specific property forming a functional hydrogel matrix UnaG-specific capacity emitting green fluorescence upon ligand binding. new has been proven to be effective at detecting bilirubin in complex environments with high background noise. cell culture model stress response, consisting released medium, set up assess...
One of the organ-specific functions liver is excretion bilirubin into bile. Membrane transport from blood to not only an orphan function, because there no link protein/gene units that perform this but also a poorly characterised function. The aim study was investigate pharmacology uptake in female Wistar rat improve basic knowledge neglected area physiology. We treated isolated perfused livers rats with repeated single-pass, albumin-free boli. monitored both and glucuronide perfusion...
Intestinal anti-endomysium antibodies are a specific marker of celiac disease. The diagnostic accuracy this seems high in pediatric patients and has not yet been investigated adults, so the aim prospective multicentric study was to evaluate specificity sensitivity childhood adulthood. Pediatric adult undergoing intestinal endoscopy for any condition were enrolled. Serological disease markers HLA type evaluated all patients. biopsies analyzed standard histology with biopsy culture assay. In...
Abstract We present a protocol for the study of bilirubin uptake in isolated and perfused rat liver. The liver is with an albumin-free saline buffered solution supplemented glucose, pyruvate lactate, absence oxygen, at physiologically low flow rate. Fractions venous effluent are collected analyzed bilirubin, glucuronide biomarkers integrity. preparation viable intact 1 h after isolation from general circulation, constant levels both (< 2 nM) effluent. Up to 12 boli 10 nmol can be...
Abstract Background & Aims: One of the organ-specific functions liver is excretion bilirubin into bile. Membrane transport from blood to not only an orphan function, as there no link protein/gene entities that carry it out, but also a poorly characterised function. The aim this study was investigate pharmacology uptake in female Wistar rat improve basic knowledge neglected area physiology. Methods: We treated isolated, perfused livers with repeated single-pass, albumin-free boli....